In silico and saturation transfer difference NMR approaches to unravel the binding mode of an andrographolide derivative to K-Ras oncoprotein

Background: Andrographolide and its benzylidene derivatives, SRJ09 and SRJ23, potentially bind oncogenic K-Ras to exert anticancer activity. Their molecular interactions with K-Ras oncoproteins that lead to effective biological activity are of major interest. Methods & results: In silico docking...

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Bibliographic Details
Main Authors: Shun, Ying Quah, Tan, Michelle Siying, Kok, Lian Ho, Abd Manan, Nizar, Gorfe, Alemayehu A., Deb, Pran Kishore, Sagineedu, Sreenivasa Rao, Stanslas, Johnson
Format: Article
Published: Future Science 2020
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