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Diagnosis of neonatal meningitis: is it time to use polymerase chain reaction?

Group B Streptococcus (GBS) is a predominant causative pathogen of neonatal meningitis that is associated with a high rate of mortality and morbidity. The establishment of antenatal screening and intrapartum chemoprophylaxis has led to a significant reduction in the incidence rate of invasive GBS di...

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Main Authors: Zainudin, Zurina, Hoo, Nicole Phing Jie, Amin Nordin, Syafinaz, Sither Joseph Vesudian, Narcisse Mary, Nunis, Melissa Anne
Format: Article
Jezik:English
Izdano: Malaysian Medical Association 2021
Online dostop:http://psasir.upm.edu.my/id/eprint/96713/1/ABSTRACT.pdf
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id oai:psasir.upm.edu.my:96713
record_format eprints
spelling oai:psasir.upm.edu.my:96713 http://psasir.upm.edu.my/id/eprint/96713/ Diagnosis of neonatal meningitis: is it time to use polymerase chain reaction? Zainudin, Zurina Hoo, Nicole Phing Jie Amin Nordin, Syafinaz Sither Joseph Vesudian, Narcisse Mary Nunis, Melissa Anne Group B Streptococcus (GBS) is a predominant causative pathogen of neonatal meningitis that is associated with a high rate of mortality and morbidity. The establishment of antenatal screening and intrapartum chemoprophylaxis has led to a significant reduction in the incidence rate of invasive GBS disease in developed countries. However, these strategies are not routinely practiced in most developing countries. To ensure good recovery of infants affected with GBS, a prompt diagnostic strategy and appropriate therapy are essential. We highlight here the case of a preterm male infant diagnosed with early-onset of GBS meningitis diagnosed by using polymerase chain reaction (PCR) method on the cerebrospinal fluid (CSF) of the infant. Initially the pathogen was not isolated in both blood and CSF cultures as sampling was performed after the administration of antibiotics. Hence, PCR was a crucial diagnostic test in facilitating the detection of the pathogen in CSF. We believe that PCR is a potentially fast and precise diagnostic method for infection in a newborn. Malaysian Medical Association 2021 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/96713/1/ABSTRACT.pdf Zainudin, Zurina and Hoo, Nicole Phing Jie and Amin Nordin, Syafinaz and Sither Joseph Vesudian, Narcisse Mary and Nunis, Melissa Anne (2021) Diagnosis of neonatal meningitis: is it time to use polymerase chain reaction? Medical Journal of Malaysia, 76 (1). 101 - 102. ISSN 0300-5283 http://www.e-mjm.org/2021/v76n1
institution UPM IR
collection UPM IR
language English
description Group B Streptococcus (GBS) is a predominant causative pathogen of neonatal meningitis that is associated with a high rate of mortality and morbidity. The establishment of antenatal screening and intrapartum chemoprophylaxis has led to a significant reduction in the incidence rate of invasive GBS disease in developed countries. However, these strategies are not routinely practiced in most developing countries. To ensure good recovery of infants affected with GBS, a prompt diagnostic strategy and appropriate therapy are essential. We highlight here the case of a preterm male infant diagnosed with early-onset of GBS meningitis diagnosed by using polymerase chain reaction (PCR) method on the cerebrospinal fluid (CSF) of the infant. Initially the pathogen was not isolated in both blood and CSF cultures as sampling was performed after the administration of antibiotics. Hence, PCR was a crucial diagnostic test in facilitating the detection of the pathogen in CSF. We believe that PCR is a potentially fast and precise diagnostic method for infection in a newborn.
format Article
author Zainudin, Zurina
Hoo, Nicole Phing Jie
Amin Nordin, Syafinaz
Sither Joseph Vesudian, Narcisse Mary
Nunis, Melissa Anne
spellingShingle Zainudin, Zurina
Hoo, Nicole Phing Jie
Amin Nordin, Syafinaz
Sither Joseph Vesudian, Narcisse Mary
Nunis, Melissa Anne
Diagnosis of neonatal meningitis: is it time to use polymerase chain reaction?
author_facet Zainudin, Zurina
Hoo, Nicole Phing Jie
Amin Nordin, Syafinaz
Sither Joseph Vesudian, Narcisse Mary
Nunis, Melissa Anne
author_sort Zainudin, Zurina
title Diagnosis of neonatal meningitis: is it time to use polymerase chain reaction?
title_short Diagnosis of neonatal meningitis: is it time to use polymerase chain reaction?
title_full Diagnosis of neonatal meningitis: is it time to use polymerase chain reaction?
title_fullStr Diagnosis of neonatal meningitis: is it time to use polymerase chain reaction?
title_full_unstemmed Diagnosis of neonatal meningitis: is it time to use polymerase chain reaction?
title_sort diagnosis of neonatal meningitis: is it time to use polymerase chain reaction?
publisher Malaysian Medical Association
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/96713/1/ABSTRACT.pdf
_version_ 1819300873386328064
score 13.4562235

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