C-erbB-2 onco-protein expression in breast cancer : relationship to tumour characteristics and survival of patients /
Purpose The objective ofthis study was to evaluate the relationship between c-erbB-2 onco¬protein overexpression with various tumour characteristics and survival rate in breast cancer patients. Patients and Methods This was a retrospective cohort study which utili sed sections of formalin-fixed, par...
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| Định dạng: | Luận văn Sách |
| Ngôn ngữ: | English |
| Được phát hành: |
2007.
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| Những chủ đề: | |
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| Tóm tắt: | Purpose The objective ofthis study was to evaluate the relationship between c-erbB-2 onco¬protein overexpression with various tumour characteristics and survival rate in breast cancer patients. Patients and Methods This was a retrospective cohort study which utili sed sections of formalin-fixed, paraffin¬embedded tissue samples from primary invasive breast carcinomas (ductal and nonductal) operated between 1996-2000. Patient's clinical data and follow up information were traced using hospital, pathology laboratory, and oncology or radiotherapy records. C¬erbB-2 oncoprotein overexpression was determined by immunohistochemistry (IHC) and tumors showing 2+ positivity were verified by Fluorescence In Situ Hybridization (FISH). Results One hundred and seventy two patients were eligible for the study with a short-term follow-up (median, 5.1 years). C-erbB-2 oncoprotein overexpression correlated with lymph node positivity, oestrogen receptor (ER) and progesterone receptor (PR) negativity. Univariate analyses showed shorter disease free survival (DFS) and overall survival (OS) in patients with c-erbB-2 oncoprotein overexpression, Malay ethnicity, higher tumour grade, lymph node positivity, ER and PR negativity In a subgroup of patients with c-erbB-2 oncoprotein overexpression, a shorter os was observed in those with lymph node positivity, ER and PR negativity. In multivariate prognostic analysis, lymph node status, ER status and tumour grading were the strongest independent prognostic factors for both os and DFS. However, c-erbB-2 status was not a significantly independent prognostic factor, even in subsets with lymph node positive or negative group. Conclusion C-erbB-2 oncoprotein overexpression correlated well with lymph node status, ER and PRo Shorter os and DFS were significantly observed in patients with c-erbB-2 oncoprotein overexpression. Lymph node status, ER status and tumour grading were the only three independent prognostic factors for os and DFS in this study. Although c¬erbB-2 expression was obviously important from a biological standpoint, in this study multivariate analysis showed that c-erbB-2 was not recognized as an independent prognostic indicator in breast carcinoma in the local population. Keywords C-erbB-2 oncoprotein, breast carcinoma, prognostic factor. |
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| Mô tả vật lý: | 49 leaves : ill. ; 30cm. |