The effect of pre-emptive gabapentin, tramadol, and midazolam as pre-anesthetic medications on propofol induction dosage and recovery time in cats /
The appropriate usage of sedation to reduce the requirement for general anaesthesia is crucial in avoiding detrimental complications, such as apnea, prolonged recovery, arrhythmia, bradycardia, and acute kidney failure. However, the effects of common sedative drugs used in Malaysia have not been ext...
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| Format: | Thesis Book |
| Language: | English |
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| Summary: | The appropriate usage of sedation to reduce the requirement for general anaesthesia is crucial in avoiding detrimental complications, such as apnea, prolonged recovery, arrhythmia, bradycardia, and acute kidney failure. However, the effects of common sedative drugs used in Malaysia have not been extensively studied. Gabapentin and tramadol are commonly used drugs in private clinic settings, providing effective pain management and reducing the general anaesthesia requirement for healthy cats undergoing ovariohysterectomy. Despite their widespread use, limited information exists on the pre-emptive effects of these medications on propofol dosage requirements for induction and recovery time in cats. Therefore, this study aimed to compare the effects of pre-emptive administration of gabapentin, tramadol, and midazolam as pre-anesthetic medications on propofol induction dosage and recovery time in cats. A total of six cats requiring general anaesthesia for surgery were recruited as study subjects. Each patient was
assigned to either the negative control group (normal saline only for placebo) (n = 3) or the gabapentin, tramadol, and midazolam group (n = 3). The total propofol dosage needed for successful induction and the time from propofol cessation to the patient’s first swallowing reflex were measured. The results revealed that the average propofol dosage (3.77 ± 0.12 mg/kg) requirement for patients sedated with gabapentin, tramadol, and midazolam (GTM) was significantly lower (p = 0.001) than that of the negative control group (10.43 ± 0.81 mg/kg). The groups administered with GTM (11.67 ± 1.2 min) have significantly longer recovery time (p = 0.016) when compared to the negative control group (4.23 ± 1.4 min). Compared to the negative control group receiving normal saline, the use of gabapentin, tramadol, and midazolam as preanesthetic medications required a lesser propofol dosage for induction but resulted in a longer recovery time. In conclusion, administering GTM before induction can effectively reduce propofol requirements, thereby enhancing cats' safety in the present study. |
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| Physical Description: | 25 leaves : illustrations ; 30 cm. |