Adhesion‑GPCRs Structure to Function /
Upon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, t...
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| Format: | Electronic eBook |
| Language: | English |
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New York, NY :
Springer US : Imprint: Springer,
2010.
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| Edition: | 1st ed. 2010. |
| Series: | Advances in Experimental Medicine and Biology,
706 |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/978-1-4419-7913-1 |
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| 245 | 1 | 0 | |a Adhesion‑GPCRs |h [electronic resource] : |b Structure to Function / |c edited by Simon Yona, Martin Stacey. |
| 250 | |a 1st ed. 2010. | ||
| 264 | 1 | |a New York, NY : |b Springer US : |b Imprint: Springer, |c 2010. | |
| 300 | |a XXI, 199 p. |b online resource. | ||
| 336 | |a text |b txt |2 rdacontent | ||
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| 490 | 1 | |a Advances in Experimental Medicine and Biology, |x 0065-2598 ; |v 706 | |
| 505 | 0 | |a The Adhesion GPCRs; Gene Repertoire, Phylogeny and Evolution -- 7TM-Cadherins: Developmental Roles and Future Challenges -- Latrophilin Signalling in Tissue Polarity and Morphogenesis -- GPS Proteolytic Cleavage of Adhesion-GPCRs -- The Latrophilins, “Split-Personality” Receptors -- Studies on the Very Large G Protein-Coupled Receptor: From Initial Discovery to Determining its Role in Sensorineural Deafness in Higher Animals -- Adhesion-GPCRs in the CNS -- GPR56 Interacts with Extracellular Matrix and Regulates Cancer Progression -- Adhesion-GPCRs in Tumorigenesis -- Immunity and Adhesion-GPCRs -- CD97 in Leukocyte Trafficking -- The Role of CD97 in Regulating Adaptive T-Cell Responses -- F4/80: The Macrophage-Specific Adhesion-GPCR and its Role in Immunoregulation -- Signal Transduction Mediated through Adhesion-GPCRs -- Emerging Roles of Brain-Specific Angiogenesis Inhibitor 1 -- Adhesion-GPCRs in the Male Reproductive Tract. | |
| 520 | |a Upon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, they transduce a signal from the ligand–receptor complex into numerous cellular responses. The importance of GPCRs is further reflected in the fact that they constitute the most common target for therapeutic drugs across a 2 wide range of human disorders. Phylogenetic analysis of GPCRs produced the GRAFS classification system, which subdivides GPCRs into five discrete families: glutamate, rhodopsin, adhesion, frizzled/taste2 and secretin receptors. The adhesion-GPCR family 2 can be further subdivided into eight groups. The field of adhesion-GPCR biology has indeed become large enough to require a volume dedicated solely to this field. The contributors to this book have made a courageous effort to address the key concepts of adhesion-GPCR biology, including the evolution and biochemistry of adhesion-GPCRs; there are extensive discussions on the functional nature of these receptors during development, the immune response and tumourgenesis. Finally, there are chapters dedicated to adhesion-GPCR signalling, an area of intense investigation. | ||
| 650 | 0 | |a Human physiology. | |
| 650 | 0 | |a Medicine. | |
| 650 | 0 | |a Molecular biology. | |
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| 650 | 2 | 4 | |a Biomedicine, general. |0 https://scigraph.springernature.com/ontologies/product-market-codes/B0000X |
| 650 | 2 | 4 | |a Molecular Medicine. |0 https://scigraph.springernature.com/ontologies/product-market-codes/B1700X |
| 700 | 1 | |a Yona, Simon. |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
| 700 | 1 | |a Stacey, Martin. |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
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| 776 | 0 | 8 | |i Printed edition: |z 9781441979148 |
| 776 | 0 | 8 | |i Printed edition: |z 9781441979124 |
| 830 | 0 | |a Advances in Experimental Medicine and Biology, |x 0065-2598 ; |v 706 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/978-1-4419-7913-1 |
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| 950 | |a Biomedical and Life Sciences (SpringerNature-11642) | ||
| 950 | |a Biomedical and Life Sciences (R0) (SpringerNature-43708) | ||