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Sequential Experimentation in Clinical Trials Design and Analysis /

This book presents an integrated methodology for sequential experimentation in clinical trials. The methodology allows sequential learning during the course of a trial to improve the efficiency of the trial design, which often lacks adequate information at the planning stage. Adaptation via sequenti...

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Bibliographic Details
Main Authors: Bartroff, Jay. (Author, http://id.loc.gov/vocabulary/relators/aut), Lai, Tze Leung. (http://id.loc.gov/vocabulary/relators/aut), Shih, Mei-Chiung. (http://id.loc.gov/vocabulary/relators/aut)
Corporate Author: SpringerLink (Online service)
Format: Electronic eBook
Language:English
Published: New York, NY : Springer New York : Imprint: Springer, 2013.
Edition:1st ed. 2013.
Series:Springer Series in Statistics, 298
Subjects:
Statistics .
Statistics for Life Sciences, Medicine, Health Sciences.
Statistics, general.
Statistical Theory and Methods.
Online Access:https://doi.org/10.1007/978-1-4614-6114-2
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Table of Contents:
  • Introduction
  • Nonlinear Regression, Experimental Design, and Phase I Clinical Trials
  • Sequential Testing Theory and Stochastic Optimization over Time
  • Group Sequential Design of Phase II and III Trials
  • Sequential Methods for Vaccine Safety Evaluation and Surveillance in Public Health
  • Time-Sequential Design of Clinical Trials with Failure-Time Endpoints
  • Confidence Intervals and p-Values
  • Adaptive Design of Confirmatory Trials
  • References.

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