Discovering and Developing Molecules with Optimal Drug-Like Properties
This authoritative volume provides a contemporary view on the latest research in molecules with optimal drug-like properties. It is a valuable source to access current best practices as well as new research techniques and strategies. Written by leading scientists in their fields, the text consists o...
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| Other Authors: | , , , |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
New York, NY :
Springer New York : Imprint: Springer,
2015.
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| Edition: | 1st ed. 2015. |
| Series: | AAPS Advances in the Pharmaceutical Sciences Series,
15 |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/978-1-4939-1399-2 |
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Table of Contents:
- 1 Developability Assessment and Risk Management During Drug Discovery
- 2 Discovery Formulations – Approaches and Practices in Early Preclinical Development
- 3 Enabling Discovery Through Leveraging and Miniaturizing Pharmaceutical Principles and Processes
- 4 Diagnosing Biopharmaceutical Limitations
- 5 The Importance of Molecular Design Principles in Delivering High Quality Pharmaceutical Candidates
- 6 Predictive Approaches to Establishing, Understanding, and Communicating Risk with Emphasis on Early Development
- 7 Strategies and Methods for Drug Candidate Phase Optimization in Discovery Space
- 8 Efficient Laboratory Methods to Assess Risk and Design Formulations
- 9 Advanced X-ray Analytical Methods to Understand Structure, Properties and Risk
- 10 Performance and Characterization of Amorphous Solid Dispersions: An Overview
- 11 Hot-Melt Extrusion: The Process-Product-Performance Interplay
- 12 Practical Considerations for Spray Dried Formulation and Process Development
- 13 Nanosizing: “End-to-End” Formulation Strategy for Poorly-Water- Soluble Molecules
- 14 Leveraging Solid State Form and Physiochemical Properties for Early Clinical Formulation Efforts: Opportunities and Challenges during Telcagepant Liquid Capsule Development.