Checkpoint Controls and Cancer Volume 1: Reviews and Model Systems /
Intracellular checkpoint controls constitute a network of signal transduction pathways that protect cells from external stresses and internal errors by means of cell cycle arrest, DNA repair, or apoptosis. Failure of this machinery can lead to embryonic death, genetic diseases, and cancer. In Checkp...
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| Format: | Electronic eBook |
| Language: | English |
| Published: |
Totowa, NJ :
Humana Press : Imprint: Humana,
2004.
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| Edition: | 1st ed. 2004. |
| Series: | Methods in Molecular Biology,
280 |
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| Online Access: | https://doi.org/10.1385/1592597882 |
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Table of Contents:
- Reviews of Checkpoint Controls, Their Involvement in the Development of Cancer, and Approaches to Their Investigation
- G1 and S-Phase Checkpoints, Chromosome Instability, and Cancer
- Analyzing the G2/M Checkpoint
- Analyzing the Spindle Checkpoint in Yeast and Frogs
- Cell Cycle Checkpoint Control Mechanisms That Can Be Disrupted in Cancer
- Analyzing Checkpoint Controls in Diverse Model Systems
- Establishment of a Cell-Free System to Study the Activation of Chk2
- Analyzing Checkpoint Controls in Human Skin
- Generation and Analysis of Brca1 Conditional Knockout Mice
- Analysis of Cell Cycle Progression and Genomic Integrity in Early Lethal Knockouts
- Xenopus Cell-Free Extracts to Study the DNA Damage Response
- A Xenopus Cell-Free System for Functional Analysis of the Chfr Ubiquitin Ligase Involved in Control of Mitotic Entry
- Control of Mitotic Entry After DNA Damage in Drosophila
- Methods for Analyzing Checkpoint Responses in Caenorhabditis elegans
- Assaying the Spindle Checkpoint in the Budding Yeast Saccharomyces cerevisiae
- Purification and Analysis of Checkpoint Protein Complexes From Saccharomyces cerevisiae.