Structure-Based Drug Discovery
The last decade has seen the confluence of several enabling technologies that have allowed protein crystallographic methods to live up to their true potential. Taken together, the numerous recent advances have made it possible to tackle difficult biological targets with a high probability of success...
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| 企業作者: | |
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| 其他作者: | |
| 格式: | 電子 電子書 |
| 語言: | English |
| 出版: |
Totowa, NJ :
Humana Press : Imprint: Humana,
2012.
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| 版: | 1st ed. 2012. |
| 叢編: | Methods in Molecular Biology,
841 |
| 主題: | |
| 在線閱讀: | https://doi.org/10.1007/978-1-61779-520-6 |
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書本目錄:
- The Utility of Structural Biology in Drug Discovery
- Genetic Construct Design and Recombinant Protein Expression for Structural Biology
- Purification of Proteins for Crystallographic Applications
- Protein Crystallization for Structure-Based Drug Design
- X-Ray Sources and High-Throughput Data Collection Methods
- The Use of Molecular Graphics in Structure-Based Drug Design
- Crystallographic Fragment Screening
- The Role of Enzymology in a Structure-Based Drug Discovery Program: Bacterial DNA Gyrase
- Leveraging Structural Information for the Discovery of New Drugs: Computational Methods
- Chemical Informatics – Using Molecular Shape Descriptors in Structure-Based Drug Design
- Accounting for Solvent in Structure-Based Drug Design
- Structure-Based Drug Design on Membrane Protein Targets: Human Integral Membrane Protein 5-Lipoxygenase-Activating Protein
- Application of SBDD to the Discovery of New Antibacterial Drugs
- Leveraging SBDD in Protein Therapeutic Development: Antibody Engineering
- A Medicinal Chemistry Perspective on Structure-Based Drug Design and Development.