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SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

This SpringerBrief explores the physiological roles of Skp1-Cullin1-F-box Complex (SCF) and Anaphase Promoting Complex (APC) in normal cells and in tumor formation. These two related, multi-subunit E3 ubiquitin ligase enzymes, APC and SCF are thought to be the major driving forces governing proper c...

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Bibliographic Details
Main Authors: Inuzuka, Hiroyuki. (Author, http://id.loc.gov/vocabulary/relators/aut), Wei, Wenyi. (http://id.loc.gov/vocabulary/relators/aut)
Corporate Author: SpringerLink (Online service)
Format: Electronic eBook
Language:English
Published: Cham : Springer International Publishing : Imprint: Springer, 2014.
Edition:1st ed. 2014.
Series:SpringerBriefs in Cancer Research,
Subjects:
Cancer research.
Cell cycle.
Proteins .
Cancer Research.
Cell Cycle Analysis.
Protein Structure.
Online Access:https://doi.org/10.1007/978-3-319-05026-3
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Table of Contents:
  • 1. Introduction
  • 2. The Fbxw subclass of SCF E3 ubiquitin Ligases
  • 3. The FbxL subclass of SCF E3 ubiquitin Ligases
  • 4. The Fbxo subclass of SCF E3 ubiquitin Ligases
  • 5. APC/Cdc20 and APC/Cdh1 E3 ubiquitin Ligases
  • 6. Conclusions and Future Perspectives.

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