T Cell Activation by CD1 and Lipid Antigens
For decades, T cells were thought to solely respond to protein-derived antigens. However, the discovery of the CD1 antigen presenting system shows how antigen presenting cells can display lipid antigens to T cells. Crystal structures show that CD1 proteins accomplish this function by inserting lipid...
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| Format: | Electronic eBook |
| Language: | English |
| Published: |
Berlin, Heidelberg :
Springer Berlin Heidelberg : Imprint: Springer,
2007.
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| Edition: | 1st ed. 2007. |
| Series: | Current Topics in Microbiology and Immunology,
314 |
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| Online Access: | https://doi.org/10.1007/978-3-540-69511-0 |
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Table of Contents:
- Molecular Biology
- Evolutionary Biology of CD1
- Architecture of CD1 Proteins
- Structure and Biology of Self Lipid Antigens
- Structures and Functions of Microbial Lipid Antigens Presented by CD1
- Cellular Biology
- CD1 Expression on Antigen-Presenting Cells
- Pathways of CD1 and Lipid Antigen Delivery, Trafficking, Processing, Loading, and Presentation
- TCR-Mediated Recognition of Glycolipid CD1 Complexes
- Development and Selection of V?14i NKT Cells
- Disease
- CD1-Restricted T Cells in Host Defense to Infectious Diseases
- NKT Cells and Autoimmune Diseases: Unraveling the Complexity
- iNKT Cells in Allergic Disease
- CD1-Restricted T Cells and Tumor Immunity
- Harnessing NKT Cells for Therapeutic Applications.