Antibody Engineering Volume 2
Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity. Antibody Engineering p...
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| Other Authors: | , |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Berlin, Heidelberg :
Springer Berlin Heidelberg : Imprint: Springer,
2010.
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| Edition: | 2nd ed. 2010. |
| Series: | Springer Protocols Handbooks,
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| Subjects: | |
| Online Access: | https://doi.org/10.1007/978-3-642-01147-4 |
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Table of Contents:
- Bioinformatics of Antigen-binding Sites
- Analysis of Single Chain Antibody Sequences Using the VBASE2 Fab Analysis Tool
- Standardized Sequence and Structure Analysis of Antibody Using IMGT®
- Protein Sequence and Structure Analysis of Antibody Variable Domains
- Generation of Antibody Fragments and Their Derivatives
- scFv by Two-Step Cloning
- Bivalent Diabodies
- Generation of Single-Chain Fv Fragments and Multivalent Derivatives scFv-Fc and scFv-CH3 (Minibodies)
- Miniantibodies
- Generation of Stably Transfected Eukaryotic Cell Lines Producing ImmunoRNAse Fusion Proteins
- Antibody–Cytokine Fusion Proteins with Members of the TNF-Family
- Recombinant Immunotoxins for Treating Cancer
- T Bodies
- Expressing Intrabodies in Mammalian Cells
- Phenotypic Knockdown with Intrabodies
- Disulfide-Stabilized Fv Fragments
- PEGylation of Antibody Fragments to Improve Pharmacodynamics and Pharmacokinetics
- Fusion Proteins with Improved PK
- In Vivo Biotinylated scFv Fragments
- Bispecific Diabodies and Single-Chain Diabodies
- Generation and Characterization of a Dual Variable Domain Immunoglobulin (DVD-Ig™) Molecule
- Isolation of Antigen-Specific Nanobodies
- CDR-FR Peptides
- Production of Antibody Fragments
- Purification and Characterization of His-Tagged Antibody Fragments
- Production of Antibody Fragments in the Gram-Positive Bacterium Bacillus megaterium
- Analysis and Purification of Antibody Fragments Using Protein A, Protein G, and Protein L
- Purification and Analysis of Strep-tagged Antibody-Fragments
- Production of Antibodies and Antibody Fragments in Escherichia coli
- Improving Expression of scFv Fragments by Co-expression of Periplasmic Chaperones
- Bioreactor Production of scFv Fragments in Pichia pastoris
- Expression of Antibody Fragments in Transgenic Plants
- Transient Production of scFv-Fc Fusion Proteins in Mammalian Cells
- Recombinant Antibody Molecules in Nanobiotechnology and Proteomics
- Immunoliposomes
- Targeted Polymeric Nanoparticles
- Antibody Microarrays for Expression Analysis
- Evaluation of Recombinant Antibodies on Protein Microarrays Applying the Multiple Spotting Technique
- Preclinical and Clinical Development
- Xenograft Mouse Models for Tumour Targeting
- Xenograft Mouse Models for Tumour Targeting
- Imaging Tumor Xenografts Using Radiolabeled Antibodies
- Human Anti-antibody Response
- IP Issues in the Therapeutic Antibody Industry.