Turning up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation
Despite tremendous advances in the understanding of the sensory nervous system which have accompanied the recent explosive growth of the neurosciences, rema- ably few innovative medicines directed towards pain and inflammation are ava- able. Indeed, many patients are still prescribed analgesic and a...
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| Other Authors: | , |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Basel :
Birkhäuser Basel : Imprint: Birkhäuser,
2005.
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| Edition: | 1st ed. 2005. |
| Series: | Progress in Inflammation Research,
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| Subjects: | |
| Online Access: | https://doi.org/10.1007/3-7643-7379-2 |
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Table of Contents:
- Historical perspective on capsaicin and its receptor
- Hot peppers, pain and analgesics
- Molecular and cellular properties of vanilloid receptors
- Structural determinants of TRPV1 functionality
- TRPV1 distribution and regulation
- Pharmacology and physiology of vanilloid receptors
- Insights into TRPV1 pharmacology provided by non-capsaicin ligands
- Endocannabinoids and vanilloid TRPV1 receptors
- Vanilloid receptor-mediated hyperalgesia and desensitization
- Capsaicin in human experimental pain models of skin, muscle and visceral sensitization
- Vanilloid receptor involvement in disease states
- TRPV1 in gut function, abdominal pain and functional bowel disorders
- TRPV1 in the airways
- Therapeutic potential of vanilloid agonists and antagonists
- TRPV1 agonist-based therapies: mechanism of action and clinical prospects
- TRPV1 agonist therapies in bladder diseases
- TRPV1 antagonists and chronic pain.