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Chemical Constituents and Cytotoxic Activity of Silver Comet (Globba pendula)

In a continuation of our chemical and biological investigations on Zingiberaceae species, we have now studied Globba pendula, a less common ginger plant found in Peninsula Malaysia. This plant has been used traditionally as a protective medicine after childbirth and for treating stomach complaints....

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Main Author: Maulidiani,
Format: Thesis
Language:English
Published: 2007
Online Access:http://ethesis.upm.edu.my/id/eprint/1275/1/IB_2007_1_F.pdf
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spelling oai:ethesis.upm.edu.my:1275 http://ethesis.upm.edu.my/id/eprint/1275/ Chemical Constituents and Cytotoxic Activity of Silver Comet (Globba pendula) Maulidiani, In a continuation of our chemical and biological investigations on Zingiberaceae species, we have now studied Globba pendula, a less common ginger plant found in Peninsula Malaysia. This plant has been used traditionally as a protective medicine after childbirth and for treating stomach complaints. No biological activity and chemical constituents have been reported on this species so far. Five of eight extracts including dichloromethane (rhizome and leaf), ethyl acetate (rhizome and leaf), and hexane (leaf) from the sequential extraction of Globba pendula were evaluated for cytotoxic activity. They exhibited cytotoxicity against MCF-7 cells (human breast cancer) with IC50 values ranging from 19.5 to 37.0 μg/ml. The statistical analysis of variance (ANOVA) showed that there were no significant (P<0.05) difference of the cytotoxic activity among the extracts. Phytochemical studies on the rhizomes and leaves of Globba pendula resulted in the isolation of two new compounds. They are 16-oxo-(8)17-12-labdadien-15,11-olide (92) and benzofuran-2-carboxaldehyde (96), along with seven known compounds: 4-hydroxy- 3-methoxybenzoic acid (69), β-sitosterol (73), β-sitosteryl-β-D-glucopyranoside (90), 7α-hydroxysitosterol (91), 3,14,19-trihydroxy-8(17),12-labdadien-16,15-olide (93), 4-hydroxy-3-methoxybenzaldehyde (94), and 2(3H)-benzoxazolone (95). The structures of isolated compounds were established based on spectroscopic data and comparison with the literature. The compound 3,14,19-trihydroxy-8(17),12- labdadien-16,15-olide (94) has demonstrated strong cytotoxic properties towards a panel of cancer cell lines (MCF-7, PC-3, and H-460) with the IC50 values of 7.9, 8.7, and 9.0 μM, respectively. 2007 Thesis NonPeerReviewed application/pdf en http://ethesis.upm.edu.my/id/eprint/1275/1/IB_2007_1_F.pdf Maulidiani, (2007) Chemical Constituents and Cytotoxic Activity of Silver Comet (Globba pendula). Masters thesis, Universiti Putra Malaysia. (IB 2007 1).
institution UPM eTHESES
collection UPM eTHESES
language English
description In a continuation of our chemical and biological investigations on Zingiberaceae species, we have now studied Globba pendula, a less common ginger plant found in Peninsula Malaysia. This plant has been used traditionally as a protective medicine after childbirth and for treating stomach complaints. No biological activity and chemical constituents have been reported on this species so far. Five of eight extracts including dichloromethane (rhizome and leaf), ethyl acetate (rhizome and leaf), and hexane (leaf) from the sequential extraction of Globba pendula were evaluated for cytotoxic activity. They exhibited cytotoxicity against MCF-7 cells (human breast cancer) with IC50 values ranging from 19.5 to 37.0 μg/ml. The statistical analysis of variance (ANOVA) showed that there were no significant (P<0.05) difference of the cytotoxic activity among the extracts. Phytochemical studies on the rhizomes and leaves of Globba pendula resulted in the isolation of two new compounds. They are 16-oxo-(8)17-12-labdadien-15,11-olide (92) and benzofuran-2-carboxaldehyde (96), along with seven known compounds: 4-hydroxy- 3-methoxybenzoic acid (69), β-sitosterol (73), β-sitosteryl-β-D-glucopyranoside (90), 7α-hydroxysitosterol (91), 3,14,19-trihydroxy-8(17),12-labdadien-16,15-olide (93), 4-hydroxy-3-methoxybenzaldehyde (94), and 2(3H)-benzoxazolone (95). The structures of isolated compounds were established based on spectroscopic data and comparison with the literature. The compound 3,14,19-trihydroxy-8(17),12- labdadien-16,15-olide (94) has demonstrated strong cytotoxic properties towards a panel of cancer cell lines (MCF-7, PC-3, and H-460) with the IC50 values of 7.9, 8.7, and 9.0 μM, respectively.
format Thesis
author Maulidiani,
spellingShingle Maulidiani,
Chemical Constituents and Cytotoxic Activity of Silver Comet (Globba pendula)
author_facet Maulidiani,
author_sort Maulidiani,
title Chemical Constituents and Cytotoxic Activity of Silver Comet (Globba pendula)
title_short Chemical Constituents and Cytotoxic Activity of Silver Comet (Globba pendula)
title_full Chemical Constituents and Cytotoxic Activity of Silver Comet (Globba pendula)
title_fullStr Chemical Constituents and Cytotoxic Activity of Silver Comet (Globba pendula)
title_full_unstemmed Chemical Constituents and Cytotoxic Activity of Silver Comet (Globba pendula)
title_sort chemical constituents and cytotoxic activity of silver comet (globba pendula)
publishDate 2007
url http://ethesis.upm.edu.my/id/eprint/1275/1/IB_2007_1_F.pdf
_version_ 1819310120817917952
score 13.4562235

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