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Chemical Constituent of Murraya Paniculata (Rutaceae) and Their Biological Activities

An investigation on the plant of Murraya paniculata, employing extraction of the leaves and stem barks and various chromatographic isolation techniques have been used. The structure of the compounds were elucidated by using spectroscopic techniques such as IR, NMR, MS and also by comparison with the...

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Main Author: Syed Abd. Azziz, Saripah Salbiah
Format: Thesis
Language:English
Published: 1998
Online Access:http://ethesis.upm.edu.my/id/eprint/4333/1/FSAS_1998_12_F.pdf
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spelling oai:ethesis.upm.edu.my:4333 http://ethesis.upm.edu.my/id/eprint/4333/ Chemical Constituent of Murraya Paniculata (Rutaceae) and Their Biological Activities Syed Abd. Azziz, Saripah Salbiah An investigation on the plant of Murraya paniculata, employing extraction of the leaves and stem barks and various chromatographic isolation techniques have been used. The structure of the compounds were elucidated by using spectroscopic techniques such as IR, NMR, MS and also by comparison with the previous work. Extraction and isolation work of the leaves and stem barks of Murraya paniculata collected from Lenggong, Perak yielded gardenin E (28), 3',4',5,5', 7-pentamethoxyflavone (29), 3',4',5,5', 7,8-hexamethoxyflavone (30), gardenin A (31), sterol mixtures (32), 3',4',5,5',7-pentamethoxyflavanone (33) and gardenin C (34). Further study on the leaves of the same plant collected from different location in lpoh, Perak afforded four known coumarins ; auraptene (36), gleinadiene (37), 5,7-dimethoxy-8-(3-methyl-2-oxo-butyl)coumalin (38) and toddalenone (39). The antibacterial and antifungi activities test were also carried out on elUde PE, CHCh and MeOH extracts of the leaves and stem barks and also towards pure compounds. This antibacterial activity was tested using the 'disk Diffusion' method. One gram positive bacteria (Baccilus cereus) and four fungi (Aspergillus ochraceous, Saccharomyces lipolytica, Saccharomyces cerevisiae dan Candida lipolytica) were selected for this test. Chloroform extract of Murraya paniculata gave the highest average zone of inhibition, indicating the degree of its sensitivity. Meanwhile compound (37) showed moderate degree of toxicity towards the bacteria. 1998 Thesis NonPeerReviewed application/pdf en http://ethesis.upm.edu.my/id/eprint/4333/1/FSAS_1998_12_F.pdf Syed Abd. Azziz, Saripah Salbiah (1998) Chemical Constituent of Murraya Paniculata (Rutaceae) and Their Biological Activities. Masters thesis, Universiti Putra Malaysia. (FSAS 1998 12).
institution UPM eTHESES
collection UPM eTHESES
language English
description An investigation on the plant of Murraya paniculata, employing extraction of the leaves and stem barks and various chromatographic isolation techniques have been used. The structure of the compounds were elucidated by using spectroscopic techniques such as IR, NMR, MS and also by comparison with the previous work. Extraction and isolation work of the leaves and stem barks of Murraya paniculata collected from Lenggong, Perak yielded gardenin E (28), 3',4',5,5', 7-pentamethoxyflavone (29), 3',4',5,5', 7,8-hexamethoxyflavone (30), gardenin A (31), sterol mixtures (32), 3',4',5,5',7-pentamethoxyflavanone (33) and gardenin C (34). Further study on the leaves of the same plant collected from different location in lpoh, Perak afforded four known coumarins ; auraptene (36), gleinadiene (37), 5,7-dimethoxy-8-(3-methyl-2-oxo-butyl)coumalin (38) and toddalenone (39). The antibacterial and antifungi activities test were also carried out on elUde PE, CHCh and MeOH extracts of the leaves and stem barks and also towards pure compounds. This antibacterial activity was tested using the 'disk Diffusion' method. One gram positive bacteria (Baccilus cereus) and four fungi (Aspergillus ochraceous, Saccharomyces lipolytica, Saccharomyces cerevisiae dan Candida lipolytica) were selected for this test. Chloroform extract of Murraya paniculata gave the highest average zone of inhibition, indicating the degree of its sensitivity. Meanwhile compound (37) showed moderate degree of toxicity towards the bacteria.
format Thesis
author Syed Abd. Azziz, Saripah Salbiah
spellingShingle Syed Abd. Azziz, Saripah Salbiah
Chemical Constituent of Murraya Paniculata (Rutaceae) and Their Biological Activities
author_facet Syed Abd. Azziz, Saripah Salbiah
author_sort Syed Abd. Azziz, Saripah Salbiah
title Chemical Constituent of Murraya Paniculata (Rutaceae) and Their Biological Activities
title_short Chemical Constituent of Murraya Paniculata (Rutaceae) and Their Biological Activities
title_full Chemical Constituent of Murraya Paniculata (Rutaceae) and Their Biological Activities
title_fullStr Chemical Constituent of Murraya Paniculata (Rutaceae) and Their Biological Activities
title_full_unstemmed Chemical Constituent of Murraya Paniculata (Rutaceae) and Their Biological Activities
title_sort chemical constituent of murraya paniculata (rutaceae) and their biological activities
publishDate 1998
url http://ethesis.upm.edu.my/id/eprint/4333/1/FSAS_1998_12_F.pdf
_version_ 1819310472024817664
score 13.4562235

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