Safety assessment of tocotrienol supplementation in subjects with metabol syndrome: a randomised control trial
Previous studies have reported that tocotrienols (T3) possess many distinct properties such as antioxidant, cardioprotective, neuroprotective, anti-cancer, anti-inflammatory and anti-angiogenic, which are beneficial for the improvement of human health. However, there is limited data available on the...
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oai:http:--agris.upm.edu.my:0-17130Safety assessment of tocotrienol supplementation in subjects with metabol syndrome: a randomised control trialKanga Rani SelvadurayPuvaneswari MeganathanFu, Ju YenKalanithi NesaretnamYuen, Kah HayLai, Oi MingGan, Yee LinChew, Boon HowTeng, Kim-TiuTocotrienolsVitamin eSupplementsHuman diseasesMetabolic disordersAbsorptionBlood samplingCentrifugationBody weightStatistical analysisAnalytical methodsDosageSafetyPrevious studies have reported that tocotrienols (T3) possess many distinct properties such as antioxidant, cardioprotective, neuroprotective, anti-cancer, anti-inflammatory and anti-angiogenic, which are beneficial for the improvement of human health. However, there is limited data available on the safety assessment of T3 compared to tocopherols (T). A randomised, double-blinded, cross-over and placebo-controlled human clinical trial was conducted to determine the safety and tolerance of T3 supplementation in 31 subjects with metabolic syndrome. The subjects were supplemented with tocotrienol-rich fraction (TRF) 200 mg or placebo capsules twice daily for two weeks followed by a post-intervention visit. Results showed that T3 supplementation had no significant adverse effect on the red blood cell (RBC), white blood cell (WBC) and platelet counts between TRF (5.10 ± 0.78 x 1012 litre-1, 7.35 ± 1.59 x 109 litre-1, 279.45 ± 73.86 x 109 litre-1, respectively) and placebo interventions (5.13 ± 0.76 x 1012 litre-1, 7.25 ± 1.95 x 109 litre-1, 267.45 ± 68.72 x 109 litre-1, respectively). Measures of serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT)) and albumin did not differ between TRF (25.68 ± 10.72 IU litre-1, 38.26 ± 24.74 IU litre-1, 43.61 ± 2.26 g litre-1, respectively) and placebo interventions (27.39 ± 16.44 IU litre-1, 42.23 ± 33.58 IU litre-1, 43.68 ± 2.15 g litre-1, respectively).This study indicated that supplementation with T3 at the dosage of 400 mg per day for 14 days did not induce haematoxicity and hepatotoxicity in subjects with metabolic syndrome.2020-03-20T03:50:50Z2020-03-20T03:50:50Z2016Journal ContributionArticleNon-RefereedJournal of Oil Palm Research, 28 (1), p. 34-431511-2780http://agris.upm.edu.my:8080/dspace/handle/0/17130MY2020050436enhttp://jopr.mpob.gov.my/safety-assessment-of-tocotrienol-supplementat-ion-in-subjects-with-metabol-ic-syndrome-a-randomised-control-trial/?v=truehttps://doi.org/10.21894/jopr.2016.2801.05http://www.oceandocs.org/license |
| institution |
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AGRIS |
| language |
English |
| topic |
Tocotrienols Vitamin e Supplements Human diseases Metabolic disorders Absorption Blood sampling Centrifugation Body weight Statistical analysis Analytical methods Dosage Safety |
| spellingShingle |
Tocotrienols Vitamin e Supplements Human diseases Metabolic disorders Absorption Blood sampling Centrifugation Body weight Statistical analysis Analytical methods Dosage Safety Kanga Rani Selvaduray Puvaneswari Meganathan Fu, Ju Yen Kalanithi Nesaretnam Yuen, Kah Hay Lai, Oi Ming Gan, Yee Lin Chew, Boon How Teng, Kim-Tiu Safety assessment of tocotrienol supplementation in subjects with metabol syndrome: a randomised control trial |
| description |
Previous studies have reported that tocotrienols (T3) possess many distinct properties such as antioxidant, cardioprotective, neuroprotective, anti-cancer, anti-inflammatory and anti-angiogenic, which are beneficial for the improvement of human health. However, there is limited data available on the safety assessment of T3 compared to tocopherols (T). A randomised, double-blinded, cross-over and placebo-controlled human clinical trial was conducted to determine the safety and tolerance of T3 supplementation in 31 subjects with metabolic syndrome. The subjects were supplemented with tocotrienol-rich fraction (TRF) 200 mg or placebo capsules twice daily for two weeks followed by a post-intervention visit. Results showed that T3 supplementation had no significant adverse effect on the red blood cell (RBC), white blood cell (WBC) and platelet counts between TRF (5.10 ± 0.78 x 1012 litre-1, 7.35 ± 1.59 x 109 litre-1, 279.45 ± 73.86 x 109 litre-1, respectively) and placebo interventions (5.13 ± 0.76 x 1012 litre-1, 7.25 ± 1.95 x 109 litre-1, 267.45 ± 68.72 x 109 litre-1, respectively). Measures of serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT)) and albumin did not differ between TRF (25.68 ± 10.72 IU litre-1, 38.26 ± 24.74 IU litre-1, 43.61 ± 2.26 g litre-1, respectively) and placebo interventions (27.39 ± 16.44 IU litre-1, 42.23 ± 33.58 IU litre-1, 43.68 ± 2.15 g litre-1, respectively).This study indicated that supplementation with T3 at the dosage of 400 mg per day for 14 days did not induce haematoxicity and hepatotoxicity in subjects with metabolic syndrome. |
| format |
Journal Contribution |
| author |
Kanga Rani Selvaduray Puvaneswari Meganathan Fu, Ju Yen Kalanithi Nesaretnam Yuen, Kah Hay Lai, Oi Ming Gan, Yee Lin Chew, Boon How Teng, Kim-Tiu |
| author_facet |
Kanga Rani Selvaduray Puvaneswari Meganathan Fu, Ju Yen Kalanithi Nesaretnam Yuen, Kah Hay Lai, Oi Ming Gan, Yee Lin Chew, Boon How Teng, Kim-Tiu |
| author_sort |
Kanga Rani Selvaduray |
| title |
Safety assessment of tocotrienol supplementation in subjects with metabol syndrome: a randomised control trial |
| title_short |
Safety assessment of tocotrienol supplementation in subjects with metabol syndrome: a randomised control trial |
| title_full |
Safety assessment of tocotrienol supplementation in subjects with metabol syndrome: a randomised control trial |
| title_fullStr |
Safety assessment of tocotrienol supplementation in subjects with metabol syndrome: a randomised control trial |
| title_full_unstemmed |
Safety assessment of tocotrienol supplementation in subjects with metabol syndrome: a randomised control trial |
| title_sort |
safety assessment of tocotrienol supplementation in subjects with metabol syndrome: a randomised control trial |
| publishDate |
2020 |
| url |
http://agris.upm.edu.my:8080/dspace/handle/0/17130 |
| _version_ |
1782772362538647552 |
| score |
12.933938 |