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A study on the hepatoprotective effect of Andrographis paniculata on mice

Andrographis paniculata is a well known medicinal plant of Ayurveda with various pharmacological as well as medicinal properties. The present study determined the hepatoprotective effect of crude methanolic extracts of A. paniculata on mice. The phytochemical screening of the crude methanolic extrac...

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Main Authors:	Sutha D., Jegathambigai R., Sudhakaran S.
Format:	Proceedings Paper
Language:	English
Published:	Sarawak Biodiversity Centre 2022
Subjects:	Acanthaceae Medicinal plants Herbaceous plants Leaves Methanol Phytochemistry Laboratory experimentation Thin layer chromatography Mice Liver Animal histology Protein content Tannins Terpenoids Diterpenes Alkaloids Flavonoids Medicinal properties
Online Access:	http://agris.upm.edu.my:8080/dspace/handle/0/21083
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spelling	oai:http:--agris.upm.edu.my:0-21083A study on the hepatoprotective effect of Andrographis paniculata on miceSutha D.Jegathambigai R.Sudhakaran S.AcanthaceaeMedicinal plantsHerbaceous plantsLeavesMethanolPhytochemistryLaboratory experimentationThin layer chromatographyMiceLiverAnimal histologyProtein contentTanninsTerpenoidsDiterpenesAlkaloidsFlavonoidsMedicinal propertiesAndrographis paniculata is a well known medicinal plant of Ayurveda with various pharmacological as well as medicinal properties. The present study determined the hepatoprotective effect of crude methanolic extracts of A. paniculata on mice. The phytochemical screening of the crude methanolic extracts of A. paniculata plant was also determined followed by the confirmation of the active compound using Thin Layer Chromatography. The hepatoprotective activity of methanolic extracts of A. panicufata was evaluated against paracetamol induced (500mg/kg) hepatic damage in mice. The extracts at doses of 10mg/kg and 1OOmg/kg were orally administered at 24 and 72 hours time interval n each group. Histological analysis of the liver and the liver protein content was determined. The results of the study indicated that the crude extracts of A. paniculata at both doses exhibited a significant protective effect in the liver morphology of the paracetamol induced hepatotoxicity in mice. There was also a significant decrease (P<0.05) the liver protein content of the hepatotoxic mice after the treatments. The crude methanolic extracts of A. paniculata indicated the presence of phytochemical constituents such as flavonoid, alkaloid, tannin and terpenoids. Finally, Thin Layer Chromatography confirmed the presence of active compound, diterpene lactone or andrographolide which has contributed to the hepatoprotective activity of A paniculata Hence, it can be concluded that treatment of low and high doses of A paniculata with time period revealed the hepatoprotective effect in mice.Sarawak Biodiversity CentreSarawak, Malaysia2022-06-14T09:22:19Z2022-06-14T09:22:19Z2010Proceedings PaperArticleNon-RefereedBiodiversity - Biotechnology : gateway to discoveries, sustainable utilization and wealth creation : proceedings of the International Symposium held in Kuching Sarawak, Malaysia: Kuching, Sarawak, 19-21 Nov 2008, p. 239-243978-983-4063832http://agris.upm.edu.my:8080/dspace/handle/0/21083MY2022050792enMalaysiahttp://www.oceandocs.org/license
institution	AGRIS
collection	AGRIS
language	English
topic	Acanthaceae Medicinal plants Herbaceous plants Leaves Methanol Phytochemistry Laboratory experimentation Thin layer chromatography Mice Liver Animal histology Protein content Tannins Terpenoids Diterpenes Alkaloids Flavonoids Medicinal properties
spellingShingle	Acanthaceae Medicinal plants Herbaceous plants Leaves Methanol Phytochemistry Laboratory experimentation Thin layer chromatography Mice Liver Animal histology Protein content Tannins Terpenoids Diterpenes Alkaloids Flavonoids Medicinal properties Sutha D. Jegathambigai R. Sudhakaran S. A study on the hepatoprotective effect of Andrographis paniculata on mice
description	Andrographis paniculata is a well known medicinal plant of Ayurveda with various pharmacological as well as medicinal properties. The present study determined the hepatoprotective effect of crude methanolic extracts of A. paniculata on mice. The phytochemical screening of the crude methanolic extracts of A. paniculata plant was also determined followed by the confirmation of the active compound using Thin Layer Chromatography. The hepatoprotective activity of methanolic extracts of A. panicufata was evaluated against paracetamol induced (500mg/kg) hepatic damage in mice. The extracts at doses of 10mg/kg and 1OOmg/kg were orally administered at 24 and 72 hours time interval n each group. Histological analysis of the liver and the liver protein content was determined. The results of the study indicated that the crude extracts of A. paniculata at both doses exhibited a significant protective effect in the liver morphology of the paracetamol induced hepatotoxicity in mice. There was also a significant decrease (P<0.05) the liver protein content of the hepatotoxic mice after the treatments. The crude methanolic extracts of A. paniculata indicated the presence of phytochemical constituents such as flavonoid, alkaloid, tannin and terpenoids. Finally, Thin Layer Chromatography confirmed the presence of active compound, diterpene lactone or andrographolide which has contributed to the hepatoprotective activity of A paniculata Hence, it can be concluded that treatment of low and high doses of A paniculata with time period revealed the hepatoprotective effect in mice.
format	Proceedings Paper
author	Sutha D. Jegathambigai R. Sudhakaran S.
author_facet	Sutha D. Jegathambigai R. Sudhakaran S.
author_sort	Sutha D.
title	A study on the hepatoprotective effect of Andrographis paniculata on mice
title_short	A study on the hepatoprotective effect of Andrographis paniculata on mice
title_full	A study on the hepatoprotective effect of Andrographis paniculata on mice
title_fullStr	A study on the hepatoprotective effect of Andrographis paniculata on mice
title_full_unstemmed	A study on the hepatoprotective effect of Andrographis paniculata on mice
title_sort	study on the hepatoprotective effect of andrographis paniculata on mice
publisher	Sarawak Biodiversity Centre
publishDate	2022
url	http://agris.upm.edu.my:8080/dspace/handle/0/21083
_version_	1819285492976320512
score	13.4562235

A study on the hepatoprotective effect of Andrographis paniculata on mice

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