Tocotrienols : recent findings and problems
Both tocotrienols (T3) and tocopherols (T) act as a radical-scavenging antioxidant, but the results so far reported on the in vitro relative activities as antioxidant are inconsistent. We have confirmed that the reactivities of α-, β-, γ-, and δ-T3 and the corresponding T isoforms toward free radica...
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| Format: | Proceedings Paper |
| Language: | English |
| Published: |
Malaysian Palm Oil Board
2014
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| Subjects: | |
| Online Access: | http://agris.upm.edu.my:8080/dspace/handle/0/8251 |
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| Summary: | Both tocotrienols (T3) and tocopherols (T) act as a radical-scavenging antioxidant, but the results so far reported on the in vitro relative activities as antioxidant are inconsistent. We
have confirmed that the reactivities of α-, β-, γ-, and δ-T3 and the corresponding T isoforms toward free radicals are the same and the corresponding T3 and T exert similar effects as a radical-scavenging antioxidant. The physical effects of T3 and T on the membrane fluidity and rigidity are also similar. The mobilities within the membranes of T3 and T are similar but T3 has higher mobility
between the membranes and higher rate of incorporation into the membranes than T. T3 is incorporated into cells faster than T. The cellular distribution is similar between T3 and T and it is determined by the lipid contents. T3 showed higher protective effects than the corresonding T isoforms against the oxidative cell damage induced by selenium deficiency, primarily because of the faster rate of uptake of T3 than T into the cells. T3 also
suppressed more efficiently than T the expression of adhesion molecules on endotherial cells and adhesion of monocytic cells. However, this difference is due to the different celluar
concentration, and T3 and T of the same concentrations exerted the same effects. Nonetheless, T3 exerted higher antioxidnat potency than T under certain circumstances. |
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