Staff View: Humoral response to SARS-CoV-2 vaccines among healthcare workers in a tertiary hospital in Malaysia

Humoral response to SARS-CoV-2 vaccines among healthcare workers in a tertiary hospital in Malaysia

Introduction: Healthcare workers (HCWs) were among the first to be fully vaccinated against SARS-CoV-2. However, the antibody responses to the vaccines and potential decline among Malaysian HCW are still unclear. The objective of this study is to follow-up anti-S antibody levels among HCW vaccinated...

Full description

Saved in:

Bibliographic Details
Main Authors:	Mohd Amin, Amrina, Mukhtar, Shahidah, Razak, Sofiah Hanis, Che Mamat, Mirlia Suzila, Ramasamy, Thilakaveni, Cheah, Yoke Kqueen, Mahmud, Aidalina, Mohd Taib, Niazlin, Amin Nordin, Syafinaz, Abdullah, Maha, Mohd Isa, Muhammad
Format:	Article
Published:	Malaysian Medical Association 2022
Tags:	Add Tag No Tags, Be the first to tag this record!

id	oai:psasir.upm.edu.my:101746
record_format	eprints
spelling	oai:psasir.upm.edu.my:101746 http://psasir.upm.edu.my/id/eprint/101746/ Humoral response to SARS-CoV-2 vaccines among healthcare workers in a tertiary hospital in Malaysia Mohd Amin, Amrina Mukhtar, Shahidah Razak, Sofiah Hanis Che Mamat, Mirlia Suzila Ramasamy, Thilakaveni Cheah, Yoke Kqueen Mahmud, Aidalina Mohd Taib, Niazlin Amin Nordin, Syafinaz Abdullah, Maha Mohd Isa, Muhammad Introduction: Healthcare workers (HCWs) were among the first to be fully vaccinated against SARS-CoV-2. However, the antibody responses to the vaccines and potential decline among Malaysian HCW are still unclear. The objective of this study is to follow-up anti-S antibody levels among HCW vaccinated with mRNA vaccine (BTN162b2) and inactivated vaccine (CoronaVac). Materials and Methods: Plasma samples were collected prevaccination, 2 weeks and 6 months post-vaccination and tested for total immunoglobulin levels using ELISA method. Results: A small percentage of HCW (2.2%, 15/677) had elevated anti-S antibody levels in their pre-vaccination plasma samples (median 20.4, IQR 5.8), indicating that they were exposed to SARS-CoV-2 infection prior to vaccination. The mRNA vaccine significantly increased anti-S levels of both previously infected and uninfected individuals to saturation levels (median 21.88, IQR.0.88) at 2 weeks postsecond dose of the vaccine. At 6 months post-vaccination, the antibody levels appeared to be maintained among the recipients of the mRNA vaccine. However, at this time point, anti-S antibody levels were lower in individuals given inactivated vaccine (median 20.39, IQR 7.31, n=28), and interestingly, their antibody levels were similar to anti-S levels in pre-vaccination exposed individuals. Antibody levels were not different between the sexes. Conclusion: Anti-S levels differ in individuals given the different vaccines. While further study is required to determine the threshold level for protection against SARSCoV-2, individuals with low antibody levels may be considered for boosters. Malaysian Medical Association 2022 Article PeerReviewed Mohd Amin, Amrina and Mukhtar, Shahidah and Razak, Sofiah Hanis and Che Mamat, Mirlia Suzila and Ramasamy, Thilakaveni and Cheah, Yoke Kqueen and Mahmud, Aidalina and Mohd Taib, Niazlin and Amin Nordin, Syafinaz and Abdullah, Maha and Mohd Isa, Muhammad (2022) Humoral response to SARS-CoV-2 vaccines among healthcare workers in a tertiary hospital in Malaysia. Medical Journal of Malaysia, 78 (1). pp. 20-24. ISSN 0300-5283 https://www.e-mjm.org/2023/v78n1/index.html
institution	UPM IR
collection	UPM IR
description	Introduction: Healthcare workers (HCWs) were among the first to be fully vaccinated against SARS-CoV-2. However, the antibody responses to the vaccines and potential decline among Malaysian HCW are still unclear. The objective of this study is to follow-up anti-S antibody levels among HCW vaccinated with mRNA vaccine (BTN162b2) and inactivated vaccine (CoronaVac). Materials and Methods: Plasma samples were collected prevaccination, 2 weeks and 6 months post-vaccination and tested for total immunoglobulin levels using ELISA method. Results: A small percentage of HCW (2.2%, 15/677) had elevated anti-S antibody levels in their pre-vaccination plasma samples (median 20.4, IQR 5.8), indicating that they were exposed to SARS-CoV-2 infection prior to vaccination. The mRNA vaccine significantly increased anti-S levels of both previously infected and uninfected individuals to saturation levels (median 21.88, IQR.0.88) at 2 weeks postsecond dose of the vaccine. At 6 months post-vaccination, the antibody levels appeared to be maintained among the recipients of the mRNA vaccine. However, at this time point, anti-S antibody levels were lower in individuals given inactivated vaccine (median 20.39, IQR 7.31, n=28), and interestingly, their antibody levels were similar to anti-S levels in pre-vaccination exposed individuals. Antibody levels were not different between the sexes. Conclusion: Anti-S levels differ in individuals given the different vaccines. While further study is required to determine the threshold level for protection against SARSCoV-2, individuals with low antibody levels may be considered for boosters.
format	Article
author	Mohd Amin, Amrina Mukhtar, Shahidah Razak, Sofiah Hanis Che Mamat, Mirlia Suzila Ramasamy, Thilakaveni Cheah, Yoke Kqueen Mahmud, Aidalina Mohd Taib, Niazlin Amin Nordin, Syafinaz Abdullah, Maha Mohd Isa, Muhammad
spellingShingle	Mohd Amin, Amrina Mukhtar, Shahidah Razak, Sofiah Hanis Che Mamat, Mirlia Suzila Ramasamy, Thilakaveni Cheah, Yoke Kqueen Mahmud, Aidalina Mohd Taib, Niazlin Amin Nordin, Syafinaz Abdullah, Maha Mohd Isa, Muhammad Humoral response to SARS-CoV-2 vaccines among healthcare workers in a tertiary hospital in Malaysia
author_facet	Mohd Amin, Amrina Mukhtar, Shahidah Razak, Sofiah Hanis Che Mamat, Mirlia Suzila Ramasamy, Thilakaveni Cheah, Yoke Kqueen Mahmud, Aidalina Mohd Taib, Niazlin Amin Nordin, Syafinaz Abdullah, Maha Mohd Isa, Muhammad
author_sort	Mohd Amin, Amrina
title	Humoral response to SARS-CoV-2 vaccines among healthcare workers in a tertiary hospital in Malaysia
title_short	Humoral response to SARS-CoV-2 vaccines among healthcare workers in a tertiary hospital in Malaysia
title_full	Humoral response to SARS-CoV-2 vaccines among healthcare workers in a tertiary hospital in Malaysia
title_fullStr	Humoral response to SARS-CoV-2 vaccines among healthcare workers in a tertiary hospital in Malaysia
title_full_unstemmed	Humoral response to SARS-CoV-2 vaccines among healthcare workers in a tertiary hospital in Malaysia
title_sort	humoral response to sars-cov-2 vaccines among healthcare workers in a tertiary hospital in malaysia
publisher	Malaysian Medical Association
publishDate	2022
_version_	1819301292280905728
score	13.4562235

Humoral response to SARS-CoV-2 vaccines among healthcare workers in a tertiary hospital in Malaysia

Similar Items