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Anticancer properties of sulforaphane: current insights at the molecular level

Sulforaphane (SFN) is an isothiocyanate with multiple biomedical applications. Sulforaphane can be extracted from the plants of the genus <jats:italic>Brassica</jats:italic>. However, broccoli sprouts are the chief source of sulforaphane and are 20 to 50 times richer than mature broccoli...

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Main Authors:	Asif Ali, Muhammad, Khan, Noohela, Kaleem, Nabeeha, Ahmad, Waqas, Alharethi, Salem Hussain, Alharbi, Bandar, Alhassan, Hassan H., Al-Enazi, Maher M., Razis, Ahmad Faizal Abdull, Modu, Babagana, Calina, Daniela, Sharifi-Rad, Javad
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Published:	Frontiers Media 2023
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spelling	oai:psasir.upm.edu.my:106613 http://psasir.upm.edu.my/id/eprint/106613/ Anticancer properties of sulforaphane: current insights at the molecular level Asif Ali, Muhammad Khan, Noohela Kaleem, Nabeeha Ahmad, Waqas Alharethi, Salem Hussain Alharbi, Bandar Alhassan, Hassan H. Al-Enazi, Maher M. Razis, Ahmad Faizal Abdull Modu, Babagana Calina, Daniela Sharifi-Rad, Javad Sulforaphane (SFN) is an isothiocyanate with multiple biomedical applications. Sulforaphane can be extracted from the plants of the genus <jats:italic>Brassica</jats:italic>. However, broccoli sprouts are the chief source of sulforaphane and are 20 to 50 times richer than mature broccoli as they contain 1,153 mg/100 g. SFN is a secondary metabolite that is produced as a result of the hydrolysis of glucoraphanin (a glucosinolate) by the enzyme myrosinase. This review paper aims to summarize and understand the mechanisms behind the anticancer potential of sulforaphane. The data was collected by searching PubMed/MedLine, Scopus, Web of Science, and Google Scholar. This paper concludes that sulforaphane provides cancer protection through the alteration of various epigenetic and non-epigenetic pathways. It is a potent anticancer phytochemical that is safe to consume with minimal side effects. However, there is still a need for further research regarding SFN and the development of a standard dose. Frontiers Media 2023 Article PeerReviewed Asif Ali, Muhammad and Khan, Noohela and Kaleem, Nabeeha and Ahmad, Waqas and Alharethi, Salem Hussain and Alharbi, Bandar and Alhassan, Hassan H. and Al-Enazi, Maher M. and Razis, Ahmad Faizal Abdull and Modu, Babagana and Calina, Daniela and Sharifi-Rad, Javad (2023) Anticancer properties of sulforaphane: current insights at the molecular level. Frontiers in Oncology, 13. pp. 1-9. ISSN 2234-943X; ESSN: 2234-943X https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1168321/full 10.3389/fonc.2023.1168321
institution	UPM IR
collection	UPM IR
description	Sulforaphane (SFN) is an isothiocyanate with multiple biomedical applications. Sulforaphane can be extracted from the plants of the genus <jats:italic>Brassica</jats:italic>. However, broccoli sprouts are the chief source of sulforaphane and are 20 to 50 times richer than mature broccoli as they contain 1,153 mg/100 g. SFN is a secondary metabolite that is produced as a result of the hydrolysis of glucoraphanin (a glucosinolate) by the enzyme myrosinase. This review paper aims to summarize and understand the mechanisms behind the anticancer potential of sulforaphane. The data was collected by searching PubMed/MedLine, Scopus, Web of Science, and Google Scholar. This paper concludes that sulforaphane provides cancer protection through the alteration of various epigenetic and non-epigenetic pathways. It is a potent anticancer phytochemical that is safe to consume with minimal side effects. However, there is still a need for further research regarding SFN and the development of a standard dose.
format	Article
author	Asif Ali, Muhammad Khan, Noohela Kaleem, Nabeeha Ahmad, Waqas Alharethi, Salem Hussain Alharbi, Bandar Alhassan, Hassan H. Al-Enazi, Maher M. Razis, Ahmad Faizal Abdull Modu, Babagana Calina, Daniela Sharifi-Rad, Javad
spellingShingle	Asif Ali, Muhammad Khan, Noohela Kaleem, Nabeeha Ahmad, Waqas Alharethi, Salem Hussain Alharbi, Bandar Alhassan, Hassan H. Al-Enazi, Maher M. Razis, Ahmad Faizal Abdull Modu, Babagana Calina, Daniela Sharifi-Rad, Javad Anticancer properties of sulforaphane: current insights at the molecular level
author_facet	Asif Ali, Muhammad Khan, Noohela Kaleem, Nabeeha Ahmad, Waqas Alharethi, Salem Hussain Alharbi, Bandar Alhassan, Hassan H. Al-Enazi, Maher M. Razis, Ahmad Faizal Abdull Modu, Babagana Calina, Daniela Sharifi-Rad, Javad
author_sort	Asif Ali, Muhammad
title	Anticancer properties of sulforaphane: current insights at the molecular level
title_short	Anticancer properties of sulforaphane: current insights at the molecular level
title_full	Anticancer properties of sulforaphane: current insights at the molecular level
title_fullStr	Anticancer properties of sulforaphane: current insights at the molecular level
title_full_unstemmed	Anticancer properties of sulforaphane: current insights at the molecular level
title_sort	anticancer properties of sulforaphane: current insights at the molecular level
publisher	Frontiers Media
publishDate	2023
_version_	1819301694667751424
score	13.4562235

Anticancer properties of sulforaphane: current insights at the molecular level

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