Astaxanthin as a potent antioxidant for promoting bone health: an up-to-date review
In recent years, bone loss and its associated diseases have become a significant public health concern due to increased disability, morbidity, and mortality. Oxidative stress and bone loss are correlated, where oxidative stress suppresses osteoblast activity, resulting in compromised homeostasis bet...
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Multidisciplinary Digital Publishing Institute
2023
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oai:psasir.upm.edu.my:106767 http://psasir.upm.edu.my/id/eprint/106767/ Astaxanthin as a potent antioxidant for promoting bone health: an up-to-date review Davan, Iswari Fakurazi, Sharida Alias, Ekram Ibrahim, Nurul ‘Izzah Hwei, Ng Min Hassan, Haniza In recent years, bone loss and its associated diseases have become a significant public health concern due to increased disability, morbidity, and mortality. Oxidative stress and bone loss are correlated, where oxidative stress suppresses osteoblast activity, resulting in compromised homeostasis between bone formation and resorption. This event causes upregulation of bone remodeling turnover rate with an increased risk of fractures and bone loss. Therefore, supplementation of antioxidants can be proposed to reduce oxidative stress, facilitate the bone remodeling process, suppress the initiation of bone diseases, and improve bone health. Astaxanthin (3,3′-dihydroxy-4-4′-diketo-β-β carotene), a potent antioxidant belonging to the xanthophylls family, is a potential ROS scavenger and could be a promising therapeutic nutraceutical possessing various pharmacological properties. In bone, astaxanthin enhances osteoblast differentiation, osteocytes numbers, and/or differentiation, inhibits osteoclast differentiation, cartilage degradation markers, and increases bone mineral density, expression of osteogenic markers, while reducing bone loss. In this review, we presented the up-to-date findings of the potential anabolic effects of astaxanthin on bone health in vitro, animal, and human studies by providing comprehensive evidence for its future clinical application, especially in treating bone diseases. Multidisciplinary Digital Publishing Institute 2023 Article PeerReviewed Davan, Iswari and Fakurazi, Sharida and Alias, Ekram and Ibrahim, Nurul ‘Izzah and Hwei, Ng Min and Hassan, Haniza (2023) Astaxanthin as a potent antioxidant for promoting bone health: an up-to-date review. Antioxidants, 12 (7). pp. 1-26. ISSN 2076-3921 https://www.mdpi.com/2076-3921/12/7/1480 10.3390/antiox12071480 |
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In recent years, bone loss and its associated diseases have become a significant public health concern due to increased disability, morbidity, and mortality. Oxidative stress and bone loss are correlated, where oxidative stress suppresses osteoblast activity, resulting in compromised homeostasis between bone formation and resorption. This event causes upregulation of bone remodeling turnover rate with an increased risk of fractures and bone loss. Therefore, supplementation of antioxidants can be proposed to reduce oxidative stress, facilitate the bone remodeling process, suppress the initiation of bone diseases, and improve bone health. Astaxanthin (3,3′-dihydroxy-4-4′-diketo-β-β carotene), a potent antioxidant belonging to the xanthophylls family, is a potential ROS scavenger and could be a promising therapeutic nutraceutical possessing various pharmacological properties. In bone, astaxanthin enhances osteoblast differentiation, osteocytes numbers, and/or differentiation, inhibits osteoclast differentiation, cartilage degradation markers, and increases bone mineral density, expression of osteogenic markers, while reducing bone loss. In this review, we presented the up-to-date findings of the potential anabolic effects of astaxanthin on bone health in vitro, animal, and human studies by providing comprehensive evidence for its future clinical application, especially in treating bone diseases. |
| format |
Article |
| author |
Davan, Iswari Fakurazi, Sharida Alias, Ekram Ibrahim, Nurul ‘Izzah Hwei, Ng Min Hassan, Haniza |
| spellingShingle |
Davan, Iswari Fakurazi, Sharida Alias, Ekram Ibrahim, Nurul ‘Izzah Hwei, Ng Min Hassan, Haniza Astaxanthin as a potent antioxidant for promoting bone health: an up-to-date review |
| author_facet |
Davan, Iswari Fakurazi, Sharida Alias, Ekram Ibrahim, Nurul ‘Izzah Hwei, Ng Min Hassan, Haniza |
| author_sort |
Davan, Iswari |
| title |
Astaxanthin as a potent antioxidant for promoting bone health: an up-to-date review |
| title_short |
Astaxanthin as a potent antioxidant for promoting bone health: an up-to-date review |
| title_full |
Astaxanthin as a potent antioxidant for promoting bone health: an up-to-date review |
| title_fullStr |
Astaxanthin as a potent antioxidant for promoting bone health: an up-to-date review |
| title_full_unstemmed |
Astaxanthin as a potent antioxidant for promoting bone health: an up-to-date review |
| title_sort |
astaxanthin as a potent antioxidant for promoting bone health: an up-to-date review |
| publisher |
Multidisciplinary Digital Publishing Institute |
| publishDate |
2023 |
| _version_ |
1819301704687943680 |
| score |
13.4562235 |