Some Physical And Chemical Properties Of The Bioactive Components Responsible For Antinociceptive Activity Of Haruan (Channa Striatus) Extracts
Haruan (Channa striatus) fillet and mucus extracts have been proven to exhibit a dosedependent antinociceptive activity and enhanced morphine effect. This current study is to establish some of the physical and chemical properties of the bioactive components responsible for haruan antinociceptive...
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| Format: | Thesis |
| Language: | English English |
| Published: |
2001
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| Online Access: | http://psasir.upm.edu.my/id/eprint/11213/1/FPSK_M_2001_3_A.pdf |
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| Summary: | Haruan (Channa striatus) fillet and mucus extracts have been proven to exhibit a dosedependent
antinociceptive activity and enhanced morphine effect.
This current study is to establish some of the physical and chemical properties of the
bioactive components responsible for haruan antinociceptive activity. Five types of
solvents (water, methanol, ethanol, chloroform and chloroform:methanol) were used
to extract the respective components from freeze-dried haruan fillet. Various salts
(NaCI, K Cl, CaCh, MgCh and their combinations (MS» were used to study the
involvement of ionic components in mediating the antinociceptive activity of haruan
extract. The aqueous portion obtained after a chloroform:methanol extraction of fresh
haruan fillet was filtered using three types of Millipore filters (30,000, 10,000 and
5,000 Nominal Molecular Weight Limit (NMWL), respectively. Lastly, the aqueous
portion, filtered using the 5,000 NMWL Millipore filters, was purified using the High |
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