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Antinociceptive and antiinflammatory activities of the aqueous extract of Trigonopleura malayana resin in experimental animal models.

Trigonopleura malayana L. (Euphorbiaceae) resin, locally known as Gambir Sarawak, has been used traditionally to alleviate pain associated with insect bites, muscle ache, toothache and minor injuries. The present study was carried out using various animal models to determine the antinociceptive and...

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Main Authors: Sulaiman, Mohd Roslan, Zakaria, Zainul Amiruddin, Kamaruddin, Anita, Teoh, Fei Meng, Israf Ali, Daud Ahmad, Moin, Saidi
Format: Article
Published: Prous Science 2008
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spelling oai:psasir.upm.edu.my:13166 http://psasir.upm.edu.my/id/eprint/13166/ Antinociceptive and antiinflammatory activities of the aqueous extract of Trigonopleura malayana resin in experimental animal models. Sulaiman, Mohd Roslan Zakaria, Zainul Amiruddin Kamaruddin, Anita Teoh, Fei Meng Israf Ali, Daud Ahmad Moin, Saidi Trigonopleura malayana L. (Euphorbiaceae) resin, locally known as Gambir Sarawak, has been used traditionally to alleviate pain associated with insect bites, muscle ache, toothache and minor injuries. The present study was carried out using various animal models to determine the antinociceptive and antiinflammatory activities of the T. malayana resin aqueous extract. Antinociceptive activity was measured using the abdominal constriction, hot plate and formalin tests, while antiinflammatory activity was measured using the carrageenan-induced paw edema test. The extract, obtained after 24 h of soaking the dried resin in distilled water, was prepared in doses of 0.3, 3 and 10 mg/kg and administered subcutaneously 30 min prior to the assays. The mechanism of action was also determined by prechallenging with naloxone (10 mg/kg), a nonselective opioid antagonist. The extract was found to exhibit significant (P < 0.05) and dose-dependent antinociceptive and antiinflammatory activities; naloxone failed to inhibit the former activity. In conclusion, the aqueous extract of T. malayana resin possesses nonopioid antinociceptive and antiinflammatory activities, thus supporting previous claims regarding its traditional use by the Malays to treat various ailments, particularly those related to pain. Prous Science 2008-11 Article PeerReviewed Sulaiman, Mohd Roslan and Zakaria, Zainul Amiruddin and Kamaruddin, Anita and Teoh, Fei Meng and Israf Ali, Daud Ahmad and Moin, Saidi (2008) Antinociceptive and antiinflammatory activities of the aqueous extract of Trigonopleura malayana resin in experimental animal models. Methods and Findings in Experimental and Clinical Pharmacology, 30 (9). pp. 691-696. ISSN 0379-0355; ESSN: 2013-0155 10.1358/mf.2008.30.9.1323494
institution UPM IR
collection UPM IR
description Trigonopleura malayana L. (Euphorbiaceae) resin, locally known as Gambir Sarawak, has been used traditionally to alleviate pain associated with insect bites, muscle ache, toothache and minor injuries. The present study was carried out using various animal models to determine the antinociceptive and antiinflammatory activities of the T. malayana resin aqueous extract. Antinociceptive activity was measured using the abdominal constriction, hot plate and formalin tests, while antiinflammatory activity was measured using the carrageenan-induced paw edema test. The extract, obtained after 24 h of soaking the dried resin in distilled water, was prepared in doses of 0.3, 3 and 10 mg/kg and administered subcutaneously 30 min prior to the assays. The mechanism of action was also determined by prechallenging with naloxone (10 mg/kg), a nonselective opioid antagonist. The extract was found to exhibit significant (P < 0.05) and dose-dependent antinociceptive and antiinflammatory activities; naloxone failed to inhibit the former activity. In conclusion, the aqueous extract of T. malayana resin possesses nonopioid antinociceptive and antiinflammatory activities, thus supporting previous claims regarding its traditional use by the Malays to treat various ailments, particularly those related to pain.
format Article
author Sulaiman, Mohd Roslan
Zakaria, Zainul Amiruddin
Kamaruddin, Anita
Teoh, Fei Meng
Israf Ali, Daud Ahmad
Moin, Saidi
spellingShingle Sulaiman, Mohd Roslan
Zakaria, Zainul Amiruddin
Kamaruddin, Anita
Teoh, Fei Meng
Israf Ali, Daud Ahmad
Moin, Saidi
Antinociceptive and antiinflammatory activities of the aqueous extract of Trigonopleura malayana resin in experimental animal models.
author_facet Sulaiman, Mohd Roslan
Zakaria, Zainul Amiruddin
Kamaruddin, Anita
Teoh, Fei Meng
Israf Ali, Daud Ahmad
Moin, Saidi
author_sort Sulaiman, Mohd Roslan
title Antinociceptive and antiinflammatory activities of the aqueous extract of Trigonopleura malayana resin in experimental animal models.
title_short Antinociceptive and antiinflammatory activities of the aqueous extract of Trigonopleura malayana resin in experimental animal models.
title_full Antinociceptive and antiinflammatory activities of the aqueous extract of Trigonopleura malayana resin in experimental animal models.
title_fullStr Antinociceptive and antiinflammatory activities of the aqueous extract of Trigonopleura malayana resin in experimental animal models.
title_full_unstemmed Antinociceptive and antiinflammatory activities of the aqueous extract of Trigonopleura malayana resin in experimental animal models.
title_sort antinociceptive and antiinflammatory activities of the aqueous extract of trigonopleura malayana resin in experimental animal models.
publisher Prous Science
publishDate 2008
_version_ 1819293682986123264
score 13.4562235

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