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Copper(II) complexes of methylated glycine derivatives: effect of methyl substituent on their DNA binding and nucleolytic property

A set of copper(II) complexes of glycine and methylated glycine derivatives, Cu(aa)2, consisting of C-dimethylglycine, l-alanine, N-dimethylglycine and sarcosine, was investigated for their DNA binding and nucleolytic properties by means of EPR and visible spectroscopy, and electrophoresis. They bin...

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Main Authors:	Seng, Hoi Ling, Tan, Kong Wai, Maah, Mohd Jamil, Tan, Wee Tee, Hamada, Hirokazu, Chikira, Makoto, Ng, Chew Hee
Format:	Article
Published:	Pergamon Press 2009
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id	oai:psasir.upm.edu.my:13796
record_format	eprints
spelling	oai:psasir.upm.edu.my:13796 http://psasir.upm.edu.my/id/eprint/13796/ Copper(II) complexes of methylated glycine derivatives: effect of methyl substituent on their DNA binding and nucleolytic property Seng, Hoi Ling Tan, Kong Wai Maah, Mohd Jamil Tan, Wee Tee Hamada, Hirokazu Chikira, Makoto Ng, Chew Hee A set of copper(II) complexes of glycine and methylated glycine derivatives, Cu(aa)2, consisting of C-dimethylglycine, l-alanine, N-dimethylglycine and sarcosine, was investigated for their DNA binding and nucleolytic properties by means of EPR and visible spectroscopy, and electrophoresis. They bind weakly to DNA with apparent binding constants in the range 1.8–2.9 × 103 M−1 with very similar orientation. No DNA cleavage is observed in the absence of exogenous agents. Copper(II) complexes of N-methylated derivatives bind to DNA more stereo-specifically and less strongly, and their oxidative DNA cleavage is less efficient than those of the corresponding C-methylated derivatives in the presence of hydrogen peroxide (H2O2) alone, or sodium ascorbate (NaHA) alone or tandem H2O2–NaHA. The oxidative DNA cleavage mechanism in the three systems involves a common copper(I) species. Neocuproine can inhibit DNA cleavage by these complexes. Pergamon Press 2009-07-06 Article PeerReviewed Seng, Hoi Ling and Tan, Kong Wai and Maah, Mohd Jamil and Tan, Wee Tee and Hamada, Hirokazu and Chikira, Makoto and Ng, Chew Hee (2009) Copper(II) complexes of methylated glycine derivatives: effect of methyl substituent on their DNA binding and nucleolytic property. Polyhedron, 28 (11). pp. 2219-2227. ISSN 0277-5387; ESSN: 1873-3719 10.1016/j.poly.2009.03.022
institution	UPM IR
collection	UPM IR
description	A set of copper(II) complexes of glycine and methylated glycine derivatives, Cu(aa)2, consisting of C-dimethylglycine, l-alanine, N-dimethylglycine and sarcosine, was investigated for their DNA binding and nucleolytic properties by means of EPR and visible spectroscopy, and electrophoresis. They bind weakly to DNA with apparent binding constants in the range 1.8–2.9 × 103 M−1 with very similar orientation. No DNA cleavage is observed in the absence of exogenous agents. Copper(II) complexes of N-methylated derivatives bind to DNA more stereo-specifically and less strongly, and their oxidative DNA cleavage is less efficient than those of the corresponding C-methylated derivatives in the presence of hydrogen peroxide (H2O2) alone, or sodium ascorbate (NaHA) alone or tandem H2O2–NaHA. The oxidative DNA cleavage mechanism in the three systems involves a common copper(I) species. Neocuproine can inhibit DNA cleavage by these complexes.
format	Article
author	Seng, Hoi Ling Tan, Kong Wai Maah, Mohd Jamil Tan, Wee Tee Hamada, Hirokazu Chikira, Makoto Ng, Chew Hee
spellingShingle	Seng, Hoi Ling Tan, Kong Wai Maah, Mohd Jamil Tan, Wee Tee Hamada, Hirokazu Chikira, Makoto Ng, Chew Hee Copper(II) complexes of methylated glycine derivatives: effect of methyl substituent on their DNA binding and nucleolytic property
author_facet	Seng, Hoi Ling Tan, Kong Wai Maah, Mohd Jamil Tan, Wee Tee Hamada, Hirokazu Chikira, Makoto Ng, Chew Hee
author_sort	Seng, Hoi Ling
title	Copper(II) complexes of methylated glycine derivatives: effect of methyl substituent on their DNA binding and nucleolytic property
title_short	Copper(II) complexes of methylated glycine derivatives: effect of methyl substituent on their DNA binding and nucleolytic property
title_full	Copper(II) complexes of methylated glycine derivatives: effect of methyl substituent on their DNA binding and nucleolytic property
title_fullStr	Copper(II) complexes of methylated glycine derivatives: effect of methyl substituent on their DNA binding and nucleolytic property
title_full_unstemmed	Copper(II) complexes of methylated glycine derivatives: effect of methyl substituent on their DNA binding and nucleolytic property
title_sort	copper(ii) complexes of methylated glycine derivatives: effect of methyl substituent on their dna binding and nucleolytic property
publisher	Pergamon Press
publishDate	2009
_version_	1782718612927152128
score	12.935284

Copper(II) complexes of methylated glycine derivatives: effect of methyl substituent on their DNA binding and nucleolytic property

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