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Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities

A series of 46 curcumin related diarylpentanoidanalogues were synthesized and evaluated for their anti-inflammatory, antioxidant and anti-tyrosinaseactivities. Among these compounds 2, 13 and 33 exhibited potent NO inhibitory effect on IFN-γ/LPS-activated RAW 264.7 cells as compared to l-NAME and cu...

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Main Authors:	Ka-Heng, Lee, Ab. Aziz, Farida Haryani, Ahmad, Syahida, Abas, Faridah, Shaari, Khozirah, Israf Ali, Daud Ahmad, Lajis, Nordin
Format:	Article
Language:	English English
Published:	Elsevier 2009
Subjects:	Anti-inflammatory agents Antioxidants
Online Access:	http://psasir.upm.edu.my/id/eprint/16920/1/Synthesis%20and%20biological%20evaluation%20of%20curcumin.pdf
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id	oai:psasir.upm.edu.my:16920
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spelling	oai:psasir.upm.edu.my:16920 http://psasir.upm.edu.my/id/eprint/16920/ Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities Ka-Heng, Lee Ab. Aziz, Farida Haryani Ahmad, Syahida Abas, Faridah Shaari, Khozirah Israf Ali, Daud Ahmad Lajis, Nordin A series of 46 curcumin related diarylpentanoidanalogues were synthesized and evaluated for their anti-inflammatory, antioxidant and anti-tyrosinaseactivities. Among these compounds 2, 13 and 33 exhibited potent NO inhibitory effect on IFN-γ/LPS-activated RAW 264.7 cells as compared to l-NAME and curcumin. However, these series of diarylpentanoidanalogues were not significantly inhibiting NO scavenging, total radical scavenging and tyrosinase enzyme activities. The results revealed that the biologicalactivity of these diarylpentanoidanalogues is most likely due to their action mainly upon inflammatory mediator, inducible nitric oxide synthase (iNOS). The present results showed that compounds 2, 13 and 33 might serve as a useful starting point for the design of improved anti-inflammatory agents. Elsevier 2009-08 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/16920/1/Synthesis%20and%20biological%20evaluation%20of%20curcumin.pdf Ka-Heng, Lee and Ab. Aziz, Farida Haryani and Ahmad, Syahida and Abas, Faridah and Shaari, Khozirah and Israf Ali, Daud Ahmad and Lajis, Nordin (2009) Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities. European Journal of Medicinal Chemistry, 44 (8). pp. 3195-3200. ISSN 0223-5234 Anti-inflammatory agents Antioxidants 10.1016/j.ejmech.2009.03.020 English
institution	UPM IR
collection	UPM IR
language	English English
topic	Anti-inflammatory agents Antioxidants
spellingShingle	Anti-inflammatory agents Antioxidants Ka-Heng, Lee Ab. Aziz, Farida Haryani Ahmad, Syahida Abas, Faridah Shaari, Khozirah Israf Ali, Daud Ahmad Lajis, Nordin Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities
description	A series of 46 curcumin related diarylpentanoidanalogues were synthesized and evaluated for their anti-inflammatory, antioxidant and anti-tyrosinaseactivities. Among these compounds 2, 13 and 33 exhibited potent NO inhibitory effect on IFN-γ/LPS-activated RAW 264.7 cells as compared to l-NAME and curcumin. However, these series of diarylpentanoidanalogues were not significantly inhibiting NO scavenging, total radical scavenging and tyrosinase enzyme activities. The results revealed that the biologicalactivity of these diarylpentanoidanalogues is most likely due to their action mainly upon inflammatory mediator, inducible nitric oxide synthase (iNOS). The present results showed that compounds 2, 13 and 33 might serve as a useful starting point for the design of improved anti-inflammatory agents.
format	Article
author	Ka-Heng, Lee Ab. Aziz, Farida Haryani Ahmad, Syahida Abas, Faridah Shaari, Khozirah Israf Ali, Daud Ahmad Lajis, Nordin
author_facet	Ka-Heng, Lee Ab. Aziz, Farida Haryani Ahmad, Syahida Abas, Faridah Shaari, Khozirah Israf Ali, Daud Ahmad Lajis, Nordin
author_sort	Ka-Heng, Lee
title	Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities
title_short	Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities
title_full	Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities
title_fullStr	Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities
title_full_unstemmed	Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities
title_sort	synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities
publisher	Elsevier
publishDate	2009
url	http://psasir.upm.edu.my/id/eprint/16920/1/Synthesis%20and%20biological%20evaluation%20of%20curcumin.pdf
_version_	1819294080949026816
score	13.4562235

Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities

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