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Carbon nanomaterials as drug transporter for cancer therapy

There is a vigorous and growing research effort developing carbon nanotubes (CNTs) for medical applications. It is now known that nanocomposites of Single Wall Nanotubes (SWNTs) can be used to deliver anti-cancer drugs to cells. Also, SWNTs are efficient at converting near infrared (NIR) light to he...

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Main Authors: Che Abdullah, Che Azurahanim, Sear, R. P. L.
Format: Conference or Workshop Item
Language:English
Published: UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience 2014
Online Access:http://psasir.upm.edu.my/id/eprint/17482/1/ABSTRACT%20CAC%202014_2%20medic%208.pdf
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spelling oai:psasir.upm.edu.my:17482 http://psasir.upm.edu.my/id/eprint/17482/ Carbon nanomaterials as drug transporter for cancer therapy Che Abdullah, Che Azurahanim Sear, R. P. L. There is a vigorous and growing research effort developing carbon nanotubes (CNTs) for medical applications. It is now known that nanocomposites of Single Wall Nanotubes (SWNTs) can be used to deliver anti-cancer drugs to cells. Also, SWNTs are efficient at converting near infrared (NIR) light to heat, and can do so in a cell, and so cancer cells can be targeted for destruction by NIR radiation, once the cells have taken up SWNTs. SWNTs are highly insoluble in water, but can be functionalized via physical or covalent attachment of solubilizing molecules and drugs of interest. Once this is done, they are readily taken up by cells. We found evidence that our CNT nanocomposites were found to enter cells via endocytosis (the mechanism cells use to take up nutrients); this agrees with earlier work by Dai and coworkers. Herein, we perform systematic study of the internalization, delivery and subcellular localization and possible adverse effects of SWNTs dispersed in culture media and SWNTs wrapped with different fluorescently labelled peptide (FLP-SWNTs) on Chinese hamster ovary (CHO) cells and SWNTs attached with anti-cancer drug on two common cancerous cell lines, human epithelial carcinoma cell line (HeLa) and colorectal cancer cell lines (WiDr). UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience 2014 Conference or Workshop Item PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/17482/1/ABSTRACT%20CAC%202014_2%20medic%208.pdf Che Abdullah, Che Azurahanim and Sear, R. P. L. (2014) Carbon nanomaterials as drug transporter for cancer therapy. In: Scientific Cancer Research Poster Competition in conjunction with Cancer Awareness Carnival 2014, 10 May 2014, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia. .
institution UPM IR
collection UPM IR
language English
description There is a vigorous and growing research effort developing carbon nanotubes (CNTs) for medical applications. It is now known that nanocomposites of Single Wall Nanotubes (SWNTs) can be used to deliver anti-cancer drugs to cells. Also, SWNTs are efficient at converting near infrared (NIR) light to heat, and can do so in a cell, and so cancer cells can be targeted for destruction by NIR radiation, once the cells have taken up SWNTs. SWNTs are highly insoluble in water, but can be functionalized via physical or covalent attachment of solubilizing molecules and drugs of interest. Once this is done, they are readily taken up by cells. We found evidence that our CNT nanocomposites were found to enter cells via endocytosis (the mechanism cells use to take up nutrients); this agrees with earlier work by Dai and coworkers. Herein, we perform systematic study of the internalization, delivery and subcellular localization and possible adverse effects of SWNTs dispersed in culture media and SWNTs wrapped with different fluorescently labelled peptide (FLP-SWNTs) on Chinese hamster ovary (CHO) cells and SWNTs attached with anti-cancer drug on two common cancerous cell lines, human epithelial carcinoma cell line (HeLa) and colorectal cancer cell lines (WiDr).
format Conference or Workshop Item
author Che Abdullah, Che Azurahanim
Sear, R. P. L.
spellingShingle Che Abdullah, Che Azurahanim
Sear, R. P. L.
Carbon nanomaterials as drug transporter for cancer therapy
author_facet Che Abdullah, Che Azurahanim
Sear, R. P. L.
author_sort Che Abdullah, Che Azurahanim
title Carbon nanomaterials as drug transporter for cancer therapy
title_short Carbon nanomaterials as drug transporter for cancer therapy
title_full Carbon nanomaterials as drug transporter for cancer therapy
title_fullStr Carbon nanomaterials as drug transporter for cancer therapy
title_full_unstemmed Carbon nanomaterials as drug transporter for cancer therapy
title_sort carbon nanomaterials as drug transporter for cancer therapy
publisher UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience
publishDate 2014
url http://psasir.upm.edu.my/id/eprint/17482/1/ABSTRACT%20CAC%202014_2%20medic%208.pdf
_version_ 1819294140447326208
score 13.4562235

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