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Peptides that inhibit the propagation of Newcastle disease virus

The invention relates to recombinant phages carrying fusion peptides that bind to Newcastle Disease Virus (NDV). Such phages are useful as diagnostic reagents to replace anti-NDV antibodies because the phages are capable of competing with the latter antibodies for binding sites on the virus. An equi...

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Hauptverfasser: Tan, Wen Siang, Mohd Yusoff, Khatijah, Nathan, Sheila, Ramanujam, Priadarishini
Format: Patent
Veröffentlicht: 2010
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id oai:psasir.upm.edu.my:20443
record_format eprints
spelling oai:psasir.upm.edu.my:20443 http://psasir.upm.edu.my/id/eprint/20443/ Peptides that inhibit the propagation of Newcastle disease virus Tan, Wen Siang Mohd Yusoff, Khatijah Nathan, Sheila Ramanujam, Priadarishini The invention relates to recombinant phages carrying fusion peptides that bind to Newcastle Disease Virus (NDV). Such phages are useful as diagnostic reagents to replace anti-NDV antibodies because the phages are capable of competing with the latter antibodies for binding sites on the virus. An equilibrium binding assay in solution was developed to measure the binding affinity of these recombinant phages with NDV. Synthetic peptides with the sequences CTLTTKLYC, either in linear or cyclic conformations, inhibited the binding of phages bearing the same sequence to NDV. The synthetic peptides also inhibited NDV propagation in embryonated egg medium, therefore they may be used as therapeutic agents to control, to treat and to eradicate Newcastle disease or any other disease related to NDV. A method using embryonated chicken eggs to evaluate the inhibition activities and also to determine the effective amount of a pharmaceutical composition for such inhibition was also developed. 2010-11-30 Patent NonPeerReviewed Tan Wen Siang (2010) Peptides that inhibit the propagation of Newcastle disease virus. UNSPECIFIED.
institution UPM IR
collection UPM IR
description The invention relates to recombinant phages carrying fusion peptides that bind to Newcastle Disease Virus (NDV). Such phages are useful as diagnostic reagents to replace anti-NDV antibodies because the phages are capable of competing with the latter antibodies for binding sites on the virus. An equilibrium binding assay in solution was developed to measure the binding affinity of these recombinant phages with NDV. Synthetic peptides with the sequences CTLTTKLYC, either in linear or cyclic conformations, inhibited the binding of phages bearing the same sequence to NDV. The synthetic peptides also inhibited NDV propagation in embryonated egg medium, therefore they may be used as therapeutic agents to control, to treat and to eradicate Newcastle disease or any other disease related to NDV. A method using embryonated chicken eggs to evaluate the inhibition activities and also to determine the effective amount of a pharmaceutical composition for such inhibition was also developed.
format Patent
author Tan, Wen Siang
Mohd Yusoff, Khatijah
Nathan, Sheila
Ramanujam, Priadarishini
spellingShingle Tan, Wen Siang
Mohd Yusoff, Khatijah
Nathan, Sheila
Ramanujam, Priadarishini
Peptides that inhibit the propagation of Newcastle disease virus
author_facet Tan, Wen Siang
Mohd Yusoff, Khatijah
Nathan, Sheila
Ramanujam, Priadarishini
author_sort Tan, Wen Siang
title Peptides that inhibit the propagation of Newcastle disease virus
title_short Peptides that inhibit the propagation of Newcastle disease virus
title_full Peptides that inhibit the propagation of Newcastle disease virus
title_fullStr Peptides that inhibit the propagation of Newcastle disease virus
title_full_unstemmed Peptides that inhibit the propagation of Newcastle disease virus
title_sort peptides that inhibit the propagation of newcastle disease virus
publishDate 2010
_version_ 1819294392845860864
score 13.4562235

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