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Bioactive compounds, antioxidant, xanthine oxidase inhibitory, tyrosinase inhibitory and anti-inflammatory activities of selected agro-industrial by-products

Evaluation of abundantly available agro-industrial by-products for their bioactive compounds and biological activities is beneficial in particular for the food and pharmaceutical industries. In this study, rapeseed meal, cottonseed meal and soybean meal were investigated for the presence of bioactiv...

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Main Authors: Oskoueian, Ehsan, Abdullah, Norhani, Hendra, Rudi, Karimi, Ehsan
Format: Article
Language:English
Published: Multidisciplinary Digital Publishing Institute 2011
Online Access:http://psasir.upm.edu.my/id/eprint/22334/1/Bioactive%20compounds%2C%20antioxidant%2C%20xanthine%20oxidase%20inhibitory.pdf
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spelling oai:psasir.upm.edu.my:22334 http://psasir.upm.edu.my/id/eprint/22334/ Bioactive compounds, antioxidant, xanthine oxidase inhibitory, tyrosinase inhibitory and anti-inflammatory activities of selected agro-industrial by-products Oskoueian, Ehsan Abdullah, Norhani Hendra, Rudi Karimi, Ehsan Evaluation of abundantly available agro-industrial by-products for their bioactive compounds and biological activities is beneficial in particular for the food and pharmaceutical industries. In this study, rapeseed meal, cottonseed meal and soybean meal were investigated for the presence of bioactive compounds and antioxidant, anti-inflammatory, xanthine oxidase and tyrosinase inhibitory activities. Methanolic extracts of rapeseed meal showed significantly (P < 0.01) higher phenolics and flavonoids contents; and significantly (P < 0.01) higher DPPH and nitric oxide free radical scavenging activities when compared to that of cottonseed meal and soybean meal extracts. Ferric thiocyanate and thiobarbituric acid tests results showed rapeseed meal with the highest antioxidant activity (P < 0.01) followed by BHT, cotton seed meal and soybean meal. Rapeseed meal extract in xanthine oxidase and tyrosinase inhibitory assays showed the lowest IC50 values followed by cottonseed and soybean meals. Anti-inflammatory assay using IFN-γ/LPS stimulated RAW 264.7 cells indicated rapeseed meal is a potent source of anti-inflammatory agent. Correlation analysis showed that phenolics and flavonoids were highly correlated to both antioxidant and anti-inflammatory activities. Rapeseed meal was found to be promising as a natural source of bioactive compounds with high antioxidant, anti-inflammatory, xanthine oxidase and tyrosinase inhibitory activities in contrast to cotton and soybean meals. Multidisciplinary Digital Publishing Institute 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/22334/1/Bioactive%20compounds%2C%20antioxidant%2C%20xanthine%20oxidase%20inhibitory.pdf Oskoueian, Ehsan and Abdullah, Norhani and Hendra, Rudi and Karimi, Ehsan (2011) Bioactive compounds, antioxidant, xanthine oxidase inhibitory, tyrosinase inhibitory and anti-inflammatory activities of selected agro-industrial by-products. International Journal of Molecular Sciences, 12 (12). pp. 8610-8625. ISSN 1661-6596; ESSN: 1422-0067 http://www.mdpi.com/1422-0067/12/12/8610 10.3390/ijms12128610
institution UPM IR
collection UPM IR
language English
description Evaluation of abundantly available agro-industrial by-products for their bioactive compounds and biological activities is beneficial in particular for the food and pharmaceutical industries. In this study, rapeseed meal, cottonseed meal and soybean meal were investigated for the presence of bioactive compounds and antioxidant, anti-inflammatory, xanthine oxidase and tyrosinase inhibitory activities. Methanolic extracts of rapeseed meal showed significantly (P < 0.01) higher phenolics and flavonoids contents; and significantly (P < 0.01) higher DPPH and nitric oxide free radical scavenging activities when compared to that of cottonseed meal and soybean meal extracts. Ferric thiocyanate and thiobarbituric acid tests results showed rapeseed meal with the highest antioxidant activity (P < 0.01) followed by BHT, cotton seed meal and soybean meal. Rapeseed meal extract in xanthine oxidase and tyrosinase inhibitory assays showed the lowest IC50 values followed by cottonseed and soybean meals. Anti-inflammatory assay using IFN-γ/LPS stimulated RAW 264.7 cells indicated rapeseed meal is a potent source of anti-inflammatory agent. Correlation analysis showed that phenolics and flavonoids were highly correlated to both antioxidant and anti-inflammatory activities. Rapeseed meal was found to be promising as a natural source of bioactive compounds with high antioxidant, anti-inflammatory, xanthine oxidase and tyrosinase inhibitory activities in contrast to cotton and soybean meals.
format Article
author Oskoueian, Ehsan
Abdullah, Norhani
Hendra, Rudi
Karimi, Ehsan
spellingShingle Oskoueian, Ehsan
Abdullah, Norhani
Hendra, Rudi
Karimi, Ehsan
Bioactive compounds, antioxidant, xanthine oxidase inhibitory, tyrosinase inhibitory and anti-inflammatory activities of selected agro-industrial by-products
author_facet Oskoueian, Ehsan
Abdullah, Norhani
Hendra, Rudi
Karimi, Ehsan
author_sort Oskoueian, Ehsan
title Bioactive compounds, antioxidant, xanthine oxidase inhibitory, tyrosinase inhibitory and anti-inflammatory activities of selected agro-industrial by-products
title_short Bioactive compounds, antioxidant, xanthine oxidase inhibitory, tyrosinase inhibitory and anti-inflammatory activities of selected agro-industrial by-products
title_full Bioactive compounds, antioxidant, xanthine oxidase inhibitory, tyrosinase inhibitory and anti-inflammatory activities of selected agro-industrial by-products
title_fullStr Bioactive compounds, antioxidant, xanthine oxidase inhibitory, tyrosinase inhibitory and anti-inflammatory activities of selected agro-industrial by-products
title_full_unstemmed Bioactive compounds, antioxidant, xanthine oxidase inhibitory, tyrosinase inhibitory and anti-inflammatory activities of selected agro-industrial by-products
title_sort bioactive compounds, antioxidant, xanthine oxidase inhibitory, tyrosinase inhibitory and anti-inflammatory activities of selected agro-industrial by-products
publisher Multidisciplinary Digital Publishing Institute
publishDate 2011
url http://psasir.upm.edu.my/id/eprint/22334/1/Bioactive%20compounds%2C%20antioxidant%2C%20xanthine%20oxidase%20inhibitory.pdf
_version_ 1819294558708563968
score 13.4562235

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