Potential role of JAK-STAT signaling pathway in the neurogenic-to-gliogenic shift in down syndrome brain

Trisomy of human chromosome 21 in Down syndrome (DS) leads to several phenotypes, such as mild-to-severe intellectual disability, hypotonia, and craniofacial dysmorphisms. These are fundamental hallmarks of the disorder that affect the quality of life of most individuals with DS. Proper brain develo...

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Bibliographic Details
Main Authors: Lee, Han Chung, Tan, Kai Leng, Cheah, Pike See, Ling, King Hwa
Format: Article
Published: Hindawi Publishing Corporation 2016
Online Access:http://psasir.upm.edu.my/id/eprint/23186/1/23186.pdf