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Association between dietary folate intake and blood status of folate and homocysteine in Malaysian adults.

Folate is of prime interest among investigators in nutrition due to its multiple roles in maintaining health, especially in preventing neural tube defects and reducing the risk of cardiovascular diseases. We investigated the effect of dietary folate intake on blood folate, vitamin B(12), vitamin B(6...

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Main Authors: Chew, Siew Choo, Khor, Geok Lin, Loh, Su Peng
Format: Article
Language:English
English
Published: Center for Academic Publications Japan 2011
Online Access:http://psasir.upm.edu.my/id/eprint/24475/1/Association%20between%20dietary%20folate%20intake%20and%20blood%20status%20of%20folate%20and%20homocysteine%20in%20Malaysian%20adults.pdf
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spelling oai:psasir.upm.edu.my:24475 http://psasir.upm.edu.my/id/eprint/24475/ Association between dietary folate intake and blood status of folate and homocysteine in Malaysian adults. Chew, Siew Choo Khor, Geok Lin Loh, Su Peng Folate is of prime interest among investigators in nutrition due to its multiple roles in maintaining health, especially in preventing neural tube defects and reducing the risk of cardiovascular diseases. We investigated the effect of dietary folate intake on blood folate, vitamin B(12), vitamin B(6), and homocysteine status. One hundred subjects consisting of Chinese and Malay subjects volunteered to participate in this cross-sectional study. Dietary folate intake was assessed by 24-h dietary recall and a food-frequency questionnaire (FFQ). Serum and red blood cell folate were analyzed using a microbiological assay, while serum vitamin B(12) was determined by electrochemiluminescence immunoassay (ECLIA), and high-performance liquid chromatography (HPLC) was used for the determination of serum vitamin B(6) and homocysteine. The mean folate intake, serum folate, RBC folate, serum vitamin B(12), and B(6), were higher in female subjects, with the exception of serum homocysteine. The Chinese tended to have higher folate intake, serum folate, RBC folate, and vitamin B(12). A positive association was found between folate intake and serum folate while a negative association was found between folate intake and serum homocysteine. Stepwise linear regression of serum folate showed a significant positive coefficient for folate intake whilst a significant negative coefficient was found for serum homocysteine when controlling for age, gender, and ethnicity. In conclusion, high dietary folate intake helps to increase serum folate and to lower the homocysteine levels. Center for Academic Publications Japan 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24475/1/Association%20between%20dietary%20folate%20intake%20and%20blood%20status%20of%20folate%20and%20homocysteine%20in%20Malaysian%20adults.pdf Chew, Siew Choo and Khor, Geok Lin and Loh, Su Peng (2011) Association between dietary folate intake and blood status of folate and homocysteine in Malaysian adults. Journal of Nutritional Science and Vitaminology, 57 (2). pp. 150-155. ISSN 0301-4800; ESSN: 1881-7742 English
institution UPM IR
collection UPM IR
language English
English
description Folate is of prime interest among investigators in nutrition due to its multiple roles in maintaining health, especially in preventing neural tube defects and reducing the risk of cardiovascular diseases. We investigated the effect of dietary folate intake on blood folate, vitamin B(12), vitamin B(6), and homocysteine status. One hundred subjects consisting of Chinese and Malay subjects volunteered to participate in this cross-sectional study. Dietary folate intake was assessed by 24-h dietary recall and a food-frequency questionnaire (FFQ). Serum and red blood cell folate were analyzed using a microbiological assay, while serum vitamin B(12) was determined by electrochemiluminescence immunoassay (ECLIA), and high-performance liquid chromatography (HPLC) was used for the determination of serum vitamin B(6) and homocysteine. The mean folate intake, serum folate, RBC folate, serum vitamin B(12), and B(6), were higher in female subjects, with the exception of serum homocysteine. The Chinese tended to have higher folate intake, serum folate, RBC folate, and vitamin B(12). A positive association was found between folate intake and serum folate while a negative association was found between folate intake and serum homocysteine. Stepwise linear regression of serum folate showed a significant positive coefficient for folate intake whilst a significant negative coefficient was found for serum homocysteine when controlling for age, gender, and ethnicity. In conclusion, high dietary folate intake helps to increase serum folate and to lower the homocysteine levels.
format Article
author Chew, Siew Choo
Khor, Geok Lin
Loh, Su Peng
spellingShingle Chew, Siew Choo
Khor, Geok Lin
Loh, Su Peng
Association between dietary folate intake and blood status of folate and homocysteine in Malaysian adults.
author_facet Chew, Siew Choo
Khor, Geok Lin
Loh, Su Peng
author_sort Chew, Siew Choo
title Association between dietary folate intake and blood status of folate and homocysteine in Malaysian adults.
title_short Association between dietary folate intake and blood status of folate and homocysteine in Malaysian adults.
title_full Association between dietary folate intake and blood status of folate and homocysteine in Malaysian adults.
title_fullStr Association between dietary folate intake and blood status of folate and homocysteine in Malaysian adults.
title_full_unstemmed Association between dietary folate intake and blood status of folate and homocysteine in Malaysian adults.
title_sort association between dietary folate intake and blood status of folate and homocysteine in malaysian adults.
publisher Center for Academic Publications Japan
publishDate 2011
url http://psasir.upm.edu.my/id/eprint/24475/1/Association%20between%20dietary%20folate%20intake%20and%20blood%20status%20of%20folate%20and%20homocysteine%20in%20Malaysian%20adults.pdf
_version_ 1782719989586853888
score 12.933938

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