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Histopathological features of peripheral T-cell lymphoma in Sprague Dawley rats induced with N-methyl-N-nitrosourea

This study described the histopathological features of peripheral T-cell lymphoma in male Sprague Dawley rats following intraperitoneal (i.p.) injections of N-methyl-N-nitrosourea (MNU) at a dose of 60 mg/kg body weight per injection, administered twice weekly for 2 consecutive weeks, and followed...

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Main Authors: Al-Salih, Hutheyfa A. H., Hamzah, Hazilawati, Shaari, Mohd Rosly, Sabri, Jasni, Mohamed Mustapha, Noordin, Sithambaram, Shanmugavelu
格式: Article
语言:English
出版: Universiti Putra Malaysia Press 2011
在线阅读:http://psasir.upm.edu.my/id/eprint/25342/1/21%20Pg%20351-361.pdf
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spelling oai:psasir.upm.edu.my:25342 http://psasir.upm.edu.my/id/eprint/25342/ Histopathological features of peripheral T-cell lymphoma in Sprague Dawley rats induced with N-methyl-N-nitrosourea Al-Salih, Hutheyfa A. H. Hamzah, Hazilawati Shaari, Mohd Rosly Sabri, Jasni Mohamed Mustapha, Noordin Sithambaram, Shanmugavelu This study described the histopathological features of peripheral T-cell lymphoma in male Sprague Dawley rats following intraperitoneal (i.p.) injections of N-methyl-N-nitrosourea (MNU) at a dose of 60 mg/kg body weight per injection, administered twice weekly for 2 consecutive weeks, and followed by a five-month’s observation period. Control rats were injected with normal saline, i.p. All the rats treated with MNU had enlargement of lymph nodes, with 30% had hepatosplenomegaly and 7% had enlarged kidneys at necropsy. Malignant lymphoma was observed in the lymph nodes, spleen, liver, lung, heart, and kidneys. The neoplastic cells were characterised as undifferentiated, and small to large size with bizarre pleomorphic nuclei. The severity was further described as mild, moderate and severe, based on the diffuseness of the lesions. Nonetheless, similar lesions were not observed in the thymus of the rats. Immunohistochemistry staining of the organs was positive for CD3 antibody, which is consistent with T-cell lymphoma. Universiti Putra Malaysia Press 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/25342/1/21%20Pg%20351-361.pdf Al-Salih, Hutheyfa A. H. and Hamzah, Hazilawati and Shaari, Mohd Rosly and Sabri, Jasni and Mohamed Mustapha, Noordin and Sithambaram, Shanmugavelu (2011) Histopathological features of peripheral T-cell lymphoma in Sprague Dawley rats induced with N-methyl-N-nitrosourea. Pertanika Journal of Tropical Agricultural Science, 34 (2). pp. 351-361. ISSN 1511-3701; ESSN: 2231-8542 http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JTAS%20Vol.%2034%20(2)%20Aug.%202011/21%20Pg%20351-361.pdf
institution UPM IR
collection UPM IR
language English
description This study described the histopathological features of peripheral T-cell lymphoma in male Sprague Dawley rats following intraperitoneal (i.p.) injections of N-methyl-N-nitrosourea (MNU) at a dose of 60 mg/kg body weight per injection, administered twice weekly for 2 consecutive weeks, and followed by a five-month’s observation period. Control rats were injected with normal saline, i.p. All the rats treated with MNU had enlargement of lymph nodes, with 30% had hepatosplenomegaly and 7% had enlarged kidneys at necropsy. Malignant lymphoma was observed in the lymph nodes, spleen, liver, lung, heart, and kidneys. The neoplastic cells were characterised as undifferentiated, and small to large size with bizarre pleomorphic nuclei. The severity was further described as mild, moderate and severe, based on the diffuseness of the lesions. Nonetheless, similar lesions were not observed in the thymus of the rats. Immunohistochemistry staining of the organs was positive for CD3 antibody, which is consistent with T-cell lymphoma.
format Article
author Al-Salih, Hutheyfa A. H.
Hamzah, Hazilawati
Shaari, Mohd Rosly
Sabri, Jasni
Mohamed Mustapha, Noordin
Sithambaram, Shanmugavelu
spellingShingle Al-Salih, Hutheyfa A. H.
Hamzah, Hazilawati
Shaari, Mohd Rosly
Sabri, Jasni
Mohamed Mustapha, Noordin
Sithambaram, Shanmugavelu
Histopathological features of peripheral T-cell lymphoma in Sprague Dawley rats induced with N-methyl-N-nitrosourea
author_facet Al-Salih, Hutheyfa A. H.
Hamzah, Hazilawati
Shaari, Mohd Rosly
Sabri, Jasni
Mohamed Mustapha, Noordin
Sithambaram, Shanmugavelu
author_sort Al-Salih, Hutheyfa A. H.
title Histopathological features of peripheral T-cell lymphoma in Sprague Dawley rats induced with N-methyl-N-nitrosourea
title_short Histopathological features of peripheral T-cell lymphoma in Sprague Dawley rats induced with N-methyl-N-nitrosourea
title_full Histopathological features of peripheral T-cell lymphoma in Sprague Dawley rats induced with N-methyl-N-nitrosourea
title_fullStr Histopathological features of peripheral T-cell lymphoma in Sprague Dawley rats induced with N-methyl-N-nitrosourea
title_full_unstemmed Histopathological features of peripheral T-cell lymphoma in Sprague Dawley rats induced with N-methyl-N-nitrosourea
title_sort histopathological features of peripheral t-cell lymphoma in sprague dawley rats induced with n-methyl-n-nitrosourea
publisher Universiti Putra Malaysia Press
publishDate 2011
url http://psasir.upm.edu.my/id/eprint/25342/1/21%20Pg%20351-361.pdf
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score 13.4562235

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