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Antipyretic effect of crude methanolic extract of Mytragyna speciosa in mice.

Mitragyna speciosa is a species of tropical indigenous plant that can be found mainly in Southeast Asia. This study aims to ascertain the existence of antipyretic properties of the crude methanolic extract of Mitragynaspeciosa, and determine its effective dose against Brewer's yeast-induced pyr...

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Main Authors: Salleh, Annas, Abdul Kadir, Arifah, Shaik Mossadeq, Wan Mastura
Format: Conference or Workshop Item
Language:English
English
Published: 2011
Online Access:http://psasir.upm.edu.my/id/eprint/26521/1/Proceedings%201.pdf
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spelling oai:psasir.upm.edu.my:26521 http://psasir.upm.edu.my/id/eprint/26521/ Antipyretic effect of crude methanolic extract of Mytragyna speciosa in mice. Salleh, Annas Abdul Kadir, Arifah Shaik Mossadeq, Wan Mastura Mitragyna speciosa is a species of tropical indigenous plant that can be found mainly in Southeast Asia. This study aims to ascertain the existence of antipyretic properties of the crude methanolic extract of Mitragynaspeciosa, and determine its effective dose against Brewer's yeast-induced pyrexia in mice. Thirty BALB/c mice were randomly divided into three treatment groups and two control groups. Pyrexia was induced by subcutaneous injection of 30% Brewer's yeast. Rectal temperature was recorded before and 18 h after induction of pyrexia every 30 min ofr 5 h. All groups treated with the crude methanolic extracts of Mitragynaspeciosa (50 mg/kg), 200 mg/kg were observed to produce signifivantreduction of rectal temperture as compared to the negative control group at different times. Ketoprofen at the dosage of 1 mg/kg coused significant (p<0.001) inhibition of fever from 0.5 to 5.0 h after treatment. In conclution, the crude methanolic extract of Mitragyna speciosa possessed dose-dependent antipyretic properties in mice. The antipyretic effective dose of the crude methanolic extract of Mitragyna speciosa was 100 mg/kg. 2011-01-11 Conference or Workshop Item PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/26521/1/Proceedings%201.pdf Salleh, Annas and Abdul Kadir, Arifah and Shaik Mossadeq, Wan Mastura (2011) Antipyretic effect of crude methanolic extract of Mytragyna speciosa in mice. In: 6th Proceedings of the Seminar on Veterinary Sciences, 11-14 Jan. 2011, Kuala Lumpur . (pp. 1-6). English
institution UPM IR
collection UPM IR
language English
English
description Mitragyna speciosa is a species of tropical indigenous plant that can be found mainly in Southeast Asia. This study aims to ascertain the existence of antipyretic properties of the crude methanolic extract of Mitragynaspeciosa, and determine its effective dose against Brewer's yeast-induced pyrexia in mice. Thirty BALB/c mice were randomly divided into three treatment groups and two control groups. Pyrexia was induced by subcutaneous injection of 30% Brewer's yeast. Rectal temperature was recorded before and 18 h after induction of pyrexia every 30 min ofr 5 h. All groups treated with the crude methanolic extracts of Mitragynaspeciosa (50 mg/kg), 200 mg/kg were observed to produce signifivantreduction of rectal temperture as compared to the negative control group at different times. Ketoprofen at the dosage of 1 mg/kg coused significant (p<0.001) inhibition of fever from 0.5 to 5.0 h after treatment. In conclution, the crude methanolic extract of Mitragyna speciosa possessed dose-dependent antipyretic properties in mice. The antipyretic effective dose of the crude methanolic extract of Mitragyna speciosa was 100 mg/kg.
format Conference or Workshop Item
author Salleh, Annas
Abdul Kadir, Arifah
Shaik Mossadeq, Wan Mastura
spellingShingle Salleh, Annas
Abdul Kadir, Arifah
Shaik Mossadeq, Wan Mastura
Antipyretic effect of crude methanolic extract of Mytragyna speciosa in mice.
author_facet Salleh, Annas
Abdul Kadir, Arifah
Shaik Mossadeq, Wan Mastura
author_sort Salleh, Annas
title Antipyretic effect of crude methanolic extract of Mytragyna speciosa in mice.
title_short Antipyretic effect of crude methanolic extract of Mytragyna speciosa in mice.
title_full Antipyretic effect of crude methanolic extract of Mytragyna speciosa in mice.
title_fullStr Antipyretic effect of crude methanolic extract of Mytragyna speciosa in mice.
title_full_unstemmed Antipyretic effect of crude methanolic extract of Mytragyna speciosa in mice.
title_sort antipyretic effect of crude methanolic extract of mytragyna speciosa in mice.
publishDate 2011
url http://psasir.upm.edu.my/id/eprint/26521/1/Proceedings%201.pdf
_version_ 1819294952549515264
score 13.4562235

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