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Sub-acute oral administration of Cymbopogon citratus stem infusion and its effects on blood biochemical parameters, body and organ weights in rats

A study was conducted to determine the effects of lemon grass stem infusion (Cymbopogon citratus) in female Sprague-Dawley rats. The objective of the study was to develop a basic guideline for safe use of lemon grass stem infusion. A total of 18 female rats were fed with 13 and 130 mg/kg body weig...

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Hoofdauteurs: Hosni, Hanisa, Hassan, Hadijah, Abdullah, Rasedee, Salimin, Ahmad Tarmizi
Formaat: Artikel
Taal:English
Gepubliceerd in: Malaysian Agricultural Research and Development Institute (MARDI) 2011
Online toegang:http://psasir.upm.edu.my/id/eprint/27076/1/Sub.pdf
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spelling oai:psasir.upm.edu.my:27076 http://psasir.upm.edu.my/id/eprint/27076/ Sub-acute oral administration of Cymbopogon citratus stem infusion and its effects on blood biochemical parameters, body and organ weights in rats Hosni, Hanisa Hassan, Hadijah Abdullah, Rasedee Salimin, Ahmad Tarmizi A study was conducted to determine the effects of lemon grass stem infusion (Cymbopogon citratus) in female Sprague-Dawley rats. The objective of the study was to develop a basic guideline for safe use of lemon grass stem infusion. A total of 18 female rats were fed with 13 and 130 mg/kg body weight (BW) of the infusion for 28 days. Control rats only received distilled water. Blood samples were collected to assess renal and liver functions. Repeated administration of lemon grass stem infusion to rats did not produce any significant change in their blood lipid profiles [cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and triglycerides], liver function parameters [aspartate transaminase (AST), alanine transaminase (ALT) and gamma-glutamyl transferase (GGT)], renal function parameters (creatinine, urea and uric acid), total protein and glucose concentrations. The intake of the infusion also did not show hepatotoxic and nephrotoxic signs on rats. The weight of rats receiving the dose at 130 mg/kg BW (which is equivalent to 10 times of normal human consumption), was almost similar to the control group. The rats survived the treatment without showing any ill-effect. Based on this study, lemon grass stem infusion was not toxic even at 10 times higher than normal human consumption. Malaysian Agricultural Research and Development Institute (MARDI) 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/27076/1/Sub.pdf Hosni, Hanisa and Hassan, Hadijah and Abdullah, Rasedee and Salimin, Ahmad Tarmizi (2011) Sub-acute oral administration of Cymbopogon citratus stem infusion and its effects on blood biochemical parameters, body and organ weights in rats. Journal of Tropical Agriculture and Food Science, 39 (1). pp. 1-7. ISSN 1394-9829; ESSN: 2289-9650 http://ejtafs.mardi.gov.my/index.php/publication/issues/archive/25-2011/volume-39-no1/33-390107
institution UPM IR
collection UPM IR
language English
description A study was conducted to determine the effects of lemon grass stem infusion (Cymbopogon citratus) in female Sprague-Dawley rats. The objective of the study was to develop a basic guideline for safe use of lemon grass stem infusion. A total of 18 female rats were fed with 13 and 130 mg/kg body weight (BW) of the infusion for 28 days. Control rats only received distilled water. Blood samples were collected to assess renal and liver functions. Repeated administration of lemon grass stem infusion to rats did not produce any significant change in their blood lipid profiles [cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and triglycerides], liver function parameters [aspartate transaminase (AST), alanine transaminase (ALT) and gamma-glutamyl transferase (GGT)], renal function parameters (creatinine, urea and uric acid), total protein and glucose concentrations. The intake of the infusion also did not show hepatotoxic and nephrotoxic signs on rats. The weight of rats receiving the dose at 130 mg/kg BW (which is equivalent to 10 times of normal human consumption), was almost similar to the control group. The rats survived the treatment without showing any ill-effect. Based on this study, lemon grass stem infusion was not toxic even at 10 times higher than normal human consumption.
format Article
author Hosni, Hanisa
Hassan, Hadijah
Abdullah, Rasedee
Salimin, Ahmad Tarmizi
spellingShingle Hosni, Hanisa
Hassan, Hadijah
Abdullah, Rasedee
Salimin, Ahmad Tarmizi
Sub-acute oral administration of Cymbopogon citratus stem infusion and its effects on blood biochemical parameters, body and organ weights in rats
author_facet Hosni, Hanisa
Hassan, Hadijah
Abdullah, Rasedee
Salimin, Ahmad Tarmizi
author_sort Hosni, Hanisa
title Sub-acute oral administration of Cymbopogon citratus stem infusion and its effects on blood biochemical parameters, body and organ weights in rats
title_short Sub-acute oral administration of Cymbopogon citratus stem infusion and its effects on blood biochemical parameters, body and organ weights in rats
title_full Sub-acute oral administration of Cymbopogon citratus stem infusion and its effects on blood biochemical parameters, body and organ weights in rats
title_fullStr Sub-acute oral administration of Cymbopogon citratus stem infusion and its effects on blood biochemical parameters, body and organ weights in rats
title_full_unstemmed Sub-acute oral administration of Cymbopogon citratus stem infusion and its effects on blood biochemical parameters, body and organ weights in rats
title_sort sub-acute oral administration of cymbopogon citratus stem infusion and its effects on blood biochemical parameters, body and organ weights in rats
publisher Malaysian Agricultural Research and Development Institute (MARDI)
publishDate 2011
url http://psasir.upm.edu.my/id/eprint/27076/1/Sub.pdf
_version_ 1819295001984630784
score 13.4562235

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