Cover Image

Influence of mast cells in drug-induced gingival overgrowth

Mast cells (MCs) are multifunctional effector cells that were originally thought to be involved in allergic disorders. Now it is known that they contain an array of mediators with a multitude of effects on many other cells. MCs have become a recent concern in drug-induced gingival overgrowth (DIGO),...

Full description

Saved in:
Bibliographic Details
Main Authors: Subramani, Tamilselvan, Rathnavelu, Vidhya, Yeap, Swee Keong, Mohammed Alitheen, Noorjahan Banu
Format: Article
Language:English
Published: Hindawi Publishing Corporation 2013
Online Access:http://psasir.upm.edu.my/id/eprint/28012/1/275172.pdf
Tags: Add Tag
No Tags, Be the first to tag this record!
id oai:psasir.upm.edu.my:28012
record_format eprints
spelling oai:psasir.upm.edu.my:28012 http://psasir.upm.edu.my/id/eprint/28012/ Influence of mast cells in drug-induced gingival overgrowth Subramani, Tamilselvan Rathnavelu, Vidhya Yeap, Swee Keong Mohammed Alitheen, Noorjahan Banu Mast cells (MCs) are multifunctional effector cells that were originally thought to be involved in allergic disorders. Now it is known that they contain an array of mediators with a multitude of effects on many other cells. MCs have become a recent concern in drug-induced gingival overgrowth (DIGO), an unwanted outcome of systemic medication. Most of the studies have confirmed the significant presence of inflammation as a prerequisite for the overgrowth to occur. The inflammatory changes within the gingival tissue appear to influence the interaction between the inducing drug and the fibroblast activity. The development of antibodies to MC-specific enzymes, tryptase and chymase, has facilitated the study of mast cells in DIGO. Many immunohistochemical studies involving MCs have been conducted; as a result, DIGO tissues are found to have increased the number of MCs in the gingiva, especially in the area of fibrosis. At the cellular level, gingival fibrogenesis is initiated by several mediators which induce the recruitment of a large number of inflammatory cells, including MCs. The purpose of this paper is to access the roles played by MCs in gingival overgrowth to hypothesize a relationship between these highly specialized cells in the pathogenesis of DIGO. Hindawi Publishing Corporation 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/28012/1/275172.pdf Subramani, Tamilselvan and Rathnavelu, Vidhya and Yeap, Swee Keong and Mohammed Alitheen, Noorjahan Banu (2013) Influence of mast cells in drug-induced gingival overgrowth. Mediators of Inflammation, 2013. art. no. 275172. pp. 1-8. ISSN 0962-9351; ESSN: 1466-1861 http://www.hindawi.com/journals/mi/2013/275172/abs/ 10.1155/2013/275172
institution UPM IR
collection UPM IR
language English
description Mast cells (MCs) are multifunctional effector cells that were originally thought to be involved in allergic disorders. Now it is known that they contain an array of mediators with a multitude of effects on many other cells. MCs have become a recent concern in drug-induced gingival overgrowth (DIGO), an unwanted outcome of systemic medication. Most of the studies have confirmed the significant presence of inflammation as a prerequisite for the overgrowth to occur. The inflammatory changes within the gingival tissue appear to influence the interaction between the inducing drug and the fibroblast activity. The development of antibodies to MC-specific enzymes, tryptase and chymase, has facilitated the study of mast cells in DIGO. Many immunohistochemical studies involving MCs have been conducted; as a result, DIGO tissues are found to have increased the number of MCs in the gingiva, especially in the area of fibrosis. At the cellular level, gingival fibrogenesis is initiated by several mediators which induce the recruitment of a large number of inflammatory cells, including MCs. The purpose of this paper is to access the roles played by MCs in gingival overgrowth to hypothesize a relationship between these highly specialized cells in the pathogenesis of DIGO.
format Article
author Subramani, Tamilselvan
Rathnavelu, Vidhya
Yeap, Swee Keong
Mohammed Alitheen, Noorjahan Banu
spellingShingle Subramani, Tamilselvan
Rathnavelu, Vidhya
Yeap, Swee Keong
Mohammed Alitheen, Noorjahan Banu
Influence of mast cells in drug-induced gingival overgrowth
author_facet Subramani, Tamilselvan
Rathnavelu, Vidhya
Yeap, Swee Keong
Mohammed Alitheen, Noorjahan Banu
author_sort Subramani, Tamilselvan
title Influence of mast cells in drug-induced gingival overgrowth
title_short Influence of mast cells in drug-induced gingival overgrowth
title_full Influence of mast cells in drug-induced gingival overgrowth
title_fullStr Influence of mast cells in drug-induced gingival overgrowth
title_full_unstemmed Influence of mast cells in drug-induced gingival overgrowth
title_sort influence of mast cells in drug-induced gingival overgrowth
publisher Hindawi Publishing Corporation
publishDate 2013
url http://psasir.upm.edu.my/id/eprint/28012/1/275172.pdf
_version_ 1782720323561455616
score 12.935284

Similar Items