Cover Image

Total synthesis, cytotoxic effects of damnacanthal, nordamnacanthal and related anthraquinone analogues

Naturally occurring anthraquinones, damnacanthal (1) and nordamnacanthal (2) were synthesized with modified reaction steps and investigated for their cytotoxicity against the MCF-7 and K-562 cancer cell lines, respectively. Intermediate analogues 2-bromomethyl-1,3-dimethoxyanthraquinone (5, IC 50 =...

Full description

Saved in:

Bibliographic Details
Main Authors:	Akhtar, Muhammad Nadeem, Zareen, Seema, Yeap, Swee Keong, Ho, Wan Yong, Lo, Kong Mun, Hasan, Aurangzeb, Mohammed Alitheen, Noorjahan Banu
Format:	Article
Language:	English
Published:	MDPI 2013
Online Access:	http://psasir.upm.edu.my/id/eprint/28053/1/molecules-18-10042%20%281%29.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Cytotoxic properties of anthraquinones (nordamnacanthal and damnacanthal) from roots of Morinda elliptica
by: Saiful Yazan, Latifah
Published: (2003)

Cytotoxic Properties of Anthraquinones (Nordamnacanthal and Damnacanthal) from Roots of Morinda Elliptica
by: Saiful Yazan, Latifah
Published: (2003)

Cytotoxic properties of anthraquinones (nordamnacanthal and damnacanthal) from roots of Morinda elliptica /
by: Latifah Saiful Yazan.

Cytotoxicity and immunomodulatory effects of damnacanthal and nordamnacanthal isolated from roots of morinda elliptica.
by: Mohamed Alitheen, Noorjahan Banu, et al.
Published: (2010)

Cytotoxic effect of damnacanthal, nordamnacanthal, zerumbone and betulinic acid isolated from Malaysian plant sources
by: Mohamed Alitheen, Noorjahan Banu, et al.
Published: (2010)

Damnacanthal: a promising compound as a medicinal anthraquinone
by: Abu, Nadiah, et al.
Published: (2014)

Cytotoxicity and immunomodulatory effects of damnacanthal and nordamnacanthal isolated from roots of Morinda elliptica
by: Yeap, S. K., et al.
Published: (2020)

Induction of apoptosis in CEM-SS cells by anthraquinones (nordamnacanthal and damnacanthal) from the roots of Morinda elliptica : evidence by DNA fragmentation
by: Latifah Saiful Yazan, et al.
Published: (2014)

Nordamnacanthal potentiates the cytotoxic effects of tamoxifen in human breast cancer cells
by: Mohamed Alitheen, Noorjahan Banu, et al.
Published: (2015)

Characterisation of Plant Derived Damnacanthal and Nordamnacanthal Induced Cytotoxicity on Human HT29 Colon Adenocarcinoma Cell Line
by: Khor, Tin Oo
Published: (2001)

Characterisation of plant derived damnacanthal and nordamnacanthal induced cytotoxicity on human HT29 colon adenocarcinoma cell line /
by: Khor, Tin Oo.

Combinatorial cytotoxic effects of damnacanthal and doxorubicin against human breast cancer MCF-7 cells in vitro
by: Abdul Aziz, Muhammad Yusran, et al.
Published: (2016)

Immunomodulatory effects of damnacanthal isolated from roots of Morinda elliptica
by: Mohammed Alitheen, Noorjahan Banu, et al.
Published: (2010)

Anticancer potential of Damnacanthal and Nordamnacanthal from Morinda elliptica roots on T-lymphoblastic leukemia cells
by: Saiful Yazan, Latifah, et al.
Published: (2021)

Synthesis and cytotoxic effects of (E)-3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one in MDA-MB231 and MCF-7 breast cancer cell lines
by: Akhtar, Muhammad Nadeem, et al.
Published: (2017)

3-bromo-1-hydroxy-9,10-anthraquinone (BHAQ) inhibits growth and migration of the human breast cancer cell lines MCF-7 and MDA-MB231
by: Abu, Nadiah, et al.
Published: (2013)

Synthesis of damnacanthal, a naturally occurring 9,10-anthraquinone and its analogues, and its biological evaluation against five cancer cell lines.
by: Saha, Koushik, et al.
Published: (2013)

Cytotoxic effects of damnacanthal and damnacanthal-doxorubicin combination on human breast cancer cell line (MCF-7)
by: Abdul Aziz, Muhammad Yusran
Published: (2012)

Cytotoxic effects of damnacanthal and damnacanthal-doxorubicin combination on human breast cancer cell line (MCF-7)
by: Abdul Aziz, Muhammad Yusran
Published: (2012)

Cytotoxic effects of damnacanthal and damnacanthal-doxorubicin combination on human breast cancer cell line (MCF-7) /
by: Muhammad Yusran Abdul Aziz.
Published: (2012)

Synthesis of anthraquinone derivative (DHAQC) and its effect on induction of G2/M arrest and apoptosis in breast cancer MCF-7 cell lines
by: Yeap, Swee Keong, et al.
Published: (2015)

Effects of Damnacanthal, Nordamnacanthal, Betulinic Acid and Zerumbone Isolated from Local Medicinal Plants on Leukemia Cell Lines and Immune Cells
by: Abd Rahman, Mashitoh
Published: (2007)

Ultrastructural and morphological effects in T-Lymphoblastic leukaemia, CEM-SS Cells following treatment with Nordamnacanthal and Damnacanthal from Roots of Morinda elliptica
by: Saiful Yazan, Latifah, et al.
Published: (2021)

Ultrastructural and morphological effects in T-lymphoblastic leukemia CEM-SS cells following treatment with nordamnacanthal and damnacanthal from roots of Morinda elliptica
by: Latifah, Saiful Yazan, et al.
Published: (2022)

Effects of Damnacanthal, Nordamnacanthal, Betulinic Acid and Zerumbone Isolated from Local Medicinal Plants on Leukemia Cell Lines and Immune Cells
by: Abd. Rahman, Mashitoh
Published: (2007)

Effects of damnacanthal, nordamnacanthal, betulinic acid and zerumbone isolated from local medicinal plants on leukemia cell lines and immune cells /
by: Mashitoh Abd. Rahman.

Synergistic cytotoxicity between elephantopus scaber and tamoxifen on MCF-7-derived multicellular tumor spheroid
by: Ho, Wan Yong, et al.
Published: (2021)

Cytotoxicity and apoptosis effects of curcumin analogue (2E,6E)-2,6-Bis(2,3-Dimethoxybenzylidine) Cyclohexanone (DMCH) on human colon cancer cells HT29 and SW620 in vitro
by: Che Rahim, Nurul Fattin, et al.
Published: (2021)

Design, synthesis and cytotoxic effects of curcuminoids on HeLa, K562, MCF-7 and MDA-MB-231 cancer cell lines
by: Zamrus, Siti Noor Hajar, et al.
Published: (2018)

Design, synthesis and docking studies of Flavokawain B type chalcones and their cytotoxic effects on MCF-7 and MDA-MB-231 cell lines
by: Abu Bakar, Addila, et al.
Published: (2018)

Cytotoxic effects of damnacanthal towards human mammary carcinoma cell line (MDA-MB-231) /
by: Hisyam Abdul Hamid

Immunomodulatory effect of Rhaphidophora korthalsii on natural killer cell cytotoxicity.
by: Yeap, Swee Keong, et al.
Published: (2012)

Selective cytotoxicity of goniothalamin against hepatoblastoma HepG2 cells.
by: Al-Qubaisi, Mothanna, et al.
Published: (2011)

Damnacanthal is a potent inducer of apoptosis with anticancer activity by stimulating p53 and p21 genes in MCF-7 breast cancer cells
by: Abdul Aziz, Muhammad Yusran, et al.
Published: (2014)

(3E)-3-(4-(Dimenthylamino)Phenyl)-1-(4-Hydroxyphenyl)Prop-2-En-1-One
by: Hasan, Aurangzeb, et al.
Published: (2010)

Rhaphidophora korthalsii modulates peripheral blood natural killer cell proliferation, cytokine secretion and cytotoxicity
by: Yeap, Swee Keong, et al.
Published: (2013)

Dual regulation of cell death and cell survival upon induction of cellular stress by Isopimara-7, 15-Dien-19-Oic acid in cervical cancer, HeLa cells in vitro
by: Abu, Nadiah, et al.
Published: (2016)

Characterisation of Plant Derived Damnacanthal and Nordamnacantbal Induced Cytotoxicity on Human HT29 Colon Adenocarcinoma Cell Line
by: Khor, Tin Oo
Published: (2001)

Cytotoxic effects of commercial wheatgrass and fiber towards human acute promyelocytic leukemia cells (HL60).
by: Mohamed Alitheen, Noorjahan Banu, et al.
Published: (2011)

Subchronic toxicity, immunoregulation and anti-breast tumor effect of Nordamnacantal, an anthraquinone extracted from the stems of Morinda citrifolia L.
by: Abu, Nadiah, et al.
Published: (2018)