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The Vibrio campbellii quorum sensing signals have a different impact on virulence of the bacterium towards different crustacean hosts.

Pathogenic bacteria communicate with small signal molecules in a process called quorum sensing, and they often use different signal molecules to regulate virulence gene expression. Vibrio campbellii, one of the major pathogens of aquatic organisms, regulates virulence gene expression by a three chan...

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Główni autorzy: Julyantoro Pande, Gde Sasmita, Mohd Ikhsan, Natrah Fatin, Sorgeloos, Patrick, Bossier, Peter, Defoirdt, Tom
Format: Artykuł
Język:English
English
Wydane: Elsevier 2013
Dostęp online:http://psasir.upm.edu.my/id/eprint/29437/1/The%20Vibrio%20campbellii%20quorum%20sensing%20signals%20have%20a%20different%20impact%20on%20virulence%20of%20the%20bacterium%20towards%20different%20crustacean%20hosts.pdf
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spelling oai:psasir.upm.edu.my:29437 http://psasir.upm.edu.my/id/eprint/29437/ The Vibrio campbellii quorum sensing signals have a different impact on virulence of the bacterium towards different crustacean hosts. Julyantoro Pande, Gde Sasmita Mohd Ikhsan, Natrah Fatin Sorgeloos, Patrick Bossier, Peter Defoirdt, Tom Pathogenic bacteria communicate with small signal molecules in a process called quorum sensing, and they often use different signal molecules to regulate virulence gene expression. Vibrio campbellii, one of the major pathogens of aquatic organisms, regulates virulence gene expression by a three channel quorum sensing system. Here we show that although they use a common signal transduction cascade, the signal molecules have a different impact on the virulence of the bacterium towards different hosts, i.e. the brine shrimp Artemia franciscana and the commercially important giant freshwater prawn Macrobrachium rosenbergii. These results suggest that the use of multiple types of signal molecules to regulate virulence gene expression is one of the features that allow bacteria to infect different hosts. Our findings emphasize that it is highly important to study the efficacy of quorum sensing inhibitors as novel biocontrol agents under conditions that are as close as possible to the clinical situation. Elsevier 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29437/1/The%20Vibrio%20campbellii%20quorum%20sensing%20signals%20have%20a%20different%20impact%20on%20virulence%20of%20the%20bacterium%20towards%20different%20crustacean%20hosts.pdf Julyantoro Pande, Gde Sasmita and Mohd Ikhsan, Natrah Fatin and Sorgeloos, Patrick and Bossier, Peter and Defoirdt, Tom (2013) The Vibrio campbellii quorum sensing signals have a different impact on virulence of the bacterium towards different crustacean hosts. Veterinary Microbiology, 167 (3-4). pp. 540-545. ISSN 0378-1135; ESSN: 1873-2542 10.1016/j.vetmic.2013.08.021 English
institution UPM IR
collection UPM IR
language English
English
description Pathogenic bacteria communicate with small signal molecules in a process called quorum sensing, and they often use different signal molecules to regulate virulence gene expression. Vibrio campbellii, one of the major pathogens of aquatic organisms, regulates virulence gene expression by a three channel quorum sensing system. Here we show that although they use a common signal transduction cascade, the signal molecules have a different impact on the virulence of the bacterium towards different hosts, i.e. the brine shrimp Artemia franciscana and the commercially important giant freshwater prawn Macrobrachium rosenbergii. These results suggest that the use of multiple types of signal molecules to regulate virulence gene expression is one of the features that allow bacteria to infect different hosts. Our findings emphasize that it is highly important to study the efficacy of quorum sensing inhibitors as novel biocontrol agents under conditions that are as close as possible to the clinical situation.
format Article
author Julyantoro Pande, Gde Sasmita
Mohd Ikhsan, Natrah Fatin
Sorgeloos, Patrick
Bossier, Peter
Defoirdt, Tom
spellingShingle Julyantoro Pande, Gde Sasmita
Mohd Ikhsan, Natrah Fatin
Sorgeloos, Patrick
Bossier, Peter
Defoirdt, Tom
The Vibrio campbellii quorum sensing signals have a different impact on virulence of the bacterium towards different crustacean hosts.
author_facet Julyantoro Pande, Gde Sasmita
Mohd Ikhsan, Natrah Fatin
Sorgeloos, Patrick
Bossier, Peter
Defoirdt, Tom
author_sort Julyantoro Pande, Gde Sasmita
title The Vibrio campbellii quorum sensing signals have a different impact on virulence of the bacterium towards different crustacean hosts.
title_short The Vibrio campbellii quorum sensing signals have a different impact on virulence of the bacterium towards different crustacean hosts.
title_full The Vibrio campbellii quorum sensing signals have a different impact on virulence of the bacterium towards different crustacean hosts.
title_fullStr The Vibrio campbellii quorum sensing signals have a different impact on virulence of the bacterium towards different crustacean hosts.
title_full_unstemmed The Vibrio campbellii quorum sensing signals have a different impact on virulence of the bacterium towards different crustacean hosts.
title_sort vibrio campbellii quorum sensing signals have a different impact on virulence of the bacterium towards different crustacean hosts.
publisher Elsevier
publishDate 2013
url http://psasir.upm.edu.my/id/eprint/29437/1/The%20Vibrio%20campbellii%20quorum%20sensing%20signals%20have%20a%20different%20impact%20on%20virulence%20of%20the%20bacterium%20towards%20different%20crustacean%20hosts.pdf
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score 13.4562235

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