Beeld op de omslag

Antibody and immune memory persistence post infant hepatitis B vaccination

OBJECTIVES: This study aimed to evaluate the level of hepatitis B immunity among undergraduate students 23 years after commencement of the nationwide hepatitis B childhood immunization program in Malaysia. METHODS: A total of 402 serum samples obtained from volunteer undergraduate students were scr...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Shuaibu, Hudu Abdullahi, A. Malik, Yasmin, Mohd Taib, Niazlin, Mohammed Harmal, Nabil Saad, Adnan, Ariza, Alshrari, Ahmed Subeh D., Sekawi, Zamberi
Formaat: Artikel
Taal:English
Gepubliceerd in: Dove Medical Press 2013
Online toegang:http://psasir.upm.edu.my/id/eprint/29713/1/29713.pdf
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!
id oai:psasir.upm.edu.my:29713
record_format eprints
spelling oai:psasir.upm.edu.my:29713 http://psasir.upm.edu.my/id/eprint/29713/ Antibody and immune memory persistence post infant hepatitis B vaccination Shuaibu, Hudu Abdullahi A. Malik, Yasmin Mohd Taib, Niazlin Mohammed Harmal, Nabil Saad Adnan, Ariza Alshrari, Ahmed Subeh D. Sekawi, Zamberi OBJECTIVES: This study aimed to evaluate the level of hepatitis B immunity among undergraduate students 23 years after commencement of the nationwide hepatitis B childhood immunization program in Malaysia. METHODS: A total of 402 serum samples obtained from volunteer undergraduate students were screened for the presence of hepatitis B surface antibodies using qualitative ELISA. RESULTS: Results showed that 62.7% of volunteers had protective anti-hepatitis B surface antigens (≥10 IU/L), of whom 67.9% received three doses of the vaccine. The estimated post-vaccination immunity was found to be at least 20 years, indicating persistent immunity against hepatitis B and a significant association (P < 0.05) with duration of vaccination. Anamnestic response 1 month post-hepatitis B booster was 94.0% and highly significant (P < 0.01). Isolated antihepatitis B core antigen (anti-HBc) prevalence was found to be 5.0%, all having had a positive anamnestic response. CONCLUSION: Immunity after primary vaccination with hepatitis B recombinant vaccine persists for at least 20 years post-vaccination, with significant association with the number of vaccinations. Furthermore, the presence of anamnestic response to booster vaccine indicates long-lasting immunity despite decreasing antibody levels; therefore, the need for hepatitis B vaccine boosters may not be of significant benefit after complete infant vaccination. Dove Medical Press 2013-09-26 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29713/1/29713.pdf Shuaibu, Hudu Abdullahi and A. Malik, Yasmin and Mohd Taib, Niazlin and Mohammed Harmal, Nabil Saad and Adnan, Ariza and Alshrari, Ahmed Subeh D. and Sekawi, Zamberi (2013) Antibody and immune memory persistence post infant hepatitis B vaccination. Patient Preference and Adherence, 7. pp. 981-986. ISSN 1177-889X https://www.dovepress.com/antibody-and-immune-memory-persistence-post-infant-hepatitis-b-vaccina-peer-reviewed-article-PPA 10.2147/PPA.S49776
institution UPM IR
collection UPM IR
language English
description OBJECTIVES: This study aimed to evaluate the level of hepatitis B immunity among undergraduate students 23 years after commencement of the nationwide hepatitis B childhood immunization program in Malaysia. METHODS: A total of 402 serum samples obtained from volunteer undergraduate students were screened for the presence of hepatitis B surface antibodies using qualitative ELISA. RESULTS: Results showed that 62.7% of volunteers had protective anti-hepatitis B surface antigens (≥10 IU/L), of whom 67.9% received three doses of the vaccine. The estimated post-vaccination immunity was found to be at least 20 years, indicating persistent immunity against hepatitis B and a significant association (P < 0.05) with duration of vaccination. Anamnestic response 1 month post-hepatitis B booster was 94.0% and highly significant (P < 0.01). Isolated antihepatitis B core antigen (anti-HBc) prevalence was found to be 5.0%, all having had a positive anamnestic response. CONCLUSION: Immunity after primary vaccination with hepatitis B recombinant vaccine persists for at least 20 years post-vaccination, with significant association with the number of vaccinations. Furthermore, the presence of anamnestic response to booster vaccine indicates long-lasting immunity despite decreasing antibody levels; therefore, the need for hepatitis B vaccine boosters may not be of significant benefit after complete infant vaccination.
format Article
author Shuaibu, Hudu Abdullahi
A. Malik, Yasmin
Mohd Taib, Niazlin
Mohammed Harmal, Nabil Saad
Adnan, Ariza
Alshrari, Ahmed Subeh D.
Sekawi, Zamberi
spellingShingle Shuaibu, Hudu Abdullahi
A. Malik, Yasmin
Mohd Taib, Niazlin
Mohammed Harmal, Nabil Saad
Adnan, Ariza
Alshrari, Ahmed Subeh D.
Sekawi, Zamberi
Antibody and immune memory persistence post infant hepatitis B vaccination
author_facet Shuaibu, Hudu Abdullahi
A. Malik, Yasmin
Mohd Taib, Niazlin
Mohammed Harmal, Nabil Saad
Adnan, Ariza
Alshrari, Ahmed Subeh D.
Sekawi, Zamberi
author_sort Shuaibu, Hudu Abdullahi
title Antibody and immune memory persistence post infant hepatitis B vaccination
title_short Antibody and immune memory persistence post infant hepatitis B vaccination
title_full Antibody and immune memory persistence post infant hepatitis B vaccination
title_fullStr Antibody and immune memory persistence post infant hepatitis B vaccination
title_full_unstemmed Antibody and immune memory persistence post infant hepatitis B vaccination
title_sort antibody and immune memory persistence post infant hepatitis b vaccination
publisher Dove Medical Press
publishDate 2013
url http://psasir.upm.edu.my/id/eprint/29713/1/29713.pdf
_version_ 1782720493107806208
score 12.933938

Gelijkaardige items