Medarbejdervisning: Clinical and pathological changes in goats inoculated Corynebacterium pseudotuberculosis by intradermal, intranasal and oral routes

Clinical and pathological changes in goats inoculated Corynebacterium pseudotuberculosis by intradermal, intranasal and oral routes

This study describes lesions and clinical responses that develop in goats following experimental infection with Corynebacterium pseudotuberculosis by intradermal, intranasal and oral administration. Three groups of 5 goats each were given 1 ml inoculum containing 107 cfu/ml live Corynebacterium pse...

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Main Authors:	Mohd Nordi, Nur Adza Rina, Saad, Mohd Zamri, Abdullah, Faez Firdaus Jesse, Saharee, Abdul Aziz, Haron, Abdul Wahid, Shamsudin, Shahirudin
Format:	Article
Sprog:	English
Udgivet:	Online Journal of Veterinary Research 2013
Online adgang:	http://psasir.upm.edu.my/id/eprint/29844/1/Clinical%20and%20pathological%20changes%20in%20goats%20inoculated%20Corynebacterium%20pseudotuberculosis%20by%20intradermal.pdf
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id	oai:psasir.upm.edu.my:29844
record_format	eprints
spelling	oai:psasir.upm.edu.my:29844 http://psasir.upm.edu.my/id/eprint/29844/ Clinical and pathological changes in goats inoculated Corynebacterium pseudotuberculosis by intradermal, intranasal and oral routes Mohd Nordi, Nur Adza Rina Saad, Mohd Zamri Abdullah, Faez Firdaus Jesse Saharee, Abdul Aziz Haron, Abdul Wahid Shamsudin, Shahirudin This study describes lesions and clinical responses that develop in goats following experimental infection with Corynebacterium pseudotuberculosis by intradermal, intranasal and oral administration. Three groups of 5 goats each were given 1 ml inoculum containing 107 cfu/ml live Corynebacterium pseudotuberculosis by intradermal, intranasal and oral routes, respectively. Controls were unexposed normals. Goats were assessed for clinical signs, body temperature and blood cell count and serum biochemistry. The animals were euthanized 30 days after exposure and pre-scapular, submandibular, supra-mammary, inguinal and mesenteric lymph nodes, lung, liver and kidneys were excised for bacterial isolation and histopathology examinations. Compared with controls, goats inoculated with Corynebacterium pseudotuberculosis showed higher body temperatures at week 1 which returned to normal by week 2. Intradermal infection increased leukocytes and ALT levels and induced severe abscesses in lymph nodes. Pulmonary congestion, liver abcesses, splegnomegalia and renal congestion were found. Intranasal infection produced the most apparent severe lesions in the mesenteric lymph nodes whereas oral administration induced the most severe supra-mammary lymph nodes lesions. The results suggest that intradermal C pseudotuberculosis infection in goats may induce the most severe and widespread lesions compared with other routes of administration. Online Journal of Veterinary Research 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29844/1/Clinical%20and%20pathological%20changes%20in%20goats%20inoculated%20Corynebacterium%20pseudotuberculosis%20by%20intradermal.pdf Mohd Nordi, Nur Adza Rina and Saad, Mohd Zamri and Abdullah, Faez Firdaus Jesse and Saharee, Abdul Aziz and Haron, Abdul Wahid and Shamsudin, Shahirudin (2013) Clinical and pathological changes in goats inoculated Corynebacterium pseudotuberculosis by intradermal, intranasal and oral routes. Online Journal of Veterinary Research, 17 (2). pp. 73-83. ISSN 1328-925X http://onljvetres.com/goatstuberculosisabs2013.htm
institution	UPM IR
collection	UPM IR
language	English
description	This study describes lesions and clinical responses that develop in goats following experimental infection with Corynebacterium pseudotuberculosis by intradermal, intranasal and oral administration. Three groups of 5 goats each were given 1 ml inoculum containing 107 cfu/ml live Corynebacterium pseudotuberculosis by intradermal, intranasal and oral routes, respectively. Controls were unexposed normals. Goats were assessed for clinical signs, body temperature and blood cell count and serum biochemistry. The animals were euthanized 30 days after exposure and pre-scapular, submandibular, supra-mammary, inguinal and mesenteric lymph nodes, lung, liver and kidneys were excised for bacterial isolation and histopathology examinations. Compared with controls, goats inoculated with Corynebacterium pseudotuberculosis showed higher body temperatures at week 1 which returned to normal by week 2. Intradermal infection increased leukocytes and ALT levels and induced severe abscesses in lymph nodes. Pulmonary congestion, liver abcesses, splegnomegalia and renal congestion were found. Intranasal infection produced the most apparent severe lesions in the mesenteric lymph nodes whereas oral administration induced the most severe supra-mammary lymph nodes lesions. The results suggest that intradermal C pseudotuberculosis infection in goats may induce the most severe and widespread lesions compared with other routes of administration.
format	Article
author	Mohd Nordi, Nur Adza Rina Saad, Mohd Zamri Abdullah, Faez Firdaus Jesse Saharee, Abdul Aziz Haron, Abdul Wahid Shamsudin, Shahirudin
spellingShingle	Mohd Nordi, Nur Adza Rina Saad, Mohd Zamri Abdullah, Faez Firdaus Jesse Saharee, Abdul Aziz Haron, Abdul Wahid Shamsudin, Shahirudin Clinical and pathological changes in goats inoculated Corynebacterium pseudotuberculosis by intradermal, intranasal and oral routes
author_facet	Mohd Nordi, Nur Adza Rina Saad, Mohd Zamri Abdullah, Faez Firdaus Jesse Saharee, Abdul Aziz Haron, Abdul Wahid Shamsudin, Shahirudin
author_sort	Mohd Nordi, Nur Adza Rina
title	Clinical and pathological changes in goats inoculated Corynebacterium pseudotuberculosis by intradermal, intranasal and oral routes
title_short	Clinical and pathological changes in goats inoculated Corynebacterium pseudotuberculosis by intradermal, intranasal and oral routes
title_full	Clinical and pathological changes in goats inoculated Corynebacterium pseudotuberculosis by intradermal, intranasal and oral routes
title_fullStr	Clinical and pathological changes in goats inoculated Corynebacterium pseudotuberculosis by intradermal, intranasal and oral routes
title_full_unstemmed	Clinical and pathological changes in goats inoculated Corynebacterium pseudotuberculosis by intradermal, intranasal and oral routes
title_sort	clinical and pathological changes in goats inoculated corynebacterium pseudotuberculosis by intradermal, intranasal and oral routes
publisher	Online Journal of Veterinary Research
publishDate	2013
url	http://psasir.upm.edu.my/id/eprint/29844/1/Clinical%20and%20pathological%20changes%20in%20goats%20inoculated%20Corynebacterium%20pseudotuberculosis%20by%20intradermal.pdf
_version_	1819295265372241920
score	13.4562235

Clinical and pathological changes in goats inoculated Corynebacterium pseudotuberculosis by intradermal, intranasal and oral routes

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