Antileukemic activity of extracts and constituents of Aegle marmelos
Phytochemicals study of various parts of Aegle marmelos (leaves, stem bark and roots) have afforded eleven compounds; hopane and lupane triterpenes including zeorin (1), dustanin (2) also epilupeol (3) and lupenone (4); alkaloids aegeline (5) and skimmianine (6); coumarin derivatives; auraptene (7),...
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| Main Authors: | , , , , |
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| Format: | Article |
| Jezik: | English English |
| Izdano: |
International Congress of Chemistry and Environment
2013
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| Online dostop: | http://psasir.upm.edu.my/id/eprint/30038/1/Antileukemic%20activity%20of%20extracts%20and%20constituents%20of%20Aegle%20marmelos.pdf |
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| Izvleček: | Phytochemicals study of various parts of Aegle marmelos (leaves, stem bark and roots) have afforded eleven compounds; hopane and lupane triterpenes including zeorin (1), dustanin (2) also epilupeol (3) and lupenone (4); alkaloids aegeline (5) and skimmianine (6); coumarin derivatives; auraptene (7), epoxyauraptene (8) and marmin (9) together with β-sitosterol and stigmasterol. All crude extracts and isolated compounds were examined for their antileukemic activity against CEM-SS (human T-lymphoblastic leukemia) cancer cells using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Roots extracts exhibited significant cytotoxicity while leaves and stem bark extracts were inactive. Hopane triterpenes; zeorin (1) and dustanin (2) as well as alkaloid aegeline (5) isolated from leaves exhibited moderate to strong cytotoxicity with dustanin (2) as the most active constituent (IC50 : 5.3±0.24 μg/mL). Lupane triterpenes; epilupeol (3) and lupenone (4), in addition of coumarin derivative; marmin (9) isolated from stem bark also demonstrated moderate to strong cytotoxicity with epilupeol (3) showed significant activity (IC50 : 6.1±0.20 μg/mL). The chemical constituents isolated from roots were inactive except for epilupeol (3) and marmin (9) which have also been isolated from stem bark. |
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