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Antileukemic activity of extracts and constituents of Aegle marmelos

Phytochemicals study of various parts of Aegle marmelos (leaves, stem bark and roots) have afforded eleven compounds; hopane and lupane triterpenes including zeorin (1), dustanin (2) also epilupeol (3) and lupenone (4); alkaloids aegeline (5) and skimmianine (6); coumarin derivatives; auraptene (7),...

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Hauptverfasser: Mustahil, Noorul Adawiyah, Riyanto, Sugeng, Rahmani, Mawardi, Mohd Nor, Siti Mariam, Ali, Abdul Manaf
Format: Artikel
Sprache:English
English
Veröffentlicht: International Congress of Chemistry and Environment 2013
Online Zugang:http://psasir.upm.edu.my/id/eprint/30038/1/Antileukemic%20activity%20of%20extracts%20and%20constituents%20of%20Aegle%20marmelos.pdf
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spelling oai:psasir.upm.edu.my:30038 http://psasir.upm.edu.my/id/eprint/30038/ Antileukemic activity of extracts and constituents of Aegle marmelos Mustahil, Noorul Adawiyah Riyanto, Sugeng Rahmani, Mawardi Mohd Nor, Siti Mariam Ali, Abdul Manaf Phytochemicals study of various parts of Aegle marmelos (leaves, stem bark and roots) have afforded eleven compounds; hopane and lupane triterpenes including zeorin (1), dustanin (2) also epilupeol (3) and lupenone (4); alkaloids aegeline (5) and skimmianine (6); coumarin derivatives; auraptene (7), epoxyauraptene (8) and marmin (9) together with β-sitosterol and stigmasterol. All crude extracts and isolated compounds were examined for their antileukemic activity against CEM-SS (human T-lymphoblastic leukemia) cancer cells using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Roots extracts exhibited significant cytotoxicity while leaves and stem bark extracts were inactive. Hopane triterpenes; zeorin (1) and dustanin (2) as well as alkaloid aegeline (5) isolated from leaves exhibited moderate to strong cytotoxicity with dustanin (2) as the most active constituent (IC50 : 5.3±0.24 μg/mL). Lupane triterpenes; epilupeol (3) and lupenone (4), in addition of coumarin derivative; marmin (9) isolated from stem bark also demonstrated moderate to strong cytotoxicity with epilupeol (3) showed significant activity (IC50 : 6.1±0.20 μg/mL). The chemical constituents isolated from roots were inactive except for epilupeol (3) and marmin (9) which have also been isolated from stem bark. International Congress of Chemistry and Environment 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/30038/1/Antileukemic%20activity%20of%20extracts%20and%20constituents%20of%20Aegle%20marmelos.pdf Mustahil, Noorul Adawiyah and Riyanto, Sugeng and Rahmani, Mawardi and Mohd Nor, Siti Mariam and Ali, Abdul Manaf (2013) Antileukemic activity of extracts and constituents of Aegle marmelos. Research Journal of Chemistry and Environment, 17 (1). pp. 62-67. ISSN 0972-0626 English
institution UPM IR
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language English
English
description Phytochemicals study of various parts of Aegle marmelos (leaves, stem bark and roots) have afforded eleven compounds; hopane and lupane triterpenes including zeorin (1), dustanin (2) also epilupeol (3) and lupenone (4); alkaloids aegeline (5) and skimmianine (6); coumarin derivatives; auraptene (7), epoxyauraptene (8) and marmin (9) together with β-sitosterol and stigmasterol. All crude extracts and isolated compounds were examined for their antileukemic activity against CEM-SS (human T-lymphoblastic leukemia) cancer cells using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Roots extracts exhibited significant cytotoxicity while leaves and stem bark extracts were inactive. Hopane triterpenes; zeorin (1) and dustanin (2) as well as alkaloid aegeline (5) isolated from leaves exhibited moderate to strong cytotoxicity with dustanin (2) as the most active constituent (IC50 : 5.3±0.24 μg/mL). Lupane triterpenes; epilupeol (3) and lupenone (4), in addition of coumarin derivative; marmin (9) isolated from stem bark also demonstrated moderate to strong cytotoxicity with epilupeol (3) showed significant activity (IC50 : 6.1±0.20 μg/mL). The chemical constituents isolated from roots were inactive except for epilupeol (3) and marmin (9) which have also been isolated from stem bark.
format Article
author Mustahil, Noorul Adawiyah
Riyanto, Sugeng
Rahmani, Mawardi
Mohd Nor, Siti Mariam
Ali, Abdul Manaf
spellingShingle Mustahil, Noorul Adawiyah
Riyanto, Sugeng
Rahmani, Mawardi
Mohd Nor, Siti Mariam
Ali, Abdul Manaf
Antileukemic activity of extracts and constituents of Aegle marmelos
author_facet Mustahil, Noorul Adawiyah
Riyanto, Sugeng
Rahmani, Mawardi
Mohd Nor, Siti Mariam
Ali, Abdul Manaf
author_sort Mustahil, Noorul Adawiyah
title Antileukemic activity of extracts and constituents of Aegle marmelos
title_short Antileukemic activity of extracts and constituents of Aegle marmelos
title_full Antileukemic activity of extracts and constituents of Aegle marmelos
title_fullStr Antileukemic activity of extracts and constituents of Aegle marmelos
title_full_unstemmed Antileukemic activity of extracts and constituents of Aegle marmelos
title_sort antileukemic activity of extracts and constituents of aegle marmelos
publisher International Congress of Chemistry and Environment
publishDate 2013
url http://psasir.upm.edu.my/id/eprint/30038/1/Antileukemic%20activity%20of%20extracts%20and%20constituents%20of%20Aegle%20marmelos.pdf
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score 13.4562235

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