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Cytotoxicity of nickel zinc ferrite nanoparticles on cancer cells of epithelial origin

In this study, in vitro cytotoxicity of nickel zinc (NiZn) ferrite nanoparticles against human colon cancer HT29, breast cancer MCF7, and liver cancer HepG2 cells was examined. The morphology, homogeneity, and elemental composition of NiZn ferrite nanoparticles were investigated by scanning electron...

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Main Authors: Al-Qubaisi, Mothanna Sadiq, Abdullah, Rasedee, Flaifel, Moayad Husein, Ahmad, Sahrim, Al-Ali, Samer Hussein, Hussein, Mohd. Zobir, Eid, Eltayeb E. M., Zainal, Zulkarnain, Mohd Saeed,, Ilowefah, Muna, Fakurazi, Sharida, Mohd Isa, Norhaszalina, El Zowalaty, Mohamed Ezzat
Format: Article
Language:English
English
Published: Dove Medical Press 2013
Online Access:http://psasir.upm.edu.my/id/eprint/30267/1/Cytotoxicity%20of%20nickel%20zinc%20ferrite%20nanoparticles%20on%20cancer%20cells%20of%20epithelial%20origin.pdf
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spelling oai:psasir.upm.edu.my:30267 http://psasir.upm.edu.my/id/eprint/30267/ Cytotoxicity of nickel zinc ferrite nanoparticles on cancer cells of epithelial origin Al-Qubaisi, Mothanna Sadiq Abdullah, Rasedee Flaifel, Moayad Husein Ahmad, Sahrim Al-Ali, Samer Hussein Hussein, Mohd. Zobir Eid, Eltayeb E. M. Zainal, Zulkarnain Mohd Saeed, Ilowefah, Muna Fakurazi, Sharida Mohd Isa, Norhaszalina El Zowalaty, Mohamed Ezzat In this study, in vitro cytotoxicity of nickel zinc (NiZn) ferrite nanoparticles against human colon cancer HT29, breast cancer MCF7, and liver cancer HepG2 cells was examined. The morphology, homogeneity, and elemental composition of NiZn ferrite nanoparticles were investigated by scanning electron microscopy, transmission electron microscopy, and energy dispersive X-ray spectroscopy, respectively. The exposure of cancer cells to NiZn ferrite nano-particles (15.6-1,000 μg/mL; 72 hours) has resulted in a dose-dependent inhibition of cell growth determined by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The quantification of caspase-3 and -9 activities and DNA fragmentation to assess the cell death pathway of the treated cells showed that both were stimulated when exposed to NiZn ferrite nanoparticles. Light microscopy examination of the cells exposed to NiZn ferrite nanoparticles demonstrated significant changes in cellular morphology. The HepG2 cells were most prone to apoptosis among the three cells lines examined, as the result of treatment with NiZn nanoparticles. In conclusion, NiZn ferrite nanoparticles are suggested to have potential cytotoxicity against cancer cells. Dove Medical Press 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/30267/1/Cytotoxicity%20of%20nickel%20zinc%20ferrite%20nanoparticles%20on%20cancer%20cells%20of%20epithelial%20origin.pdf Al-Qubaisi, Mothanna Sadiq and Abdullah, Rasedee and Flaifel, Moayad Husein and Ahmad, Sahrim and Al-Ali, Samer Hussein and Hussein, Mohd. Zobir and Eid, Eltayeb E. M. and Zainal, Zulkarnain and Mohd Saeed, and Ilowefah, Muna and Fakurazi, Sharida and Mohd Isa, Norhaszalina and El Zowalaty, Mohamed Ezzat (2013) Cytotoxicity of nickel zinc ferrite nanoparticles on cancer cells of epithelial origin. International Journal of Nanomedicine, 8. pp. 2497-2508. ISSN 1176-9114; ESSN: 1178-2013 http://www.dovepress.com/international-journal-of-nanomedicine-archive5-v627 10.2147/IJN.S42367 English
institution UPM IR
collection UPM IR
language English
English
description In this study, in vitro cytotoxicity of nickel zinc (NiZn) ferrite nanoparticles against human colon cancer HT29, breast cancer MCF7, and liver cancer HepG2 cells was examined. The morphology, homogeneity, and elemental composition of NiZn ferrite nanoparticles were investigated by scanning electron microscopy, transmission electron microscopy, and energy dispersive X-ray spectroscopy, respectively. The exposure of cancer cells to NiZn ferrite nano-particles (15.6-1,000 μg/mL; 72 hours) has resulted in a dose-dependent inhibition of cell growth determined by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The quantification of caspase-3 and -9 activities and DNA fragmentation to assess the cell death pathway of the treated cells showed that both were stimulated when exposed to NiZn ferrite nanoparticles. Light microscopy examination of the cells exposed to NiZn ferrite nanoparticles demonstrated significant changes in cellular morphology. The HepG2 cells were most prone to apoptosis among the three cells lines examined, as the result of treatment with NiZn nanoparticles. In conclusion, NiZn ferrite nanoparticles are suggested to have potential cytotoxicity against cancer cells.
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author Al-Qubaisi, Mothanna Sadiq
Abdullah, Rasedee
Flaifel, Moayad Husein
Ahmad, Sahrim
Al-Ali, Samer Hussein
Hussein, Mohd. Zobir
Eid, Eltayeb E. M.
Zainal, Zulkarnain
Mohd Saeed,
Ilowefah, Muna
Fakurazi, Sharida
Mohd Isa, Norhaszalina
El Zowalaty, Mohamed Ezzat
spellingShingle Al-Qubaisi, Mothanna Sadiq
Abdullah, Rasedee
Flaifel, Moayad Husein
Ahmad, Sahrim
Al-Ali, Samer Hussein
Hussein, Mohd. Zobir
Eid, Eltayeb E. M.
Zainal, Zulkarnain
Mohd Saeed,
Ilowefah, Muna
Fakurazi, Sharida
Mohd Isa, Norhaszalina
El Zowalaty, Mohamed Ezzat
Cytotoxicity of nickel zinc ferrite nanoparticles on cancer cells of epithelial origin
author_facet Al-Qubaisi, Mothanna Sadiq
Abdullah, Rasedee
Flaifel, Moayad Husein
Ahmad, Sahrim
Al-Ali, Samer Hussein
Hussein, Mohd. Zobir
Eid, Eltayeb E. M.
Zainal, Zulkarnain
Mohd Saeed,
Ilowefah, Muna
Fakurazi, Sharida
Mohd Isa, Norhaszalina
El Zowalaty, Mohamed Ezzat
author_sort Al-Qubaisi, Mothanna Sadiq
title Cytotoxicity of nickel zinc ferrite nanoparticles on cancer cells of epithelial origin
title_short Cytotoxicity of nickel zinc ferrite nanoparticles on cancer cells of epithelial origin
title_full Cytotoxicity of nickel zinc ferrite nanoparticles on cancer cells of epithelial origin
title_fullStr Cytotoxicity of nickel zinc ferrite nanoparticles on cancer cells of epithelial origin
title_full_unstemmed Cytotoxicity of nickel zinc ferrite nanoparticles on cancer cells of epithelial origin
title_sort cytotoxicity of nickel zinc ferrite nanoparticles on cancer cells of epithelial origin
publisher Dove Medical Press
publishDate 2013
url http://psasir.upm.edu.my/id/eprint/30267/1/Cytotoxicity%20of%20nickel%20zinc%20ferrite%20nanoparticles%20on%20cancer%20cells%20of%20epithelial%20origin.pdf
_version_ 1819295306226860032
score 13.4562235

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