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Enantioselectivity investigation of short polar peptides with different positions in the Michael reaction

This work reports the effectiveness of short polar peptides as asymmetric catalysts in Michael reactions to attain good yields of enantio- and diastereoselective isomers. In a comparison, glutamic acid and histidine produced greater ee and yields when they were applied as the second amino acid in sh...

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Main Authors: Bayat, Saadi, Tejo, Bimo Ario, Abd. Malek, Emilia, Mohd Yahaya, Normi, Salleh, Abu Bakar, Abdul Rahman, Mohd Basyaruddin
Format: Article
Language:English
English
Published: Taylor & Francis 2013
Online Access:http://psasir.upm.edu.my/id/eprint/30274/1/Enantioselectivity%20investigation%20of%20short%20polar%20peptides%20with%20different%20positions%20in%20the%20Michael%20reaction.pdf
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spelling oai:psasir.upm.edu.my:30274 http://psasir.upm.edu.my/id/eprint/30274/ Enantioselectivity investigation of short polar peptides with different positions in the Michael reaction Bayat, Saadi Tejo, Bimo Ario Abd. Malek, Emilia Mohd Yahaya, Normi Salleh, Abu Bakar Abdul Rahman, Mohd Basyaruddin This work reports the effectiveness of short polar peptides as asymmetric catalysts in Michael reactions to attain good yields of enantio- and diastereoselective isomers. In a comparison, glutamic acid and histidine produced greater ee and yields when they were applied as the second amino acid in short trimeric peptides. These short polar peptides were found to be efficient organocatalysts for the asymmetric Michael addition reaction in water. Taylor & Francis 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/30274/1/Enantioselectivity%20investigation%20of%20short%20polar%20peptides%20with%20different%20positions%20in%20the%20Michael%20reaction.pdf Bayat, Saadi and Tejo, Bimo Ario and Abd. Malek, Emilia and Mohd Yahaya, Normi and Salleh, Abu Bakar and Abdul Rahman, Mohd Basyaruddin (2013) Enantioselectivity investigation of short polar peptides with different positions in the Michael reaction. Synthetic Communications, 43 (20). pp. 2725-2732. ISSN 0039-7911; ESSN: 1532-2432 10.1080/00397911.2012.736005 English
institution UPM IR
collection UPM IR
language English
English
description This work reports the effectiveness of short polar peptides as asymmetric catalysts in Michael reactions to attain good yields of enantio- and diastereoselective isomers. In a comparison, glutamic acid and histidine produced greater ee and yields when they were applied as the second amino acid in short trimeric peptides. These short polar peptides were found to be efficient organocatalysts for the asymmetric Michael addition reaction in water.
format Article
author Bayat, Saadi
Tejo, Bimo Ario
Abd. Malek, Emilia
Mohd Yahaya, Normi
Salleh, Abu Bakar
Abdul Rahman, Mohd Basyaruddin
spellingShingle Bayat, Saadi
Tejo, Bimo Ario
Abd. Malek, Emilia
Mohd Yahaya, Normi
Salleh, Abu Bakar
Abdul Rahman, Mohd Basyaruddin
Enantioselectivity investigation of short polar peptides with different positions in the Michael reaction
author_facet Bayat, Saadi
Tejo, Bimo Ario
Abd. Malek, Emilia
Mohd Yahaya, Normi
Salleh, Abu Bakar
Abdul Rahman, Mohd Basyaruddin
author_sort Bayat, Saadi
title Enantioselectivity investigation of short polar peptides with different positions in the Michael reaction
title_short Enantioselectivity investigation of short polar peptides with different positions in the Michael reaction
title_full Enantioselectivity investigation of short polar peptides with different positions in the Michael reaction
title_fullStr Enantioselectivity investigation of short polar peptides with different positions in the Michael reaction
title_full_unstemmed Enantioselectivity investigation of short polar peptides with different positions in the Michael reaction
title_sort enantioselectivity investigation of short polar peptides with different positions in the michael reaction
publisher Taylor & Francis
publishDate 2013
url http://psasir.upm.edu.my/id/eprint/30274/1/Enantioselectivity%20investigation%20of%20short%20polar%20peptides%20with%20different%20positions%20in%20the%20Michael%20reaction.pdf
_version_ 1782720551263928320
score 12.935284

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