Synthesis and antibacterial study of aaptamine derivatives
Aaptamine is a bioactive marine alkaloid containing a unique of 1H-benzo[de][1,6]naphthyridine skeleton. Aaptamine was isolated from marine sponge, Aaptos aaptos and was proposed as starting material for semi-synthetic modifications. A series of aaptamine derivatives were synthesized which consisted...
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oai:psasir.upm.edu.my:35563 http://psasir.upm.edu.my/id/eprint/35563/ Synthesis and antibacterial study of aaptamine derivatives Abdul Rashid, Fatin Nur Ain Asari, Asnuzilawati Mohamad, Habsah Mohd Nor, Siti Mariam Aaptamine is a bioactive marine alkaloid containing a unique of 1H-benzo[de][1,6]naphthyridine skeleton. Aaptamine was isolated from marine sponge, Aaptos aaptos and was proposed as starting material for semi-synthetic modifications. A series of aaptamine derivatives were synthesized which consisted of 1,4-dialkyl (2-7), 4-alkyl (8-10) and 9-O-butyryl-1,4-dialkyl (11-16) aaptamine derivatives. Each derivative was characterized by FT-IR, UV-visible, NMR and MS. The synthesized compounds were evaluated for their antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, Bacillus cereus, Staphylococcus aureus and Micrococcus sp. bacterial strains using the disc-diffusion method. Some of the derivatives showed potent antibacterial activity against certain bacterial strains. - See more at: http://www.asianjournalofchemistry.co.in/user/journal/viewarticle.aspx?ArticleID=26_21_43#sthash.Cij7XzYA.dpuf Chemic Publishing Company 2014 Article PeerReviewed Abdul Rashid, Fatin Nur Ain and Asari, Asnuzilawati and Mohamad, Habsah and Mohd Nor, Siti Mariam (2014) Synthesis and antibacterial study of aaptamine derivatives. Asian Journal of Chemistry, 26 (20). pp. 6903-6907. ISSN 0970-7077 http://www.asianjournalofchemistry.co.in/user/journal/viewarticle.aspx?ArticleID=26_21_43 10.14233/ajchem.2014.17377 |
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Aaptamine is a bioactive marine alkaloid containing a unique of 1H-benzo[de][1,6]naphthyridine skeleton. Aaptamine was isolated from marine sponge, Aaptos aaptos and was proposed as starting material for semi-synthetic modifications. A series of aaptamine derivatives were synthesized which consisted of 1,4-dialkyl (2-7), 4-alkyl (8-10) and 9-O-butyryl-1,4-dialkyl (11-16) aaptamine derivatives. Each derivative was characterized by FT-IR, UV-visible, NMR and MS. The synthesized compounds were evaluated for their antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, Bacillus cereus, Staphylococcus aureus and Micrococcus sp. bacterial strains using the disc-diffusion method. Some of the derivatives showed potent antibacterial activity against certain bacterial strains. - See more at: http://www.asianjournalofchemistry.co.in/user/journal/viewarticle.aspx?ArticleID=26_21_43#sthash.Cij7XzYA.dpuf |
| format |
Article |
| author |
Abdul Rashid, Fatin Nur Ain Asari, Asnuzilawati Mohamad, Habsah Mohd Nor, Siti Mariam |
| spellingShingle |
Abdul Rashid, Fatin Nur Ain Asari, Asnuzilawati Mohamad, Habsah Mohd Nor, Siti Mariam Synthesis and antibacterial study of aaptamine derivatives |
| author_facet |
Abdul Rashid, Fatin Nur Ain Asari, Asnuzilawati Mohamad, Habsah Mohd Nor, Siti Mariam |
| author_sort |
Abdul Rashid, Fatin Nur Ain |
| title |
Synthesis and antibacterial study of aaptamine derivatives |
| title_short |
Synthesis and antibacterial study of aaptamine derivatives |
| title_full |
Synthesis and antibacterial study of aaptamine derivatives |
| title_fullStr |
Synthesis and antibacterial study of aaptamine derivatives |
| title_full_unstemmed |
Synthesis and antibacterial study of aaptamine derivatives |
| title_sort |
synthesis and antibacterial study of aaptamine derivatives |
| publisher |
Chemic Publishing Company |
| publishDate |
2014 |
| _version_ |
1819295799071211520 |
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13.4562235 |