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Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic

This study describes the preparation, characterization, and controlled release of a streptomycin-chitosan-magnetic nanoparticle-based antibiotic in an effort to improve the treatment of bacterial infections. Specifically, chitosan-magnetic nanoparticles were synthesized by an incorporation method an...

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Main Authors: Hussein-Al-Ali, Samer Hasan, El Zowalaty, Mohamed Ezzat, Hussein, Mohd. Zobir, Ismail, Maznah, Webster, Thomas Jay
Format: Article
Published: Dove Medical Press 2014
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id oai:psasir.upm.edu.my:35585
record_format eprints
spelling oai:psasir.upm.edu.my:35585 http://psasir.upm.edu.my/id/eprint/35585/ Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic Hussein-Al-Ali, Samer Hasan El Zowalaty, Mohamed Ezzat Hussein, Mohd. Zobir Ismail, Maznah Webster, Thomas Jay This study describes the preparation, characterization, and controlled release of a streptomycin-chitosan-magnetic nanoparticle-based antibiotic in an effort to improve the treatment of bacterial infections. Specifically, chitosan-magnetic nanoparticles were synthesized by an incorporation method and were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, and vibrating sample magnetometry. Streptomycin was incorporated into the nanoparticles to form a streptomycin-coated chitosan-magnetic nanoparticle (Strep-CS-MNP) nanocomposite. The release profiles showed an initially fast release, which became slower as time progressed. The percentage of drug released after 350 minutes was around 100%, and the best fit mathematical model for drug release was the pseudo-second order model. The Strep-CS-MNP nanocomposite showed enhanced antibacterial activity against methicillin-resistant Staphylococcus aureus. This study forms a significant basis for further investigation of the Strep-CS-MNP nanocomposite in the treatment of various bacterial infections. Dove Medical Press 2014 Article PeerReviewed Hussein-Al-Ali, Samer Hasan and El Zowalaty, Mohamed Ezzat and Hussein, Mohd. Zobir and Ismail, Maznah and Webster, Thomas Jay (2014) Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic. International Journal of Nanomedicine, 9 (1). pp. 549-557. ISSN 1176-9114; ESSN: 1178-2013 https://www.dovepress.com/synthesis-characterization-controlled-release-and-antibacterial-studie-peer-reviewed-article-IJN 10.2147/IJN.S53079
institution UPM IR
collection UPM IR
description This study describes the preparation, characterization, and controlled release of a streptomycin-chitosan-magnetic nanoparticle-based antibiotic in an effort to improve the treatment of bacterial infections. Specifically, chitosan-magnetic nanoparticles were synthesized by an incorporation method and were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, and vibrating sample magnetometry. Streptomycin was incorporated into the nanoparticles to form a streptomycin-coated chitosan-magnetic nanoparticle (Strep-CS-MNP) nanocomposite. The release profiles showed an initially fast release, which became slower as time progressed. The percentage of drug released after 350 minutes was around 100%, and the best fit mathematical model for drug release was the pseudo-second order model. The Strep-CS-MNP nanocomposite showed enhanced antibacterial activity against methicillin-resistant Staphylococcus aureus. This study forms a significant basis for further investigation of the Strep-CS-MNP nanocomposite in the treatment of various bacterial infections.
format Article
author Hussein-Al-Ali, Samer Hasan
El Zowalaty, Mohamed Ezzat
Hussein, Mohd. Zobir
Ismail, Maznah
Webster, Thomas Jay
spellingShingle Hussein-Al-Ali, Samer Hasan
El Zowalaty, Mohamed Ezzat
Hussein, Mohd. Zobir
Ismail, Maznah
Webster, Thomas Jay
Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic
author_facet Hussein-Al-Ali, Samer Hasan
El Zowalaty, Mohamed Ezzat
Hussein, Mohd. Zobir
Ismail, Maznah
Webster, Thomas Jay
author_sort Hussein-Al-Ali, Samer Hasan
title Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic
title_short Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic
title_full Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic
title_fullStr Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic
title_full_unstemmed Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic
title_sort synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic
publisher Dove Medical Press
publishDate 2014
_version_ 1819295801172557824
score 13.4562235

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