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Comparative aspects of microRNA expression in canine and human cancers

MicroRNAs (miRNAs) have important roles in all biological pathways in multicellular organisms. Over 1,400 human miRNAs have been identified, and many are conserved among vertebrates and invertebrates. Regulation of miRNA is the most common mode of post-transcriptional gene regulation. The miRNAs tha...

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Main Authors: Sahabi, Kabiru, Selvarajah, Gayathri Thevi, Abdullah, Rasedee, Cheah, Yoke Kqueen, Tan, Geok Chin
Format: Article
Language:English
Published: The Korean Society of Veterinary Science 2018
Online Access:http://psasir.upm.edu.my/id/eprint/37000/1/Comparative%20aspects%20of%20microRNA%20expression%20in%20canine%20and%20human%20cancers.pdf
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spelling oai:psasir.upm.edu.my:37000 http://psasir.upm.edu.my/id/eprint/37000/ Comparative aspects of microRNA expression in canine and human cancers Sahabi, Kabiru Selvarajah, Gayathri Thevi Abdullah, Rasedee Cheah, Yoke Kqueen Tan, Geok Chin MicroRNAs (miRNAs) have important roles in all biological pathways in multicellular organisms. Over 1,400 human miRNAs have been identified, and many are conserved among vertebrates and invertebrates. Regulation of miRNA is the most common mode of post-transcriptional gene regulation. The miRNAs that are involved in the initiation and progression of cancers are termed oncomiRs and several of them have been identified in canine and human cancers. Similarly, several miRNAs have been reported to be down-regulated in cancers of the two species. In this review, current information on the expression and roles of miRNAs in oncogenesis and progression of human and canine cancers, as well the roles miRNAs have in cancer stem cell biology, are highlighted. The potential for the use of miRNAs as therapeutic targets in personalized cancer therapy in domestic dogs and their possible application in human cancer counterparts are also discussed. The Korean Society of Veterinary Science 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/37000/1/Comparative%20aspects%20of%20microRNA%20expression%20in%20canine%20and%20human%20cancers.pdf Sahabi, Kabiru and Selvarajah, Gayathri Thevi and Abdullah, Rasedee and Cheah, Yoke Kqueen and Tan, Geok Chin (2018) Comparative aspects of microRNA expression in canine and human cancers. Journal of Veterinary Science, 19 (2). pp. 162-171. ISSN 1229-845X; ESSN: 1976-555X https://vetsci.org/search.php?where=aview&id=10.4142/jvs.2018.19.2.162&code=0118JVS&vmode=AONLY# 10.4142/jvs.2018.19.2.162
institution UPM IR
collection UPM IR
language English
description MicroRNAs (miRNAs) have important roles in all biological pathways in multicellular organisms. Over 1,400 human miRNAs have been identified, and many are conserved among vertebrates and invertebrates. Regulation of miRNA is the most common mode of post-transcriptional gene regulation. The miRNAs that are involved in the initiation and progression of cancers are termed oncomiRs and several of them have been identified in canine and human cancers. Similarly, several miRNAs have been reported to be down-regulated in cancers of the two species. In this review, current information on the expression and roles of miRNAs in oncogenesis and progression of human and canine cancers, as well the roles miRNAs have in cancer stem cell biology, are highlighted. The potential for the use of miRNAs as therapeutic targets in personalized cancer therapy in domestic dogs and their possible application in human cancer counterparts are also discussed.
format Article
author Sahabi, Kabiru
Selvarajah, Gayathri Thevi
Abdullah, Rasedee
Cheah, Yoke Kqueen
Tan, Geok Chin
spellingShingle Sahabi, Kabiru
Selvarajah, Gayathri Thevi
Abdullah, Rasedee
Cheah, Yoke Kqueen
Tan, Geok Chin
Comparative aspects of microRNA expression in canine and human cancers
author_facet Sahabi, Kabiru
Selvarajah, Gayathri Thevi
Abdullah, Rasedee
Cheah, Yoke Kqueen
Tan, Geok Chin
author_sort Sahabi, Kabiru
title Comparative aspects of microRNA expression in canine and human cancers
title_short Comparative aspects of microRNA expression in canine and human cancers
title_full Comparative aspects of microRNA expression in canine and human cancers
title_fullStr Comparative aspects of microRNA expression in canine and human cancers
title_full_unstemmed Comparative aspects of microRNA expression in canine and human cancers
title_sort comparative aspects of microrna expression in canine and human cancers
publisher The Korean Society of Veterinary Science
publishDate 2018
url http://psasir.upm.edu.my/id/eprint/37000/1/Comparative%20aspects%20of%20microRNA%20expression%20in%20canine%20and%20human%20cancers.pdf
_version_ 1782721197715226624
score 12.935284

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