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Development of a highly biocompatible antituberculosis nanodelivery formulation based on para-aminosalicylic acid—zinc layered hydroxide nanocomposites

Tuberculosis is a lethal epidemic, difficult to control disease, claiming thousands of lives every year. We have developed a nanodelivery formulation based on para-aminosalicylic acid (PAS) and zinc layered hydroxide using zinc nitrate salt as a precursor. The developed formulation has a fourfold hi...

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Huvudupphovsmän: Saifullah, Bullo, Arulselvan, Palanisamy, El Zowalaty, Mohamed Ezzat, Fakurazi, Sharida, Webster, Thomas J., Geilich, Benjamin, Hussein, Mohd Zobir
Materialtyp: Artikel
Språk:English
Publicerad: Hindawi Publishing Corporation 2014
Länkar:http://psasir.upm.edu.my/id/eprint/37055/1/Development%20of%20a%20highly%20biocompatible%20antituberculosis%20nanodelivery%20formulation%20based%20on%20para.pdf
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spelling oai:psasir.upm.edu.my:37055 http://psasir.upm.edu.my/id/eprint/37055/ Development of a highly biocompatible antituberculosis nanodelivery formulation based on para-aminosalicylic acid—zinc layered hydroxide nanocomposites Saifullah, Bullo Arulselvan, Palanisamy El Zowalaty, Mohamed Ezzat Fakurazi, Sharida Webster, Thomas J. Geilich, Benjamin Hussein, Mohd Zobir Tuberculosis is a lethal epidemic, difficult to control disease, claiming thousands of lives every year. We have developed a nanodelivery formulation based on para-aminosalicylic acid (PAS) and zinc layered hydroxide using zinc nitrate salt as a precursor. The developed formulation has a fourfold higher efficacy of PAS against mycobacterium tuberculosis with a minimum inhibitory concentration (MIC) found to be at 1.40 μg/mL compared to the free drug PAS with a MIC of 5.0 μg/mL. The newly developed formulation was also found active against Gram-positive bacteria, Gram-negative bacteria, and Candida albicans. The formulation was also found to be biocompatible with human normal lung cells MRC-5 and mouse fibroblast cells-3T3. The in vitro release of PAS from the formulation was found to be sustained in a human body simulated phosphate buffer saline (PBS) solution at pH values of 7.4 and 4.8. Most importantly the nanocomposite prepared using zinc nitrate salt was advantageous in terms of yield and free from toxic zinc oxide contamination and had higher biocompatibility compared to one prepared using a zinc oxide precursor. In summary, these promising in vitro results are highly encouraging for the continued investigation of para-aminosalicylic acid and zinc layered hydroxide nanocomposites in vivo and eventual preclinical studies. Hindawi Publishing Corporation 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/37055/1/Development%20of%20a%20highly%20biocompatible%20antituberculosis%20nanodelivery%20formulation%20based%20on%20para.pdf Saifullah, Bullo and Arulselvan, Palanisamy and El Zowalaty, Mohamed Ezzat and Fakurazi, Sharida and Webster, Thomas J. and Geilich, Benjamin and Hussein, Mohd Zobir (2014) Development of a highly biocompatible antituberculosis nanodelivery formulation based on para-aminosalicylic acid—zinc layered hydroxide nanocomposites. The Scientific World Journal, 2014. art. no. 401460. pp. 1-12. ISSN 2356-6140; ESSN: 1537-744X http://www.hindawi.com/journals/tswj/2014/401460/abs/ 10.1155/2014/401460
institution UPM IR
collection UPM IR
language English
description Tuberculosis is a lethal epidemic, difficult to control disease, claiming thousands of lives every year. We have developed a nanodelivery formulation based on para-aminosalicylic acid (PAS) and zinc layered hydroxide using zinc nitrate salt as a precursor. The developed formulation has a fourfold higher efficacy of PAS against mycobacterium tuberculosis with a minimum inhibitory concentration (MIC) found to be at 1.40 μg/mL compared to the free drug PAS with a MIC of 5.0 μg/mL. The newly developed formulation was also found active against Gram-positive bacteria, Gram-negative bacteria, and Candida albicans. The formulation was also found to be biocompatible with human normal lung cells MRC-5 and mouse fibroblast cells-3T3. The in vitro release of PAS from the formulation was found to be sustained in a human body simulated phosphate buffer saline (PBS) solution at pH values of 7.4 and 4.8. Most importantly the nanocomposite prepared using zinc nitrate salt was advantageous in terms of yield and free from toxic zinc oxide contamination and had higher biocompatibility compared to one prepared using a zinc oxide precursor. In summary, these promising in vitro results are highly encouraging for the continued investigation of para-aminosalicylic acid and zinc layered hydroxide nanocomposites in vivo and eventual preclinical studies.
format Article
author Saifullah, Bullo
Arulselvan, Palanisamy
El Zowalaty, Mohamed Ezzat
Fakurazi, Sharida
Webster, Thomas J.
Geilich, Benjamin
Hussein, Mohd Zobir
spellingShingle Saifullah, Bullo
Arulselvan, Palanisamy
El Zowalaty, Mohamed Ezzat
Fakurazi, Sharida
Webster, Thomas J.
Geilich, Benjamin
Hussein, Mohd Zobir
Development of a highly biocompatible antituberculosis nanodelivery formulation based on para-aminosalicylic acid—zinc layered hydroxide nanocomposites
author_facet Saifullah, Bullo
Arulselvan, Palanisamy
El Zowalaty, Mohamed Ezzat
Fakurazi, Sharida
Webster, Thomas J.
Geilich, Benjamin
Hussein, Mohd Zobir
author_sort Saifullah, Bullo
title Development of a highly biocompatible antituberculosis nanodelivery formulation based on para-aminosalicylic acid—zinc layered hydroxide nanocomposites
title_short Development of a highly biocompatible antituberculosis nanodelivery formulation based on para-aminosalicylic acid—zinc layered hydroxide nanocomposites
title_full Development of a highly biocompatible antituberculosis nanodelivery formulation based on para-aminosalicylic acid—zinc layered hydroxide nanocomposites
title_fullStr Development of a highly biocompatible antituberculosis nanodelivery formulation based on para-aminosalicylic acid—zinc layered hydroxide nanocomposites
title_full_unstemmed Development of a highly biocompatible antituberculosis nanodelivery formulation based on para-aminosalicylic acid—zinc layered hydroxide nanocomposites
title_sort development of a highly biocompatible antituberculosis nanodelivery formulation based on para-aminosalicylic acid—zinc layered hydroxide nanocomposites
publisher Hindawi Publishing Corporation
publishDate 2014
url http://psasir.upm.edu.my/id/eprint/37055/1/Development%20of%20a%20highly%20biocompatible%20antituberculosis%20nanodelivery%20formulation%20based%20on%20para.pdf
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score 13.4562235

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