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Differentiation of rat full term amniotic fluid stem cells into dopaminergic neurons phenotype via adherent and non-adherent neural induction protocols

Recent studies have demonstrated the ability of midterm human amniotic fluid cells to generate dopaminergic (DA) neurons where none using amniotic fluid cells from full term pregnancies has been published. We have established rat AFS cell lines from full term pregnancies, where characteristics of...

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Główni autorzy: Hamzah, Siti Nurusaadah, Vidyadaran, Sharmili, Nordin, Norshariza
Format: Artykuł
Wydane: Tissue Engineering and Regenerative Medicine Society of Malaysia 2014
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spelling oai:psasir.upm.edu.my:37108 http://psasir.upm.edu.my/id/eprint/37108/ Differentiation of rat full term amniotic fluid stem cells into dopaminergic neurons phenotype via adherent and non-adherent neural induction protocols Hamzah, Siti Nurusaadah Vidyadaran, Sharmili Nordin, Norshariza Recent studies have demonstrated the ability of midterm human amniotic fluid cells to generate dopaminergic (DA) neurons where none using amniotic fluid cells from full term pregnancies has been published. We have established rat AFS cell lines from full term pregnancies, where characteristics of highly potent cells were observed with their ability to differentiate into derivatives representing the three primary germ layers including neural cells. Here we aimed to explore the differentiation potential of our newly established rat full term AFS cells to differentiate into DA neurons phenotype in vitro. Neural-like cells expressing mature and DA neurons phenotype were successfully derived using two established protocols of adherent and non-adherent neural induction assays. These findings have provided us an insight into the use of full term AFS cells as a valuable tool in cell replacement therapy for neurodegenerative diseases such as Parkinson’s disease (PD) Tissue Engineering and Regenerative Medicine Society of Malaysia 2014 Article PeerReviewed Hamzah, Siti Nurusaadah and Vidyadaran, Sharmili and Nordin, Norshariza (2014) Differentiation of rat full term amniotic fluid stem cells into dopaminergic neurons phenotype via adherent and non-adherent neural induction protocols. Regenerative Research, 3 (2). pp. 140-141. ISSN 2232-0822 http://regres.tesma.org.my/index-8.html
institution UPM IR
collection UPM IR
description Recent studies have demonstrated the ability of midterm human amniotic fluid cells to generate dopaminergic (DA) neurons where none using amniotic fluid cells from full term pregnancies has been published. We have established rat AFS cell lines from full term pregnancies, where characteristics of highly potent cells were observed with their ability to differentiate into derivatives representing the three primary germ layers including neural cells. Here we aimed to explore the differentiation potential of our newly established rat full term AFS cells to differentiate into DA neurons phenotype in vitro. Neural-like cells expressing mature and DA neurons phenotype were successfully derived using two established protocols of adherent and non-adherent neural induction assays. These findings have provided us an insight into the use of full term AFS cells as a valuable tool in cell replacement therapy for neurodegenerative diseases such as Parkinson’s disease (PD)
format Article
author Hamzah, Siti Nurusaadah
Vidyadaran, Sharmili
Nordin, Norshariza
spellingShingle Hamzah, Siti Nurusaadah
Vidyadaran, Sharmili
Nordin, Norshariza
Differentiation of rat full term amniotic fluid stem cells into dopaminergic neurons phenotype via adherent and non-adherent neural induction protocols
author_facet Hamzah, Siti Nurusaadah
Vidyadaran, Sharmili
Nordin, Norshariza
author_sort Hamzah, Siti Nurusaadah
title Differentiation of rat full term amniotic fluid stem cells into dopaminergic neurons phenotype via adherent and non-adherent neural induction protocols
title_short Differentiation of rat full term amniotic fluid stem cells into dopaminergic neurons phenotype via adherent and non-adherent neural induction protocols
title_full Differentiation of rat full term amniotic fluid stem cells into dopaminergic neurons phenotype via adherent and non-adherent neural induction protocols
title_fullStr Differentiation of rat full term amniotic fluid stem cells into dopaminergic neurons phenotype via adherent and non-adherent neural induction protocols
title_full_unstemmed Differentiation of rat full term amniotic fluid stem cells into dopaminergic neurons phenotype via adherent and non-adherent neural induction protocols
title_sort differentiation of rat full term amniotic fluid stem cells into dopaminergic neurons phenotype via adherent and non-adherent neural induction protocols
publisher Tissue Engineering and Regenerative Medicine Society of Malaysia
publishDate 2014
_version_ 1819295948438765568
score 13.4562235

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