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Improved functional recovery of osteoarthritic knee joint after treatment with chondrogenically induced multipotent cells

The aim of this study was to quantify the functional improvements of osteoarthritic (OA) knee joints after treatment with chondrogenically induced pluripotent stem cells. OA was induced in the right knee joints by the resection of the anterior cruciate ligament and medial meniscus. Nine sheep were d...

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Main Authors: Cletus, Ude Chinedu, Sulaiman, Shamsul, Ng, Min Hwei, Chen, Cheng Hui, Htwe, Ohnmar, Amaramalar, Naicker Sylva, Hassan, Shariful, Djorjevic, Ivan, Mohammad Yahya, Norhamdan, Saim, Aminuddin, Idrus, Ruszymah
Format: Article
Language:English
Published: Tissue Engineering and Regenerative Medicine Society of Malaysia 2014
Online Access:http://psasir.upm.edu.my/id/eprint/37975/1/Improved%20functional%20recovery%20of%20osteoarthritic%20knee%20joint%20after%20treatment%20with%20chondrogenically%20induced%20multipotent%20cells.pdf
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spelling oai:psasir.upm.edu.my:37975 http://psasir.upm.edu.my/id/eprint/37975/ Improved functional recovery of osteoarthritic knee joint after treatment with chondrogenically induced multipotent cells Cletus, Ude Chinedu Sulaiman, Shamsul Ng, Min Hwei Chen, Cheng Hui Htwe, Ohnmar Amaramalar, Naicker Sylva Hassan, Shariful Djorjevic, Ivan Mohammad Yahya, Norhamdan Saim, Aminuddin Idrus, Ruszymah The aim of this study was to quantify the functional improvements of osteoarthritic (OA) knee joints after treatment with chondrogenically induced pluripotent stem cells. OA was induced in the right knee joints by the resection of the anterior cruciate ligament and medial meniscus. Nine sheep were divided equally into 3 groups. Two treatment groups received either autologous chondrogenically induced adipose-derived stem cells (ADSCs) or bone marrow stem cells (BMSCs), while the control group received basal medium. Electromyography evaluations (EMGs) were conducted at week 0 (pre-OA), 8 (post-OA) and 24 (post-treatment), and compared to ascertain recovery in joint function. Multifocal subchondral lesions were developed after OA inductions and the treatment groups demonstrated the presence of regenerated neocartilages, evidenced by the presence of PKH26 tracking dye. Post-treatment EMGs showed that the controls retained significant reductions in amplitude compared to the pre-OA values, whereas ADSCs and BMSCs samples had no further significant reductions in amplitude post treatments (p<0.05). ADSCs and BMSCs treated knee joints had structural regeneration of cartilage; confirmed by PKH26 dye. The EMG analysis provided evidence of functional recovery associated to the structural regenerations. Tissue Engineering and Regenerative Medicine Society of Malaysia 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/37975/1/Improved%20functional%20recovery%20of%20osteoarthritic%20knee%20joint%20after%20treatment%20with%20chondrogenically%20induced%20multipotent%20cells.pdf Cletus, Ude Chinedu and Sulaiman, Shamsul and Ng, Min Hwei and Chen, Cheng Hui and Htwe, Ohnmar and Amaramalar, Naicker Sylva and Hassan, Shariful and Djorjevic, Ivan and Mohammad Yahya, Norhamdan and Saim, Aminuddin and Idrus, Ruszymah (2014) Improved functional recovery of osteoarthritic knee joint after treatment with chondrogenically induced multipotent cells. Regenerative Research, 3 (2). pp. 50-52. ISSN 2232-0822 http://regres.tesma.org.my/past-issues.html
institution UPM IR
collection UPM IR
language English
description The aim of this study was to quantify the functional improvements of osteoarthritic (OA) knee joints after treatment with chondrogenically induced pluripotent stem cells. OA was induced in the right knee joints by the resection of the anterior cruciate ligament and medial meniscus. Nine sheep were divided equally into 3 groups. Two treatment groups received either autologous chondrogenically induced adipose-derived stem cells (ADSCs) or bone marrow stem cells (BMSCs), while the control group received basal medium. Electromyography evaluations (EMGs) were conducted at week 0 (pre-OA), 8 (post-OA) and 24 (post-treatment), and compared to ascertain recovery in joint function. Multifocal subchondral lesions were developed after OA inductions and the treatment groups demonstrated the presence of regenerated neocartilages, evidenced by the presence of PKH26 tracking dye. Post-treatment EMGs showed that the controls retained significant reductions in amplitude compared to the pre-OA values, whereas ADSCs and BMSCs samples had no further significant reductions in amplitude post treatments (p<0.05). ADSCs and BMSCs treated knee joints had structural regeneration of cartilage; confirmed by PKH26 dye. The EMG analysis provided evidence of functional recovery associated to the structural regenerations.
format Article
author Cletus, Ude Chinedu
Sulaiman, Shamsul
Ng, Min Hwei
Chen, Cheng Hui
Htwe, Ohnmar
Amaramalar, Naicker Sylva
Hassan, Shariful
Djorjevic, Ivan
Mohammad Yahya, Norhamdan
Saim, Aminuddin
Idrus, Ruszymah
spellingShingle Cletus, Ude Chinedu
Sulaiman, Shamsul
Ng, Min Hwei
Chen, Cheng Hui
Htwe, Ohnmar
Amaramalar, Naicker Sylva
Hassan, Shariful
Djorjevic, Ivan
Mohammad Yahya, Norhamdan
Saim, Aminuddin
Idrus, Ruszymah
Improved functional recovery of osteoarthritic knee joint after treatment with chondrogenically induced multipotent cells
author_facet Cletus, Ude Chinedu
Sulaiman, Shamsul
Ng, Min Hwei
Chen, Cheng Hui
Htwe, Ohnmar
Amaramalar, Naicker Sylva
Hassan, Shariful
Djorjevic, Ivan
Mohammad Yahya, Norhamdan
Saim, Aminuddin
Idrus, Ruszymah
author_sort Cletus, Ude Chinedu
title Improved functional recovery of osteoarthritic knee joint after treatment with chondrogenically induced multipotent cells
title_short Improved functional recovery of osteoarthritic knee joint after treatment with chondrogenically induced multipotent cells
title_full Improved functional recovery of osteoarthritic knee joint after treatment with chondrogenically induced multipotent cells
title_fullStr Improved functional recovery of osteoarthritic knee joint after treatment with chondrogenically induced multipotent cells
title_full_unstemmed Improved functional recovery of osteoarthritic knee joint after treatment with chondrogenically induced multipotent cells
title_sort improved functional recovery of osteoarthritic knee joint after treatment with chondrogenically induced multipotent cells
publisher Tissue Engineering and Regenerative Medicine Society of Malaysia
publishDate 2014
url http://psasir.upm.edu.my/id/eprint/37975/1/Improved%20functional%20recovery%20of%20osteoarthritic%20knee%20joint%20after%20treatment%20with%20chondrogenically%20induced%20multipotent%20cells.pdf
_version_ 1782721333672542208
score 12.935284

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