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Association analysis of 14 candidate gene polymorphism with depression and stress among gestational diabetes mellitus

The association of candidate genes and psychological symptoms of depression, anxiety, and stress among women with gestational diabetes mellitus (GDM) in Malaysia was determined in this study, followed by the determination of their odds of getting psychological symptoms, adjusted for socio-demographi...

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Main Authors: Lee, Kai Wei, Ching, Siew Mooi, Ramachandran, Vasudevan, Tusimin, Maiza, Mohd Nordin, Noraihan, Chong, Seng Choi, Hoo, Fan Kee
Format: Article
Language:English
Published: MDPI 2019
Online Access:http://psasir.upm.edu.my/id/eprint/38214/1/38214.pdf
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spelling oai:psasir.upm.edu.my:38214 http://psasir.upm.edu.my/id/eprint/38214/ Association analysis of 14 candidate gene polymorphism with depression and stress among gestational diabetes mellitus Lee, Kai Wei Ching, Siew Mooi Ramachandran, Vasudevan Tusimin, Maiza Mohd Nordin, Noraihan Chong, Seng Choi Hoo, Fan Kee The association of candidate genes and psychological symptoms of depression, anxiety, and stress among women with gestational diabetes mellitus (GDM) in Malaysia was determined in this study, followed by the determination of their odds of getting psychological symptoms, adjusted for socio-demographical background, maternal, and clinical characteristics. Single nucleotide polymorphisms (SNPs) recorded a significant association between SNP of EPHX2 (rs17466684) and depression symptoms (AOR = 7.854, 95% CI = 1.330–46.360) and stress symptoms (AOR = 7.664, 95% CI = 1.579–37.197). Associations were also observed between stress symptoms and SNP of OXTR (rs53576) and (AOR = 2.981, 95% CI = 1.058–8.402) and SNP of NRG1 (rs2919375) (AOR = 9.894, 95% CI = 1.159–84.427). The SNP of EPHX2 (rs17466684) gene polymorphism is associated with depression symptoms among Malaysian women with GDM. SNP of EPHX2 (rs17466684), OXTR (rs53576) and NRG1 (rs2919375) are also associated with stress symptoms. MDPI 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/38214/1/38214.pdf Lee, Kai Wei and Ching, Siew Mooi and Ramachandran, Vasudevan and Tusimin, Maiza and Mohd Nordin, Noraihan and Chong, Seng Choi and Hoo, Fan Kee (2019) Association analysis of 14 candidate gene polymorphism with depression and stress among gestational diabetes mellitus. Genes, 10 (12). art. no. 988. pp. 1-20. ISSN 2073-4425 https://www.mdpi.com/2073-4425/10/12/988 10.3390/genes10120988
institution UPM IR
collection UPM IR
language English
description The association of candidate genes and psychological symptoms of depression, anxiety, and stress among women with gestational diabetes mellitus (GDM) in Malaysia was determined in this study, followed by the determination of their odds of getting psychological symptoms, adjusted for socio-demographical background, maternal, and clinical characteristics. Single nucleotide polymorphisms (SNPs) recorded a significant association between SNP of EPHX2 (rs17466684) and depression symptoms (AOR = 7.854, 95% CI = 1.330–46.360) and stress symptoms (AOR = 7.664, 95% CI = 1.579–37.197). Associations were also observed between stress symptoms and SNP of OXTR (rs53576) and (AOR = 2.981, 95% CI = 1.058–8.402) and SNP of NRG1 (rs2919375) (AOR = 9.894, 95% CI = 1.159–84.427). The SNP of EPHX2 (rs17466684) gene polymorphism is associated with depression symptoms among Malaysian women with GDM. SNP of EPHX2 (rs17466684), OXTR (rs53576) and NRG1 (rs2919375) are also associated with stress symptoms.
format Article
author Lee, Kai Wei
Ching, Siew Mooi
Ramachandran, Vasudevan
Tusimin, Maiza
Mohd Nordin, Noraihan
Chong, Seng Choi
Hoo, Fan Kee
spellingShingle Lee, Kai Wei
Ching, Siew Mooi
Ramachandran, Vasudevan
Tusimin, Maiza
Mohd Nordin, Noraihan
Chong, Seng Choi
Hoo, Fan Kee
Association analysis of 14 candidate gene polymorphism with depression and stress among gestational diabetes mellitus
author_facet Lee, Kai Wei
Ching, Siew Mooi
Ramachandran, Vasudevan
Tusimin, Maiza
Mohd Nordin, Noraihan
Chong, Seng Choi
Hoo, Fan Kee
author_sort Lee, Kai Wei
title Association analysis of 14 candidate gene polymorphism with depression and stress among gestational diabetes mellitus
title_short Association analysis of 14 candidate gene polymorphism with depression and stress among gestational diabetes mellitus
title_full Association analysis of 14 candidate gene polymorphism with depression and stress among gestational diabetes mellitus
title_fullStr Association analysis of 14 candidate gene polymorphism with depression and stress among gestational diabetes mellitus
title_full_unstemmed Association analysis of 14 candidate gene polymorphism with depression and stress among gestational diabetes mellitus
title_sort association analysis of 14 candidate gene polymorphism with depression and stress among gestational diabetes mellitus
publisher MDPI
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/38214/1/38214.pdf
_version_ 1782721370456588288
score 12.935284

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