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Nasal carriage of Staphylococcus aureus among healthy adults

Background and Purpose: Data on the carriage rate and antibiotic sensitivity pattern of Staphylococcus aureus strains prevalent in the community are not available for many developing countries including Malaysia. To estimate the extent of community S. aureus transmission, in particular methicillin-r...

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Main Authors: Chong, Seng Choi, Chow, Suet Yin, Abu Bakar, Afra, Sakewi, Zamberi, Naing, Nyi Nyi, Jamal, Farida, Othman, Norlijah
Format: Article
Language:English
Published: Elsevier 2006
Online Access:http://psasir.upm.edu.my/id/eprint/40054/1/Nasal%20carriage%20of%20Staphylococcus%20aureus%20among%20healthy%20adults.pdf
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spelling oai:psasir.upm.edu.my:40054 http://psasir.upm.edu.my/id/eprint/40054/ Nasal carriage of Staphylococcus aureus among healthy adults Chong, Seng Choi Chow, Suet Yin Abu Bakar, Afra Sakewi, Zamberi Naing, Nyi Nyi Jamal, Farida Othman, Norlijah Background and Purpose: Data on the carriage rate and antibiotic sensitivity pattern of Staphylococcus aureus strains prevalent in the community are not available for many developing countries including Malaysia. To estimate the extent of community S. aureus transmission, in particular methicillin-resistant S. aureus (MRSA), the prevalence of S. aureus nasal colonization in a population of healthy adults was determined. Factors associated with S. aureus nasal carriage and antibiotic sensitivity patterns of the isolates were also analyzed. Methods: A cross-sectional study involving 346 adults was conducted. Nasal swabs were examined for the presence of S. aureus. Epidemiological information concerning risk factors for nasal carriage was also obtained. Antibiotic susceptibility testing was performed using the disk diffusion method according to the National Committee for Clinical Laboratory Standards guidelines. MRSA strains isolated were further subjected to pulse-field gel electrophoresis analysis. Results: The prevalence of S. aureus nasal carriage was 23.4%. The findings also revealed that ex-smokers (95% confidence interval [CI] 1.08-6.32, p=0.033) and oral contraceptive users (95% CI 1.12-21.67, p=0.035) were more likely to harbor S. aureus. One person was colonized with MRSA, which was different from the hospital strain. Conclusion: MRSA nasal colonization was found to be low outside of the health care environment. Smokers and oral contraceptive users have high nasal carrier rates. Elsevier 2006-12 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/40054/1/Nasal%20carriage%20of%20Staphylococcus%20aureus%20among%20healthy%20adults.pdf Chong, Seng Choi and Chow, Suet Yin and Abu Bakar, Afra and Sakewi, Zamberi and Naing, Nyi Nyi and Jamal, Farida and Othman, Norlijah (2006) Nasal carriage of Staphylococcus aureus among healthy adults. Journal of Microbiology, Immunology and Infection, 39 (6). pp. 458-464. ISSN 1684-1182; ESSN: 1995-9133 http://www.ejmii.com/issue_abstract.php?code=PDT4b0e741317ad8
institution UPM IR
collection UPM IR
language English
description Background and Purpose: Data on the carriage rate and antibiotic sensitivity pattern of Staphylococcus aureus strains prevalent in the community are not available for many developing countries including Malaysia. To estimate the extent of community S. aureus transmission, in particular methicillin-resistant S. aureus (MRSA), the prevalence of S. aureus nasal colonization in a population of healthy adults was determined. Factors associated with S. aureus nasal carriage and antibiotic sensitivity patterns of the isolates were also analyzed. Methods: A cross-sectional study involving 346 adults was conducted. Nasal swabs were examined for the presence of S. aureus. Epidemiological information concerning risk factors for nasal carriage was also obtained. Antibiotic susceptibility testing was performed using the disk diffusion method according to the National Committee for Clinical Laboratory Standards guidelines. MRSA strains isolated were further subjected to pulse-field gel electrophoresis analysis. Results: The prevalence of S. aureus nasal carriage was 23.4%. The findings also revealed that ex-smokers (95% confidence interval [CI] 1.08-6.32, p=0.033) and oral contraceptive users (95% CI 1.12-21.67, p=0.035) were more likely to harbor S. aureus. One person was colonized with MRSA, which was different from the hospital strain. Conclusion: MRSA nasal colonization was found to be low outside of the health care environment. Smokers and oral contraceptive users have high nasal carrier rates.
format Article
author Chong, Seng Choi
Chow, Suet Yin
Abu Bakar, Afra
Sakewi, Zamberi
Naing, Nyi Nyi
Jamal, Farida
Othman, Norlijah
spellingShingle Chong, Seng Choi
Chow, Suet Yin
Abu Bakar, Afra
Sakewi, Zamberi
Naing, Nyi Nyi
Jamal, Farida
Othman, Norlijah
Nasal carriage of Staphylococcus aureus among healthy adults
author_facet Chong, Seng Choi
Chow, Suet Yin
Abu Bakar, Afra
Sakewi, Zamberi
Naing, Nyi Nyi
Jamal, Farida
Othman, Norlijah
author_sort Chong, Seng Choi
title Nasal carriage of Staphylococcus aureus among healthy adults
title_short Nasal carriage of Staphylococcus aureus among healthy adults
title_full Nasal carriage of Staphylococcus aureus among healthy adults
title_fullStr Nasal carriage of Staphylococcus aureus among healthy adults
title_full_unstemmed Nasal carriage of Staphylococcus aureus among healthy adults
title_sort nasal carriage of staphylococcus aureus among healthy adults
publisher Elsevier
publishDate 2006
url http://psasir.upm.edu.my/id/eprint/40054/1/Nasal%20carriage%20of%20Staphylococcus%20aureus%20among%20healthy%20adults.pdf
_version_ 1782721586519867392
score 12.933938

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